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Biyoteknolojik materyallerin kurutulması: Püskürtmeli-dondurarak kurutma işlemi

Yıl 2018, Cilt: 24 Sayı: 7, 1393 - 1402, 28.12.2018

Öz

Üretildiklerinde genellikle sıvı formda olan biyoteknolojik
materyallerin kurutularak toz haline getirilmesi, hem stabilitelerini uzun süre
korumaları hem de depolama ve nakliye masraflarını düşürmesi açısından oldukça
avantajlıdır. Ancak bu ürünlerin kurutulması sırasında hücre canlılığının,
biyolojik aktivitenin veya besleyici değerin kaybolması gibi arzu edilmeyen bir
takım değişiklikler meydana gelebilmektedir. Kendine has avantaj ve
dezavantajları olan püskürtmeli kurutma ve dondurarak kurutma işlemleri
biyoteknolojik materyallerin kurutulması için en sık kullanılan yöntemlerdir.
Püskürtmeli kurutma işleminde yüksek giriş sıcaklıkları nedeniyle ısıya duyarlı
olan materyaller parçalanabilir. Dondurarak kurutma işlemi ise düşük sıcaklık
ve basınçta uzun sürede gerçekleşmesi sebebiyle oldukça yüksek işletme
maliyetine sahiptir. Püskürtmeli-dondurarak kurutma işlemi (PDK), konvansiyonel
dondurarak kurutma ve püskürtmeli kurutma işlemlerinin dezavantajlarını ortadan
kaldırarak her iki yöntemi kombine eden oldukça yeni bir kurutma yöntemidir.
PDK işleminde sıvı besleme ilk aşamada püskürtülerek küçük damlacıklar haline
getirilir. Bu damlacıklar kriyojenik bir ortam ile temas ettirilerek dondurulur
ve düşük sıcaklık ve basınç altında süblimasyon ile kurutulur. Püskürtme işlemi
ile materyalin boyutunun küçültülmesi donma ve kurutma süresini kısaltarak
işletme maliyetini düşürür. Ayrıca, PDK işlemi konvansiyonel dondurarak ve
püskürtmeli kurutma işlemlerine göre daha küçük partikül boyutlu, yüksek
spesifik yüzey alanına sahip, poroz yapıda partiküller ile sonuçlanır. Bu
çalışmada yeni bir kurutma metodu olan PDK işleminin prensibi, avantajları,
uygulama alanları üzerinde durulacak, literatürde yapılmış çalışmalar
derlenecektir.

Kaynakça

  • Adamiec J, Kaminski W, Markowski AS, Strumiłło C. Drying of Biotechnological Products. Editor: Mujumdar AS. Handbook of Industrial Drying, 905-926, Philadelphia, USA, Taylor & Francis Group, LLC, 2006.
  • Law CL, Mujumdar AS. Fluidized bed dryers. Editor: Mujumdar AS. Handbook of Industrial Drying, 173-201, Philadelphia, USA, Taylor & Francis Group, LLC, 2006.
  • Ratti C. “Hot air and freeze-drying of high-value foods: a review”. Journal of Food Engineering, 49, 311-319, 2001.
  • Morgan CA, Herman N, White PA, Vesey G. “Preservation of micro-organisms by drying; a review”. Journal of Microbiological Methods, 66(2), 183-193, 2006.
  • Devahastin S, Suvarnakuta P, Soponronnarit S, Mujumdar AS. “A comparative study of low-pressure superheated steam and vacuum drying of a heat-sensitive material”. Drying Technology, 22(8), 1845-1867, 2004.
  • Filkova I, Huang LX, Mujumdar AS. Industrial Spray Drying Systems. Editor: Mujumdar AS. Handbook of Industrial Drying, 215-254, Philadelphia, USA, Taylor & Francis Group, LLC, 2006.
  • Bhandari BR, Patel KC, Chen XD. Spray drying of food materials-process and product characteristics. Editors: Chen DX, Mujumdar AS. Drying Technologies in Food Processing, 113-157, Oxfodrd, UK, Blackwell Publishing, 2008.
  • Sabarez HT. “Modelling of drying processes for food materials”. Woodhead Publishing Series in Food Science, Technology and Nutrition, 285, 95-122, 2015.
  • Lian WC, Hsiao HC, Chou CC. “Survival of bifidobacteria after spray-drying”. International Journal of Food Microbiology, 74, 79-86, 2002.
  • Capela P, Hay TKC, Shah NP. “Effect of cryoprotectants, prebiotics and microencapsulation on survival of probiotic organisms in yoghurt and freezedried yoghurt”. Food Research International, 39(2), 203-211, 2006.
  • Cui ZW, Li CY, Song CF, Song Y. “Combined microwave-vacuum and freeze drying of carrot and apple chips”. Drying Technology, 26(12), 1517-1523, 2008.
  • Huang LL, Zhang M, Yan WQ, Mujumdar AS, Sun DF. “Effect of coating on post-drying of freeze-dried strawberry pieces”. Journal of Food Engineering, 92(1), 107-111, 2009.
  • Fissore D, Pisano R, Barresi A. “Applying quality-by-design to develop a coffee freeze-drying process”. Journal of Food Engineering, 123, 179-187, 2014.
  • Heldman DR, Hohner GA. “An analysis of atmospheric freeze drying”. Journal of Food Science, 39(1), 147-155, 1974.
  • Anandharamakrishnan C. Experimental and Computational Fluid Dynamics Studies on Spray-Freeze-Drying And Spray-Drying of Whey Proteins. Doctoral Dissertation, Loughborough University, Leichester, UK, 2008.
  • Wanning S, Lamprecht A, Süverkrüp R. “Pharmaceutical spray freeze drying”. International Journal of Pharmaceutics, 488, 136-153, 2015.
  • MacLeod C, McKittrick J, Hindmarsh J, Johns M, Wilson D. “Fundamentals of spray freezing of instant coffee”. Journal of Food Engineering, 74(4), 451-461, 2006.
  • Her JY, Song CS, Lee SJ, Lee KG. “Preparation of kanamycin powder by an optimized spray freeze-drying method”. Powder Technology, 199(2), 159-164, 2010.
  • Ishiwarya SP, Anandharamakrishnan C, Stapley AGF. “Spray-freeze drying-A novel process for the drying of foods and bioproducts”. Trends in Food Science and Technology, 41(2), 161-181, 2015.
  • Sonner C, Maa YF, Lee G. “Spray‐freeze‐drying for protein powder preparation: Particle characterization and a case study with trypsinogen stability”. Journal of Pharmaceutical Sciences, 91(10), 2122-2139, 2002.
  • Yu Z, Johnston KP, Williams RO. “Spray freezing into liquid versus spray-freeze drying: influence of atomization on protein aggregation and biological activity”. European Journal of Pharmaceutical Sciences, 27(1), 9-18, 2006.
  • Engstrom JD, Simpson, DT, Lai ES, Williams RO, Johnston KP. “Morphology of protein particles produced by spray freezing of concentrated solutions”. European Journal of Pharmaceutics and Biopharmaceutics, 65(2), 149-162, 2007.
  • Semyonov D, Ramon O, Kaplun Z, Levin-Brener L, Gurevich N, Shimoni, E. “Microencapsulation of Lactobacillus paracasei by spray freeze drying”. Food Research International, 43(1), 193-202, 2010.
  • D’Addio MS, Chan YGJ, Kwok LCP, Prud’homme KR, Chan HK. “Constant size, variable density aerosol particles by ultrasonic spray freeze drying”. International Journal of Pharmaceutics, 427(2), 185-191, 2012.
  • Parthasarathi S, Anandharamakrishnan C. “Enhancement of oral bioavailability of vitamin E by spray-freeze drying of whey protein microcapsules”. Food and Bioproducts Processing, 100, 469-476, 2016.
  • Teixeira CCC, de Freitas Cabral TP, Tacon LA, Villardi IL, Lanchote AD, de Freitas LAP. “Solid state stability of polyphenols from a plant extract after fluid bed atmospheric-spray-freeze-drying”. Powder Technology, 319, 494-504, 2017.
  • Niwa T, Shimabara H, Danjo K. “Novel spray freeze-drying technique using four-fluid nozzle-development of organic solvent system to expand its application to poorly water soluble drugs”. Chemical and Pharmaceutical Bulletin, 58(2), 195-200, 2010.
  • SonoTek. “Ultrasonic Atomization Technology”. http://www.sono-tek.com/ultrasonic-nozzletechnology/ (31.08.2017).
  • Gao Y, Zhu CL, Zhang XX, Gan L, Gan Y. “Lipid-polymer composite microspheres for colon-specific drug delivery prepared using an ultrasonic spray freeze-drying technique”. Journal of Microencapsulation, 28(6), 549-556, 2011.
  • Nguyen CX, Herberger JD, Burke AD. “Protein powders for encapsulation: A comparison of spray-freeze drying and spray drying of Darbepoetin alfa”. Pharmaceutical Research, 21(3), 507-513, 2004.
  • Burke PA, Klumb LA, Herberger JD, Nguyen XC, Harrell RA, Zordich M. “Poly (lactide-co-glycolide) microsphere formulations of darbepoetin alfa: spray drying is an alternative to encapsulation by spray-freeze drying”. Pharmaceutical Research, 21(3), 500-506, 2004.
  • Al-Hakim K, Wigley G, Stapley AGF. “Phase doppler anemometry studies of spray freezing”. Chemical Engineering Research and Design, 84(12), 1142-1151, 2006.
  • Heller MC, Carpenter JF, Randolph TW. “Protein formulation and lyophilization cycle design: Prevention of damage due to freeze‐concentration induced phase separation”. Biotechnology and Bioengineering, 63(2), 166-174, 1999.
  • Krämer B, Hübner O, Vortisch H, Wöste L, Leisner T, Schwell M, Baumgärtel, H. “Homogeneous nucleation rates of supercooled water measured in single levitated microdroplets”. The Journal of Chemical Physics, 111(14), 6521-6527, 1999.
  • Wang Z, Finlay WH. US. Patent No. 7,007,406. Washington, DC: US. Patent and Trademark Office, 2006.
  • Gusman MI, Johnson SM. US. Patent No. 4,975,415. Washington, DC: US. Patent and Trademark Office, 1990.
  • Gombotz WR, Healy MS, Brown LR, Auer HE. US. Patent No. 6,569,458. Washington, DC, US. Patent and Trademark Office, 2003.
  • Costantino HR, Firouzabadian L, Hogeland K, Wu C, Beganski C, Carrasquillo KG, Tracy MA. “Protein spray-freeze drying-Effect of atomization conditions on particle size and stability”. Pharmaceutical Research, 17(11), 1374-1382, 2000.
  • Costantino HR, Firouzabadian L, Wu C, Carrasquillo KG, Griebenow K, Zale SE, Tracy MA. “Protein spray freeze drying. 2. Effect of formulation variables on particle size and stability”. Journal of Pharmaceutical Sciences, 91(2), 388-395, 2002.
  • Webb SD, Golledge SL, Cleland JL, Carpenter JF, Randolph TW. “Surface adsorption of recombinant human interferon‐γ in lyophilized and spray‐lyophilized formulations”. Journal of Pharmaceutical Sciences, 91(6), 1474-1487, 2002.
  • Hu J, Johnston KP, Williams RO. “Spray freezing into liquid (SFL) particle engineering technology to enhance dissolution of poorly water soluble drugs: organic solvent versus organic/aqueous co-solvent systems”. European Journal of Pharmaceutical Sciences, 20(3), 295-303, 2003.
  • Mumenthaler M, Leuenberger H. “Atmospheric spray-freeze drying: a suitable alternative in freeze-drying technology”. International Journal of Pharmaceutics, 72(2), 97-110, 1991.
  • Meryman HT. “Sublimation freeze-drying without vacuum”. Science, 130(3376), 628-629, 1959.
  • Claussen IC, Ustad TS, Strömmen I, Walde PM. “Atmospheric freeze drying-A review”. Drying Technology, 25(6), 947-957, 2007.
  • Leuenberger H, Plitzko M, Puchkov M. “Spray freeze drying in a fluidized bed at normal and low pressure”. Drying Technology, 24(6), 711-719, 2006.
  • Anandharamakrishnan C, Rielly CD, Stapley AGF. “Spray-freeze-drying of whey proteins at sub-atmospheric pressures”. Dairy Science and Technology, 90(2-3), 321-334, 2010.
  • Mueannoom W, Srisongphan A, Taylor KM, Hauschild S, Gaisford S. “Thermal ink-jet spray freeze-drying for preparation of excipient-free salbutamol sulphate for inhalation”. European Journal of Pharmaceutics and Biopharmaceutics, 80(1), 149-155, 2012.
  • Al-Hakim K, Stapley AGF. “Morphology of spray-dried and spray-freeze-dried whey powders”. 14th International Drying Symposium, Sao Paulo, Brazil, 22-25 August 2004.
  • Rogers S, Wu WD, Saunders J, Chen XD. “Characteristics of milk powders produced by spray freeze drying”. Drying Technology, 26(4), 404-412, 2008.
  • Barron MK, Young TJ, Johnston KP, Williams RO. “Investigation of processing parameters of spray freezing into liquid to prepare polyethylene glycol polymeric particles for drug delivery”. AAPS PharmSciTech, 4(2), 1-13, 2003.
  • Ishwarya SP, Anandharamakrishnan C. “Spray-freeze-drying approach for soluble coffee processing and its effect on quality characteristics”. Journal of Food Engineering, 149, 171-180, 2015.
  • Swetank YH, Karthik P, Anandharamakrishnan C. “Effect of whey protein isolate and b-cyclodextrin wall systems on stability of microencapsulated vanillin by spray-freeze drying method”. Food Chemistry, 174, 16-24, 2015.
  • Fernandes RV, Borges SV, Botrel DA. “Gum arabic/starch/maltodextrin/inulin as wall materials on the microencapsulation of rosemary essential oil”. Carbohydrate Polymers, 101, 524-532, 2014.
  • Koç B, Yılmazer MS, Balkır P, Kaymak-Ertekin F. “Moisture sorption isotherms and storage stability of spray-dried yogurt powder”. Drying Technology, 28(6), 816-822, 2010.
  • Caparino OA, Tang J, Nindo CI, Sablani SS, Powers JR, Fellman JK. “Effect of drying methods on the physical properties and microstructures of mango (Philippine ‘Carabao’var.) powder”. Journal of Food Engineering, 111(1), 135-148, 2012.
  • Rajam R, Anandharamakrishnan C. “Spray freeze drying method for microencapsulation of Lactobacillus plantarum”. Journal of Food Engineering, 166, 95-103, 2015.
  • Yu H, Tran TT, Teo J, Hadinoto K. “Dry powder aerosols of curcumin-chitosan nanoparticle complex prepared by spray freeze drying and their antimicrobial efficacy against common respiratory bacterial pathogens”. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 504, 34-42, 2016.
  • Wanning S, Süverkrüp R, Lamprecht A. “Aerodynamic droplet stream expansion for the production of spray freeze-dried powders” AAPS Pharmaceutical Science and Technology, 18(5), 1760-1769, 2017.
  • Garmise RJ, Staats HF, Hickey AJ. “Novel dry powder preparations of whole inactivated influenza virus for nasal vaccination”. AAPS Pharmaceutical Science and Technology, 8(4), 2-10, 2007.
  • Schiffter H, Condliffe J, Vonhoff S. “Spray-freeze-drying of nanosuspensions: the manufacture of insulin particles for needle-free ballistic powder delivery”. Journal of the Royal Society Interface, 7(4), 483-500, 2010.
  • Kumar R, Kar A. “Microencapsulation of Nutraceuticals Using Spray Freeze Drying Method: A Brief Review”. Indo Global Journal of Pharmaceutical Sciences, 4, 47-51, 2014.
  • van Drooge DJ, Hinrichs WL, Dickhoff BH, Elli MN, Visser MR, Zijlstra GS, Frijlink HW. “Spray freeze drying to produce a stable Δ 9-tetrahydrocannabinol containing inulin-based solid dispersion powder suitable for inhalation”. European journal of Pharmaceutical Sciences, 26(2), 231-240, 2005.
  • Karthik P, Anandharamakrishnan C. “Microencapsulation of docosahexaenoic acid by spray-freeze-drying method and comparison of its stability with spray-drying and freeze-drying methods”. Food and Bioprocess Technology, 6(10), 2780-2790, 2013.
  • Maa YF, Nguyen PA, Sweeney T, Shire SJ, Hsu CC. “Protein inhalation powders: Spray drying vs Spray freze drying”. Pharmaceutical Research, 16(2), 249-254, 1999.
  • Rahmati MR, Vatanara A, Parsian AR, Gilani K, Khosravi KM, Darabi M, Najafabadi AR. “Effect of formulation ingredients on the physical characteristics of salmeterol xinafoate microparticles tailored by spray freeze drying”. Advanced Powder Technology, 24(1), 36-42, 2013.
  • Her JY, Kim MS, Lee KG. “Preparation of probiotic powder by the spray freeze-drying method”. Journal of Food Engineering, 150, 70-74, 2015.
  • Yeom GS, Song CS. “Experimental and numerical investigation of the characteristics of spray-freeze drying for various parameters: Effects of product height, heating plate temperature, and wall temperature”. Drying Technology, 28(2), 165-179, 2010.
  • Yin F, Guo S, Gan Y, Zhang X. “Preparation of redispersible liposomal dry powder using an ultrasonic spray freeze-drying technique for transdermal delivery of human epithelial growth factor”. International Journal of Nanomedicine, 9, 1665-1669, 2014.
  • Ye T, Yu J, Luo Q, Wang S, Chan HK. “Inhalable clarithromycin liposomal dry powders using ultrasonic spray freeze drying”. Powder Technology, 305, 63-70, 2017.
  • Wei S, Ma Y, Luo J, He X, Yue P, Guan Z, Yang M. “Hydroxypropylcellulose as matrix carrier for novel cage-like microparticles prepared by spray-freeze-drying technology”. Carbohydrate Polymers, 157, 953-961, 2017.
  • D’Addio SM, Chan JGY, Kwok PCL, Benson BR, Prud’homme RK, Chan HK. “Aerosol delivery of nanoparticles in uniform mannitol carriers formulated by ultrasonic spray freeze drying”. Pharmaceutical Research, 30(11), 2891-2901, 2013.
  • Bittner B, Kissel T. “Ultrasonic atomization for spray drying: a versatile technique for the preparation of protein loaded biodegradable microspheres”. Journal of Microencapsulation, 16(3), 325-341, 1999.
  • Her JY, Kim MS, Kim MK, Lee KG. “Development of a spray freeze‐drying method for preparation of volatile shiitake mushroom (Lentinus edodes) powder”. International Journal of Food Science and Technology, 50(10), 2222-2228, 2015.
  • Ali ME, Lamprecht A. “Spray freeze drying as an alternative technique for lyophilization of polymeric and lipid-based nanoparticles”. International Journal of Pharmaceutics, 516(1), 170-177, 2017.

Drying of biotechnological materials: Spray-freeze drying

Yıl 2018, Cilt: 24 Sayı: 7, 1393 - 1402, 28.12.2018

Öz

Production of dried powder forms of biotechnological
materials which are generally in liquid form when they are produced is
advantageous in terms of both protecting their stability for a long time and
reducing storage and transportation costs. However, during drying of these
materials, some undesired changes might occur such as loss of cell viability,
biological activity and nutritional value. Spray drying and freeze drying with
their unique advantages and disadvantages are the most commonly used methods
for drying of biotechnological materials. In spray drying, degradation of
heat-labile materials can take place because of the high inlet temperatures.
Freeze drying has high operation costs because of being carried out at low
temperature and low pressure for a long time. Spray-freeze drying (SFD) is a
novel drying method which combines conventional freeze and spray drying by
eliminating the disadvantages of both methods. In SFD process, the liquid feed
solution is first sprayed into small droplets. These droplets are frozen by
contacting with a cryogenic medium and dried by sublimation at low temperature
and pressure. Reduction of the particle size by spraying process reduces the
operation costs by shortening the freezing and drying time. Moreover, the SFD
process results in smaller particle size, higher specific surface area and
porous structured particles than conventional freeze drying and spray drying.
In this study, principles, advantages and application areas of SFD process,
which is a novel drying method, will be emphasized and the studies in the
literature will be reviewed.

Kaynakça

  • Adamiec J, Kaminski W, Markowski AS, Strumiłło C. Drying of Biotechnological Products. Editor: Mujumdar AS. Handbook of Industrial Drying, 905-926, Philadelphia, USA, Taylor & Francis Group, LLC, 2006.
  • Law CL, Mujumdar AS. Fluidized bed dryers. Editor: Mujumdar AS. Handbook of Industrial Drying, 173-201, Philadelphia, USA, Taylor & Francis Group, LLC, 2006.
  • Ratti C. “Hot air and freeze-drying of high-value foods: a review”. Journal of Food Engineering, 49, 311-319, 2001.
  • Morgan CA, Herman N, White PA, Vesey G. “Preservation of micro-organisms by drying; a review”. Journal of Microbiological Methods, 66(2), 183-193, 2006.
  • Devahastin S, Suvarnakuta P, Soponronnarit S, Mujumdar AS. “A comparative study of low-pressure superheated steam and vacuum drying of a heat-sensitive material”. Drying Technology, 22(8), 1845-1867, 2004.
  • Filkova I, Huang LX, Mujumdar AS. Industrial Spray Drying Systems. Editor: Mujumdar AS. Handbook of Industrial Drying, 215-254, Philadelphia, USA, Taylor & Francis Group, LLC, 2006.
  • Bhandari BR, Patel KC, Chen XD. Spray drying of food materials-process and product characteristics. Editors: Chen DX, Mujumdar AS. Drying Technologies in Food Processing, 113-157, Oxfodrd, UK, Blackwell Publishing, 2008.
  • Sabarez HT. “Modelling of drying processes for food materials”. Woodhead Publishing Series in Food Science, Technology and Nutrition, 285, 95-122, 2015.
  • Lian WC, Hsiao HC, Chou CC. “Survival of bifidobacteria after spray-drying”. International Journal of Food Microbiology, 74, 79-86, 2002.
  • Capela P, Hay TKC, Shah NP. “Effect of cryoprotectants, prebiotics and microencapsulation on survival of probiotic organisms in yoghurt and freezedried yoghurt”. Food Research International, 39(2), 203-211, 2006.
  • Cui ZW, Li CY, Song CF, Song Y. “Combined microwave-vacuum and freeze drying of carrot and apple chips”. Drying Technology, 26(12), 1517-1523, 2008.
  • Huang LL, Zhang M, Yan WQ, Mujumdar AS, Sun DF. “Effect of coating on post-drying of freeze-dried strawberry pieces”. Journal of Food Engineering, 92(1), 107-111, 2009.
  • Fissore D, Pisano R, Barresi A. “Applying quality-by-design to develop a coffee freeze-drying process”. Journal of Food Engineering, 123, 179-187, 2014.
  • Heldman DR, Hohner GA. “An analysis of atmospheric freeze drying”. Journal of Food Science, 39(1), 147-155, 1974.
  • Anandharamakrishnan C. Experimental and Computational Fluid Dynamics Studies on Spray-Freeze-Drying And Spray-Drying of Whey Proteins. Doctoral Dissertation, Loughborough University, Leichester, UK, 2008.
  • Wanning S, Lamprecht A, Süverkrüp R. “Pharmaceutical spray freeze drying”. International Journal of Pharmaceutics, 488, 136-153, 2015.
  • MacLeod C, McKittrick J, Hindmarsh J, Johns M, Wilson D. “Fundamentals of spray freezing of instant coffee”. Journal of Food Engineering, 74(4), 451-461, 2006.
  • Her JY, Song CS, Lee SJ, Lee KG. “Preparation of kanamycin powder by an optimized spray freeze-drying method”. Powder Technology, 199(2), 159-164, 2010.
  • Ishiwarya SP, Anandharamakrishnan C, Stapley AGF. “Spray-freeze drying-A novel process for the drying of foods and bioproducts”. Trends in Food Science and Technology, 41(2), 161-181, 2015.
  • Sonner C, Maa YF, Lee G. “Spray‐freeze‐drying for protein powder preparation: Particle characterization and a case study with trypsinogen stability”. Journal of Pharmaceutical Sciences, 91(10), 2122-2139, 2002.
  • Yu Z, Johnston KP, Williams RO. “Spray freezing into liquid versus spray-freeze drying: influence of atomization on protein aggregation and biological activity”. European Journal of Pharmaceutical Sciences, 27(1), 9-18, 2006.
  • Engstrom JD, Simpson, DT, Lai ES, Williams RO, Johnston KP. “Morphology of protein particles produced by spray freezing of concentrated solutions”. European Journal of Pharmaceutics and Biopharmaceutics, 65(2), 149-162, 2007.
  • Semyonov D, Ramon O, Kaplun Z, Levin-Brener L, Gurevich N, Shimoni, E. “Microencapsulation of Lactobacillus paracasei by spray freeze drying”. Food Research International, 43(1), 193-202, 2010.
  • D’Addio MS, Chan YGJ, Kwok LCP, Prud’homme KR, Chan HK. “Constant size, variable density aerosol particles by ultrasonic spray freeze drying”. International Journal of Pharmaceutics, 427(2), 185-191, 2012.
  • Parthasarathi S, Anandharamakrishnan C. “Enhancement of oral bioavailability of vitamin E by spray-freeze drying of whey protein microcapsules”. Food and Bioproducts Processing, 100, 469-476, 2016.
  • Teixeira CCC, de Freitas Cabral TP, Tacon LA, Villardi IL, Lanchote AD, de Freitas LAP. “Solid state stability of polyphenols from a plant extract after fluid bed atmospheric-spray-freeze-drying”. Powder Technology, 319, 494-504, 2017.
  • Niwa T, Shimabara H, Danjo K. “Novel spray freeze-drying technique using four-fluid nozzle-development of organic solvent system to expand its application to poorly water soluble drugs”. Chemical and Pharmaceutical Bulletin, 58(2), 195-200, 2010.
  • SonoTek. “Ultrasonic Atomization Technology”. http://www.sono-tek.com/ultrasonic-nozzletechnology/ (31.08.2017).
  • Gao Y, Zhu CL, Zhang XX, Gan L, Gan Y. “Lipid-polymer composite microspheres for colon-specific drug delivery prepared using an ultrasonic spray freeze-drying technique”. Journal of Microencapsulation, 28(6), 549-556, 2011.
  • Nguyen CX, Herberger JD, Burke AD. “Protein powders for encapsulation: A comparison of spray-freeze drying and spray drying of Darbepoetin alfa”. Pharmaceutical Research, 21(3), 507-513, 2004.
  • Burke PA, Klumb LA, Herberger JD, Nguyen XC, Harrell RA, Zordich M. “Poly (lactide-co-glycolide) microsphere formulations of darbepoetin alfa: spray drying is an alternative to encapsulation by spray-freeze drying”. Pharmaceutical Research, 21(3), 500-506, 2004.
  • Al-Hakim K, Wigley G, Stapley AGF. “Phase doppler anemometry studies of spray freezing”. Chemical Engineering Research and Design, 84(12), 1142-1151, 2006.
  • Heller MC, Carpenter JF, Randolph TW. “Protein formulation and lyophilization cycle design: Prevention of damage due to freeze‐concentration induced phase separation”. Biotechnology and Bioengineering, 63(2), 166-174, 1999.
  • Krämer B, Hübner O, Vortisch H, Wöste L, Leisner T, Schwell M, Baumgärtel, H. “Homogeneous nucleation rates of supercooled water measured in single levitated microdroplets”. The Journal of Chemical Physics, 111(14), 6521-6527, 1999.
  • Wang Z, Finlay WH. US. Patent No. 7,007,406. Washington, DC: US. Patent and Trademark Office, 2006.
  • Gusman MI, Johnson SM. US. Patent No. 4,975,415. Washington, DC: US. Patent and Trademark Office, 1990.
  • Gombotz WR, Healy MS, Brown LR, Auer HE. US. Patent No. 6,569,458. Washington, DC, US. Patent and Trademark Office, 2003.
  • Costantino HR, Firouzabadian L, Hogeland K, Wu C, Beganski C, Carrasquillo KG, Tracy MA. “Protein spray-freeze drying-Effect of atomization conditions on particle size and stability”. Pharmaceutical Research, 17(11), 1374-1382, 2000.
  • Costantino HR, Firouzabadian L, Wu C, Carrasquillo KG, Griebenow K, Zale SE, Tracy MA. “Protein spray freeze drying. 2. Effect of formulation variables on particle size and stability”. Journal of Pharmaceutical Sciences, 91(2), 388-395, 2002.
  • Webb SD, Golledge SL, Cleland JL, Carpenter JF, Randolph TW. “Surface adsorption of recombinant human interferon‐γ in lyophilized and spray‐lyophilized formulations”. Journal of Pharmaceutical Sciences, 91(6), 1474-1487, 2002.
  • Hu J, Johnston KP, Williams RO. “Spray freezing into liquid (SFL) particle engineering technology to enhance dissolution of poorly water soluble drugs: organic solvent versus organic/aqueous co-solvent systems”. European Journal of Pharmaceutical Sciences, 20(3), 295-303, 2003.
  • Mumenthaler M, Leuenberger H. “Atmospheric spray-freeze drying: a suitable alternative in freeze-drying technology”. International Journal of Pharmaceutics, 72(2), 97-110, 1991.
  • Meryman HT. “Sublimation freeze-drying without vacuum”. Science, 130(3376), 628-629, 1959.
  • Claussen IC, Ustad TS, Strömmen I, Walde PM. “Atmospheric freeze drying-A review”. Drying Technology, 25(6), 947-957, 2007.
  • Leuenberger H, Plitzko M, Puchkov M. “Spray freeze drying in a fluidized bed at normal and low pressure”. Drying Technology, 24(6), 711-719, 2006.
  • Anandharamakrishnan C, Rielly CD, Stapley AGF. “Spray-freeze-drying of whey proteins at sub-atmospheric pressures”. Dairy Science and Technology, 90(2-3), 321-334, 2010.
  • Mueannoom W, Srisongphan A, Taylor KM, Hauschild S, Gaisford S. “Thermal ink-jet spray freeze-drying for preparation of excipient-free salbutamol sulphate for inhalation”. European Journal of Pharmaceutics and Biopharmaceutics, 80(1), 149-155, 2012.
  • Al-Hakim K, Stapley AGF. “Morphology of spray-dried and spray-freeze-dried whey powders”. 14th International Drying Symposium, Sao Paulo, Brazil, 22-25 August 2004.
  • Rogers S, Wu WD, Saunders J, Chen XD. “Characteristics of milk powders produced by spray freeze drying”. Drying Technology, 26(4), 404-412, 2008.
  • Barron MK, Young TJ, Johnston KP, Williams RO. “Investigation of processing parameters of spray freezing into liquid to prepare polyethylene glycol polymeric particles for drug delivery”. AAPS PharmSciTech, 4(2), 1-13, 2003.
  • Ishwarya SP, Anandharamakrishnan C. “Spray-freeze-drying approach for soluble coffee processing and its effect on quality characteristics”. Journal of Food Engineering, 149, 171-180, 2015.
  • Swetank YH, Karthik P, Anandharamakrishnan C. “Effect of whey protein isolate and b-cyclodextrin wall systems on stability of microencapsulated vanillin by spray-freeze drying method”. Food Chemistry, 174, 16-24, 2015.
  • Fernandes RV, Borges SV, Botrel DA. “Gum arabic/starch/maltodextrin/inulin as wall materials on the microencapsulation of rosemary essential oil”. Carbohydrate Polymers, 101, 524-532, 2014.
  • Koç B, Yılmazer MS, Balkır P, Kaymak-Ertekin F. “Moisture sorption isotherms and storage stability of spray-dried yogurt powder”. Drying Technology, 28(6), 816-822, 2010.
  • Caparino OA, Tang J, Nindo CI, Sablani SS, Powers JR, Fellman JK. “Effect of drying methods on the physical properties and microstructures of mango (Philippine ‘Carabao’var.) powder”. Journal of Food Engineering, 111(1), 135-148, 2012.
  • Rajam R, Anandharamakrishnan C. “Spray freeze drying method for microencapsulation of Lactobacillus plantarum”. Journal of Food Engineering, 166, 95-103, 2015.
  • Yu H, Tran TT, Teo J, Hadinoto K. “Dry powder aerosols of curcumin-chitosan nanoparticle complex prepared by spray freeze drying and their antimicrobial efficacy against common respiratory bacterial pathogens”. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 504, 34-42, 2016.
  • Wanning S, Süverkrüp R, Lamprecht A. “Aerodynamic droplet stream expansion for the production of spray freeze-dried powders” AAPS Pharmaceutical Science and Technology, 18(5), 1760-1769, 2017.
  • Garmise RJ, Staats HF, Hickey AJ. “Novel dry powder preparations of whole inactivated influenza virus for nasal vaccination”. AAPS Pharmaceutical Science and Technology, 8(4), 2-10, 2007.
  • Schiffter H, Condliffe J, Vonhoff S. “Spray-freeze-drying of nanosuspensions: the manufacture of insulin particles for needle-free ballistic powder delivery”. Journal of the Royal Society Interface, 7(4), 483-500, 2010.
  • Kumar R, Kar A. “Microencapsulation of Nutraceuticals Using Spray Freeze Drying Method: A Brief Review”. Indo Global Journal of Pharmaceutical Sciences, 4, 47-51, 2014.
  • van Drooge DJ, Hinrichs WL, Dickhoff BH, Elli MN, Visser MR, Zijlstra GS, Frijlink HW. “Spray freeze drying to produce a stable Δ 9-tetrahydrocannabinol containing inulin-based solid dispersion powder suitable for inhalation”. European journal of Pharmaceutical Sciences, 26(2), 231-240, 2005.
  • Karthik P, Anandharamakrishnan C. “Microencapsulation of docosahexaenoic acid by spray-freeze-drying method and comparison of its stability with spray-drying and freeze-drying methods”. Food and Bioprocess Technology, 6(10), 2780-2790, 2013.
  • Maa YF, Nguyen PA, Sweeney T, Shire SJ, Hsu CC. “Protein inhalation powders: Spray drying vs Spray freze drying”. Pharmaceutical Research, 16(2), 249-254, 1999.
  • Rahmati MR, Vatanara A, Parsian AR, Gilani K, Khosravi KM, Darabi M, Najafabadi AR. “Effect of formulation ingredients on the physical characteristics of salmeterol xinafoate microparticles tailored by spray freeze drying”. Advanced Powder Technology, 24(1), 36-42, 2013.
  • Her JY, Kim MS, Lee KG. “Preparation of probiotic powder by the spray freeze-drying method”. Journal of Food Engineering, 150, 70-74, 2015.
  • Yeom GS, Song CS. “Experimental and numerical investigation of the characteristics of spray-freeze drying for various parameters: Effects of product height, heating plate temperature, and wall temperature”. Drying Technology, 28(2), 165-179, 2010.
  • Yin F, Guo S, Gan Y, Zhang X. “Preparation of redispersible liposomal dry powder using an ultrasonic spray freeze-drying technique for transdermal delivery of human epithelial growth factor”. International Journal of Nanomedicine, 9, 1665-1669, 2014.
  • Ye T, Yu J, Luo Q, Wang S, Chan HK. “Inhalable clarithromycin liposomal dry powders using ultrasonic spray freeze drying”. Powder Technology, 305, 63-70, 2017.
  • Wei S, Ma Y, Luo J, He X, Yue P, Guan Z, Yang M. “Hydroxypropylcellulose as matrix carrier for novel cage-like microparticles prepared by spray-freeze-drying technology”. Carbohydrate Polymers, 157, 953-961, 2017.
  • D’Addio SM, Chan JGY, Kwok PCL, Benson BR, Prud’homme RK, Chan HK. “Aerosol delivery of nanoparticles in uniform mannitol carriers formulated by ultrasonic spray freeze drying”. Pharmaceutical Research, 30(11), 2891-2901, 2013.
  • Bittner B, Kissel T. “Ultrasonic atomization for spray drying: a versatile technique for the preparation of protein loaded biodegradable microspheres”. Journal of Microencapsulation, 16(3), 325-341, 1999.
  • Her JY, Kim MS, Kim MK, Lee KG. “Development of a spray freeze‐drying method for preparation of volatile shiitake mushroom (Lentinus edodes) powder”. International Journal of Food Science and Technology, 50(10), 2222-2228, 2015.
  • Ali ME, Lamprecht A. “Spray freeze drying as an alternative technique for lyophilization of polymeric and lipid-based nanoparticles”. International Journal of Pharmaceutics, 516(1), 170-177, 2017.
Toplam 74 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Mühendislik
Bölüm Derleme
Yazarlar

Hilal İşleroğlu 0000-0002-4338-9242

İzzet Türker Bu kişi benim 0000-0003-0107-1962

Banu Koç 0000-0002-1239-3353

Mehmet Tokatlı 0000-0001-6264-9102

Yayımlanma Tarihi 28 Aralık 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 24 Sayı: 7

Kaynak Göster

APA İşleroğlu, H., Türker, İ., Koç, B., Tokatlı, M. (2018). Biyoteknolojik materyallerin kurutulması: Püskürtmeli-dondurarak kurutma işlemi. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi, 24(7), 1393-1402.
AMA İşleroğlu H, Türker İ, Koç B, Tokatlı M. Biyoteknolojik materyallerin kurutulması: Püskürtmeli-dondurarak kurutma işlemi. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi. Aralık 2018;24(7):1393-1402.
Chicago İşleroğlu, Hilal, İzzet Türker, Banu Koç, ve Mehmet Tokatlı. “Biyoteknolojik Materyallerin kurutulması: Püskürtmeli-Dondurarak Kurutma işlemi”. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi 24, sy. 7 (Aralık 2018): 1393-1402.
EndNote İşleroğlu H, Türker İ, Koç B, Tokatlı M (01 Aralık 2018) Biyoteknolojik materyallerin kurutulması: Püskürtmeli-dondurarak kurutma işlemi. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi 24 7 1393–1402.
IEEE H. İşleroğlu, İ. Türker, B. Koç, ve M. Tokatlı, “Biyoteknolojik materyallerin kurutulması: Püskürtmeli-dondurarak kurutma işlemi”, Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi, c. 24, sy. 7, ss. 1393–1402, 2018.
ISNAD İşleroğlu, Hilal vd. “Biyoteknolojik Materyallerin kurutulması: Püskürtmeli-Dondurarak Kurutma işlemi”. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi 24/7 (Aralık 2018), 1393-1402.
JAMA İşleroğlu H, Türker İ, Koç B, Tokatlı M. Biyoteknolojik materyallerin kurutulması: Püskürtmeli-dondurarak kurutma işlemi. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi. 2018;24:1393–1402.
MLA İşleroğlu, Hilal vd. “Biyoteknolojik Materyallerin kurutulması: Püskürtmeli-Dondurarak Kurutma işlemi”. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi, c. 24, sy. 7, 2018, ss. 1393-02.
Vancouver İşleroğlu H, Türker İ, Koç B, Tokatlı M. Biyoteknolojik materyallerin kurutulması: Püskürtmeli-dondurarak kurutma işlemi. Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi. 2018;24(7):1393-402.





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