EN
Carbon Radiotheraphy For Head and Neck Cancer: Dosimetric Comparison with Photon Plans
Abstract
Radiation therapy is one of the most widely used treatment methods for tumors. The therapeutic use of carbon ions is more advantageous than other radiotherapy techniquies especially photon-based irradiation due to its physical properties and radiobiological effects, and therefore it has received more attention. One of the most important reasons for that carbon ion beams are more effective than photon beams while minimizing the dose in the normal tissues around the target, it offers an improved dose distribution that leads to sufficient dose concentration in tumors. In addition, the carbon beam reaches its maximum at the end of its range, which increases with depth, and due to this feature, it provides a higher biological efficiency. In radiotherapy studies, Monte Carlo simulation is widely used to determine the dose distributions and to obtain the correct properties of the beams. With MC simulation, it helps to understand the relative biological efficiency as well as the spatial model of energy storages. In this study, a geometry with critical organs (skull, brain, nasopharynx and thyroid) based on a MIRD phantom was modeled with the Monte Carlo simulation tool GATE (vGATE 9.0). In this experiment, the tumor was irradiated with different carbon beam energies and photon beams. The aim is to calculate the energy accumulations in the region and surrounding organs with the MC method, and as a result, to show the dosimetric advantages of carbon radiotherapy over photon radiotherapy.
Keywords
References
- [1] Yaprak G., Evaluation of radiological and biochemical methods in the late term toxicity of carotic artery, thyroid gland and temporal lob after radiotherapy in patients with nasopharyngeal cancer,master thesis,Ministry of Health-Dr.Lutfi Kırdar Kartal Training and Research Hospital, Radiology Oncology Department, (2007).
- [2] Mohamad O., Sishc B.J., Saha J., Pompos A., Rahimi A., Story M.D., DavisA., Kim D.W.N., Carbon Ion Radiotherapy:A Review of Clinical Experiences and Preclinical,with an Emphasis on DNA Damage/Repair, DNA Repair Pathways in Cancer, 9 (6) (2017) 66.
- [3] Kim J., Park J.M., Wu H.G.,Carbon Ion Therapy: A Review of an Advanced Technology, Progress in Medical Physics,31 (3) (2020) 71-80.
- [4] Andreo P., Monte Carlo simulations in radiotherapy dosimetry, Radiation Oncology , 13 (2018) 121.
- [5] Arce P., Bolst D., Bordage M.C., Brown J.M.C., Cirrone P., Cortés-Giraldo M.A., Cutajar D., Cuttone G., Desorgher L., Dondero P., Dotti A., Faddegon B., Fedon C., Guatelli S., Incerti S., Ivanchenko V., Konstantinov D., Kyriakou I., Latyshev G., Le A., Mancini-Terracciano C., Maire M., Mantero A., Novak M., Omachi C., Pandola L., Perales A., Perrot Y., Petringa G., Quesada J.M., Ramos-Méndez J., Romano F., Rosenfeld A.B., Sarmiento L.G., Sakata D., Sasaki T., Sechopoulos I., Simpson E.C., Toshito T., Wright D.H., Report on G4-Med, a Geant4 benchmarking system for medical physics applications developed by the Geant4 Medical Simulation Benchmarking Group, Medical Physics, 48 (1) (2021) 19-56.
- [6] Amako K, On behalf of the Geant4 Collaboration, Nuclear Instruments and Methods in Physics Research, 453 (2000) 455-460.
- [7] Karaca M., Chemoradiotherapy in nasopharyngeal cancer, master thesis, Ankara university, School of Medicine Department of Radiation Oncology, (2008).
- [8] GATE Documentation, OpenGATE Collaboration, Available at:https://readthedocs.org/projects/gate demo/downloads/pdf/readthedocs/ Retrieved april 19,2022.
Details
Primary Language
English
Subjects
Classical Physics (Other)
Journal Section
Research Article
Publication Date
December 27, 2022
Submission Date
September 3, 2022
Acceptance Date
November 11, 2022
Published in Issue
Year 2022 Volume: 43 Number: 4
APA
Erkal, D., & Kuday, S. (2022). Carbon Radiotheraphy For Head and Neck Cancer: Dosimetric Comparison with Photon Plans. Cumhuriyet Science Journal, 43(4), 746-751. https://doi.org/10.17776/csj.1170486