Araştırma Makalesi
BibTex RIS Kaynak Göster

Structural, Spectral, Antibacterial and Anticancer Investigations of Synthesized Isoxazole Derivatives

Yıl 2023, Cilt: 7 Sayı: 3, 30 - 41, 03.09.2023

Elif Güney Koray Sayin

https://doi.org/10.33435/tcandtc.1270359
Bu makale için tarihinde bir düzeltme yayımlandı. https://dergipark.org.tr/tr/pub/tcandtc/issue/78795/1417331

Öz

Cancer is one of the most important diseases threatening human health today, and gastric cancer is among the top five in terms of mortality rate. Synthesized eight isoxazole derivatives were investigated in this study as computationally. Structural properties of them were examined in detail and chemical/electronic properties of these compounds are investigated using contour plot of HOMO/LUMO and molecular electrostatic potential (MEP) map. Anticancer properties of these compounds are investigated using molecular docking calculations against H. Pylori and VEGFR2. Additionally, the pharmacokinetics and pharmacology properties are investigated using ADME and p450 analyses Finally, it was found that compound 5a is the best inhibitor candidate.

Anahtar Kelimeler

Isoxazole Gastric Cancer H. Pylori VEGFR2 ADME

Kaynakça

  • [1] alsljdlkajskld

Yıl 2023, Cilt: 7 Sayı: 3, 30 - 41, 03.09.2023

Elif Güney Koray Sayin

https://doi.org/10.33435/tcandtc.1270359
Bu makale için tarihinde bir düzeltme yayımlandı. https://dergipark.org.tr/tr/pub/tcandtc/issue/78795/1417331

Öz

Kaynakça

  • [1] alsljdlkajskld
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Kimya Mühendisliği
Bölüm Research Article
Yazarlar

Elif Güney 0009-0006-1280-2512

Koray Sayin 0000-0001-6648-5010

Erken Görünüm Tarihi 26 Mayıs 2023
Yayımlanma Tarihi 3 Eylül 2023
Gönderilme Tarihi 24 Mart 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 7 Sayı: 3

Kaynak Göster

APA Güney, E., & Sayin, K. (2023). Structural, Spectral, Antibacterial and Anticancer Investigations of Synthesized Isoxazole Derivatives. Turkish Computational and Theoretical Chemistry, 7(3), 30-41. https://doi.org/10.33435/tcandtc.1270359
AMA Güney E, Sayin K. Structural, Spectral, Antibacterial and Anticancer Investigations of Synthesized Isoxazole Derivatives. Turkish Comp Theo Chem (TC&TC). Eylül 2023;7(3):30-41. doi:10.33435/tcandtc.1270359
Chicago Güney, Elif, ve Koray Sayin. “Structural, Spectral, Antibacterial and Anticancer Investigations of Synthesized Isoxazole Derivatives”. Turkish Computational and Theoretical Chemistry 7, sy. 3 (Eylül 2023): 30-41. https://doi.org/10.33435/tcandtc.1270359.
EndNote Güney E, Sayin K (01 Eylül 2023) Structural, Spectral, Antibacterial and Anticancer Investigations of Synthesized Isoxazole Derivatives. Turkish Computational and Theoretical Chemistry 7 3 30–41.
IEEE E. Güney ve K. Sayin, “Structural, Spectral, Antibacterial and Anticancer Investigations of Synthesized Isoxazole Derivatives”, Turkish Comp Theo Chem (TC&TC), c. 7, sy. 3, ss. 30–41, 2023, doi: 10.33435/tcandtc.1270359.
ISNAD Güney, Elif - Sayin, Koray. “Structural, Spectral, Antibacterial and Anticancer Investigations of Synthesized Isoxazole Derivatives”. Turkish Computational and Theoretical Chemistry 7/3 (Eylül 2023), 30-41. https://doi.org/10.33435/tcandtc.1270359.
JAMA Güney E, Sayin K. Structural, Spectral, Antibacterial and Anticancer Investigations of Synthesized Isoxazole Derivatives. Turkish Comp Theo Chem (TC&TC). 2023;7:30–41.
MLA Güney, Elif ve Koray Sayin. “Structural, Spectral, Antibacterial and Anticancer Investigations of Synthesized Isoxazole Derivatives”. Turkish Computational and Theoretical Chemistry, c. 7, sy. 3, 2023, ss. 30-41, doi:10.33435/tcandtc.1270359.
Vancouver Güney E, Sayin K. Structural, Spectral, Antibacterial and Anticancer Investigations of Synthesized Isoxazole Derivatives. Turkish Comp Theo Chem (TC&TC). 2023;7(3):30-41.

Journal Full Title: Turkish Computational and Theoretical Chemistry


Journal Abbreviated Title: Turkish Comp Theo Chem (TC&TC)