Analysis of Trace Elements, Anticholinesterase Activity and ADME/Tox Profiling of some Achillea Species

Duygu Taşkın; Talip Şahin; Mücahit Özdemir; Bahattin Yalcin

doi:10.18596/jotcsa.849654

Araştırma Makalesi

Analysis of Trace Elements, Anticholinesterase Activity and ADME/Tox Profiling of some Achillea Species

Yıl 2021, Cilt: 8 Sayı: 1, 329 - 342, 28.02.2021

Duygu Taşkın Talip Şahin Mücahit Özdemir Bahattin Yalcin

https://doi.org/10.18596/jotcsa.849654

Öz

In this study, the anti-cholinesterase activities of different extracts of Achillea lycaonica, A. vermicularis and A. nobilis L. subsp. neilreichii (Kerner) Formanek species were examined and then trace elements (Al, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Cd, and Pb) of the plants were analysed by ICP-MS. The pharmacokinetic properties of the phenolic compounds of these plants previously analyzed by us and the ADME-Tox (absorption, distribution, metabolism, excretion, and toxicity) profiles of the trace elements we identified in this study were estimated. According to the data obtained, it was determined that all three plants showed high acetyl-cholinesterase inhibition activity. The concentration of trace elements was lower than that declared by WHO, except for the A. lycaonica. It was determined that V, Cr, Fe, Co, and As metals in A. lycaonica exceeded the limit values determined by WHO. According to ADMET estimates, it is thought that the toxic values of all three plants are not high, and therefore the use of A. nobilis and A. vermicularis plants does not pose any health risk but A lycaonica should be used carefully due to the heavy metals.

Anahtar Kelimeler

Phenolic compounds, ADMET, ICP-MS, cholinesterase inhibitory

Teşekkür

Thanks to Dr. Ismail Senkardes, Dr.Ahmet Dogan, and Dr. Turan Arabaci, who identified the plants.

Kaynakça

1. Turkmenoglu FP, Agar OT, Akaydin G, Hayran M, Demirci B. Characterization of volatile compounds of eleven Achillea species from Turkey and biological activities of essential oil and methanol extract of A. hamzaoglui Arabacı & Budak. Molecules. 2015;20(6):1432-11458.
2. Karabay-Yavasoglu NU, Karamenderes C, Baykan S, Apaydın S. Antinociceptive and anti-inflammatory activities and acute toxicity of Achillea nobilis subsp. neilreichii extract in mice and rats. Pharmaceutical Biology. 2007;45(2):162-168.
3. Azaz AD, Arabacı T, Sangun MK, Yıldız B. Composition and the in vitro antimicrobial activities of the essential oils of Achillea wilhelmsii C. Koch. and Achillea lycaonica Boiss. & Heldr. Asian Journal of Chemistry. 2008;20(2):1238-44.
4. Behçet L, Arık M. An ethnobotanical investigation in east Anatolia (Turkey). Turkish Journal of Agricultural and Natural Sciences. 2013;2(1):1-89.
5. Bulut G, Biçer M, Tuzlacı E. The folk medicinal plants of Yüksekova (Hakkari- Turkey). Journal of Faculty of Pharmacy of Istanbul University. 2016;46(2):15-124.
6. Abugassa IO, Bashir AT, Doubali K, Etwir RH, Abu-Enawel M, Abugassa SO. Characterization of trace elements in medicinal herbs by instrumental neutron activation analysis. Journal of Radioanalytical and Nuclear Chemistry. 2008;278(3):559–563.
7. Karadas C, Kara D. Chemometric approach to evaluate trace metal concentrations in some spices and herbs. Food Chemistry. 2012;130(1):196–202.
8. Tokalıoglu S. Determination of trace elements in commonly consumed medicinal herbs by ICP-MS and ultivariate analysis. Food Chemistry. 2012;134(4):2504–2508.
9. Klaric DA, Klaric I, Mornar A, Velic D, Velic N. Blackberry wines mineral and heavy metal content determination after dry ashing: multivariate data analysis as a tool for fruit wine quality control. International Journal of Food Sciences and Nutrition. 2016;67(5):514-523.
10. Basgel S, Erdemoglu SB. Determination of mineral and trace elements in some medicinal herbs and their infusions consumed in Turkey. Science of The Total Environment. 2006;359(1-3):82-9.
11. AL-Oud SS. Heavy metal contents in tea and herb leaves. Pakistan Journal of Biological Sciences. 2003;6(3):208–212.
12. Nookabkaew S, Rangkadilok N, Satayavivad J. Determination of trace elements in herbal tea products and their infusions consumed in Thailand. Journal of Agricultural and Food Chemistry. 2006;54(18):6939-44.
13. Bora T, Aksoy C, Tunay Z, Aydın F. Determination of trace elements in illicit spice samples by using ICP-MS. Microchemical Journal. 2015;123:179-184.
14. Pires DEV, Blundell TL, Ascher DB. pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures. Journal of Medicinal Chemistry. 2015;58(9):4066-4072.
15. Ellman GL, Courtney KD, Andress V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology. 1961;7(2):88–95.
16. Patlewicz G, Jeliazkova N, Safford RJ, Worth AP, Aleksiev B. An evaluation of the implementation of the Cramer classification scheme in the Toxtree software. SAR and QSAR in Environmental Research. 2008;19(5-6):495–524.
17. Taşkın T, Taşkın D, Rayaman E, Dikpınar T, Selçuk SS, Arabacı T. Characterization of the Biological Activity and Phenolics in Achillea lycaonica. Analytical Letters. 2018;51(1-2):33-48.
18. Taşkın D, Taşkın T, Rayaman E. Phenolic composition and biological properties of Achillea nobilis L. subsp. neilreichii (Kerner) Formanek. Industrial Crops & Products. 2018; 11: 555-562.
19. Taşkın T, Balkan IE, Taşkın D, Dogan A. Characterization of Phenolic Constituents and Pharmacological Activity of Achillea vermicularis. Indian Journal of Pharmaceutical Sciences. 2019;81(2):293-301.
20. Yener I. Trace Element Analysis in Some Plants Species by Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES). Journal of the Institute of Science and Technology. 2019;9(3):1492-1502.
21. Abou-Arab AAK, Abou-Donia MA. Heavy metals in Egyptian spices and medicinal plants and the effect of processing on their levels Journal of Agricultural and Food Chemistry. 2000;48(6):2300–2304.
22. Ebrahim AM, Eltayeb MH, Khalid H, Mohamed H, Abdalla W, Grill P, Michalke B. Study on selected trace elements and heavy metals in some popular medicinal plants from Sudan. Journal of Natural Medicines. 2012;66:671–679.
23. Khan SA, Khan L, Hussain I, Marwat KB, Akhtar N. Profıle Of Heavy Metals In Selected Medıcınal Plants. Pakıstan Journal of Weed Scıence Research. 2008;14(1-2):101-110.
24. Karahan F, Ozyigit II, Saracoglu IA, Yalcin IE, Hocaoglu-Ozyigit A, Ilcim A. Heavy Metal Levels and Mineral Nutrient Status in Different Parts of Various Medicinal Plants Collected from Eastern Mediterranean Region of Turkey. Biological Trace Element Research. 2020;197:316–329.
25. Baye H, Hymete A. Levels of Heavy Metals in Common Medicinal Plants Collected from Environmentally Different Sites. Middle-East Journal of Scientific Research. 2013;13 (7):938-943.
26. Sarma H, Deka S, Deka H, Saikia RR. Accumulation of Heavy Metals in Selected Medicinal Plants. Reviews of Environmental Contamination and Toxicology. 2011;214:63-86.
27. WHO. WHO Guidelines for Assessing Quality of Herbal Medicines with Reference to Contaminants and Residues. World Health Organization, Geneva, Switzerland, 2006.
28. Dghaim R, Khatib SA, Rasool H, Khan MA. Determination of Heavy Metals Concentration in Traditional Herbs Commonly Consumed in the United Arab Emirates. Journal of Environmental and Public Health. 2015;2015(4):1-6.
29. Zamir R, Hosen A, Ullah MO, Nahar N. Microbial and Heavy Metal Contaminant of Antidiabetic Herbal Preparations Formulated in Bangladesh. Journal of Evidence-Based Complementary and Alternative Medicine. 2015;2015(3).1-9.
30. Singh NM, Singh NR. A Quantitative Analysis of Heavy Metals in Vegetables Grown At Kakching-Wabagai Area, Thoubal District Manipur. Indıan Journal Of Research. 2014;3(6).1-3.
31. Hayta Ş, Avcil N. Bitlis Katı Atık Tesisi Çevresindeki Hypericum scabrum L., Achillea vermicularis Trin, Anchusa azurea Miller var. azurea Gard. Dict. Bitkilerinin Ağır Metal İçeriklerinin Belirlenmesi. Bitlis Eren University Journal of Science and Technology. 2019;8(4):1533-1544.
32. Shirkhanloo H, Mirzahosseini SAH, Shirkhanloo N, Moussavi-Najarkola SA, Farahani H. The evaluation and determination of heavy metals pollution in edible vegetables, water and soil in the south of Tehran province by GIS. Archives of Environmental Protection. 2015;41(2):64–74.
33. Grabowski T, Jaroszewski JJ. Bioavailability of veterinary drugs in vivo and in silico. Journal of Veterinary Pharmacology and Therapeutics. 2009; 32: 249-257.

Yıl 2021, Cilt: 8 Sayı: 1, 329 - 342, 28.02.2021

Duygu Taşkın Talip Şahin Mücahit Özdemir Bahattin Yalcin

https://doi.org/10.18596/jotcsa.849654

Öz

Kaynakça

1. Turkmenoglu FP, Agar OT, Akaydin G, Hayran M, Demirci B. Characterization of volatile compounds of eleven Achillea species from Turkey and biological activities of essential oil and methanol extract of A. hamzaoglui Arabacı & Budak. Molecules. 2015;20(6):1432-11458.
2. Karabay-Yavasoglu NU, Karamenderes C, Baykan S, Apaydın S. Antinociceptive and anti-inflammatory activities and acute toxicity of Achillea nobilis subsp. neilreichii extract in mice and rats. Pharmaceutical Biology. 2007;45(2):162-168.
3. Azaz AD, Arabacı T, Sangun MK, Yıldız B. Composition and the in vitro antimicrobial activities of the essential oils of Achillea wilhelmsii C. Koch. and Achillea lycaonica Boiss. & Heldr. Asian Journal of Chemistry. 2008;20(2):1238-44.
4. Behçet L, Arık M. An ethnobotanical investigation in east Anatolia (Turkey). Turkish Journal of Agricultural and Natural Sciences. 2013;2(1):1-89.
5. Bulut G, Biçer M, Tuzlacı E. The folk medicinal plants of Yüksekova (Hakkari- Turkey). Journal of Faculty of Pharmacy of Istanbul University. 2016;46(2):15-124.
6. Abugassa IO, Bashir AT, Doubali K, Etwir RH, Abu-Enawel M, Abugassa SO. Characterization of trace elements in medicinal herbs by instrumental neutron activation analysis. Journal of Radioanalytical and Nuclear Chemistry. 2008;278(3):559–563.
7. Karadas C, Kara D. Chemometric approach to evaluate trace metal concentrations in some spices and herbs. Food Chemistry. 2012;130(1):196–202.
8. Tokalıoglu S. Determination of trace elements in commonly consumed medicinal herbs by ICP-MS and ultivariate analysis. Food Chemistry. 2012;134(4):2504–2508.
9. Klaric DA, Klaric I, Mornar A, Velic D, Velic N. Blackberry wines mineral and heavy metal content determination after dry ashing: multivariate data analysis as a tool for fruit wine quality control. International Journal of Food Sciences and Nutrition. 2016;67(5):514-523.
10. Basgel S, Erdemoglu SB. Determination of mineral and trace elements in some medicinal herbs and their infusions consumed in Turkey. Science of The Total Environment. 2006;359(1-3):82-9.
11. AL-Oud SS. Heavy metal contents in tea and herb leaves. Pakistan Journal of Biological Sciences. 2003;6(3):208–212.
12. Nookabkaew S, Rangkadilok N, Satayavivad J. Determination of trace elements in herbal tea products and their infusions consumed in Thailand. Journal of Agricultural and Food Chemistry. 2006;54(18):6939-44.
13. Bora T, Aksoy C, Tunay Z, Aydın F. Determination of trace elements in illicit spice samples by using ICP-MS. Microchemical Journal. 2015;123:179-184.
14. Pires DEV, Blundell TL, Ascher DB. pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures. Journal of Medicinal Chemistry. 2015;58(9):4066-4072.
15. Ellman GL, Courtney KD, Andress V, Featherstone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology. 1961;7(2):88–95.
16. Patlewicz G, Jeliazkova N, Safford RJ, Worth AP, Aleksiev B. An evaluation of the implementation of the Cramer classification scheme in the Toxtree software. SAR and QSAR in Environmental Research. 2008;19(5-6):495–524.
17. Taşkın T, Taşkın D, Rayaman E, Dikpınar T, Selçuk SS, Arabacı T. Characterization of the Biological Activity and Phenolics in Achillea lycaonica. Analytical Letters. 2018;51(1-2):33-48.
18. Taşkın D, Taşkın T, Rayaman E. Phenolic composition and biological properties of Achillea nobilis L. subsp. neilreichii (Kerner) Formanek. Industrial Crops & Products. 2018; 11: 555-562.
19. Taşkın T, Balkan IE, Taşkın D, Dogan A. Characterization of Phenolic Constituents and Pharmacological Activity of Achillea vermicularis. Indian Journal of Pharmaceutical Sciences. 2019;81(2):293-301.
20. Yener I. Trace Element Analysis in Some Plants Species by Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES). Journal of the Institute of Science and Technology. 2019;9(3):1492-1502.
21. Abou-Arab AAK, Abou-Donia MA. Heavy metals in Egyptian spices and medicinal plants and the effect of processing on their levels Journal of Agricultural and Food Chemistry. 2000;48(6):2300–2304.
22. Ebrahim AM, Eltayeb MH, Khalid H, Mohamed H, Abdalla W, Grill P, Michalke B. Study on selected trace elements and heavy metals in some popular medicinal plants from Sudan. Journal of Natural Medicines. 2012;66:671–679.
23. Khan SA, Khan L, Hussain I, Marwat KB, Akhtar N. Profıle Of Heavy Metals In Selected Medıcınal Plants. Pakıstan Journal of Weed Scıence Research. 2008;14(1-2):101-110.
24. Karahan F, Ozyigit II, Saracoglu IA, Yalcin IE, Hocaoglu-Ozyigit A, Ilcim A. Heavy Metal Levels and Mineral Nutrient Status in Different Parts of Various Medicinal Plants Collected from Eastern Mediterranean Region of Turkey. Biological Trace Element Research. 2020;197:316–329.
25. Baye H, Hymete A. Levels of Heavy Metals in Common Medicinal Plants Collected from Environmentally Different Sites. Middle-East Journal of Scientific Research. 2013;13 (7):938-943.
26. Sarma H, Deka S, Deka H, Saikia RR. Accumulation of Heavy Metals in Selected Medicinal Plants. Reviews of Environmental Contamination and Toxicology. 2011;214:63-86.
27. WHO. WHO Guidelines for Assessing Quality of Herbal Medicines with Reference to Contaminants and Residues. World Health Organization, Geneva, Switzerland, 2006.
28. Dghaim R, Khatib SA, Rasool H, Khan MA. Determination of Heavy Metals Concentration in Traditional Herbs Commonly Consumed in the United Arab Emirates. Journal of Environmental and Public Health. 2015;2015(4):1-6.
29. Zamir R, Hosen A, Ullah MO, Nahar N. Microbial and Heavy Metal Contaminant of Antidiabetic Herbal Preparations Formulated in Bangladesh. Journal of Evidence-Based Complementary and Alternative Medicine. 2015;2015(3).1-9.
30. Singh NM, Singh NR. A Quantitative Analysis of Heavy Metals in Vegetables Grown At Kakching-Wabagai Area, Thoubal District Manipur. Indıan Journal Of Research. 2014;3(6).1-3.
31. Hayta Ş, Avcil N. Bitlis Katı Atık Tesisi Çevresindeki Hypericum scabrum L., Achillea vermicularis Trin, Anchusa azurea Miller var. azurea Gard. Dict. Bitkilerinin Ağır Metal İçeriklerinin Belirlenmesi. Bitlis Eren University Journal of Science and Technology. 2019;8(4):1533-1544.
32. Shirkhanloo H, Mirzahosseini SAH, Shirkhanloo N, Moussavi-Najarkola SA, Farahani H. The evaluation and determination of heavy metals pollution in edible vegetables, water and soil in the south of Tehran province by GIS. Archives of Environmental Protection. 2015;41(2):64–74.
33. Grabowski T, Jaroszewski JJ. Bioavailability of veterinary drugs in vivo and in silico. Journal of Veterinary Pharmacology and Therapeutics. 2009; 32: 249-257.

Toplam 33 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Konular	Analitik Kimya
Bölüm	Makaleler
Yazarlar	Duygu Taşkın 0000-0002-5279-0900 Talip Şahin Bu kişi benim 0000-0002-1031-9715 Mücahit Özdemir 0000-0002-0840-4953 Bahattin Yalcin 0000-0003-4448-1101
Yayımlanma Tarihi	28 Şubat 2021
Gönderilme Tarihi	29 Aralık 2020
Kabul Tarihi	17 Ocak 2021
Yayımlandığı Sayı	Yıl 2021 Cilt: 8 Sayı: 1

Kaynak Göster

Vancouver	Taşkın D, Şahin T, Özdemir M, Yalcin B. Analysis of Trace Elements, Anticholinesterase Activity and ADME/Tox Profiling of some Achillea Species. JOTCSA. 2021;8(1):329-42.

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