In this study, a series of taurinamide derivatives 1–18 were assessed for their in vitro antimicrobial activity. Enterococcus faecalis, which is the third most commonly isolated nosocomial pathogen among hospital infections, was found to be more susceptible to the tested compounds than other pathogens. Two of the tested compounds, 1 and 18, showed promising activity against E. faecalis, with minimal inhibitory concentrations (MICs) of 128 and 64 µg/mL, respectively. On the other hand, compound 3 was distinguished from other compounds by its better activity against G(−) Escherichia coli bacteria, with a MIC of 512 μg/mL. None of the compounds displayed better activity than the standard drugs Ciprofloxacin and Fluconazole.
Taurine derivatives Antimicrobial activity Broth microdilution method.
The Scientific and Technological Research Council of Turkey
SBAG-118S667
The authors gratefully acknowledge The Scientific and Technological Research Council of Turkey [TÜBİTAK; Project number: SBAG-118S667] for financial assistance.
SBAG-118S667
Birincil Dil | İngilizce |
---|---|
Konular | Eczacılık ve İlaç Bilimleri |
Bölüm | Natural Sciences |
Yazarlar | |
Proje Numarası | SBAG-118S667 |
Yayımlanma Tarihi | 29 Aralık 2021 |
Gönderilme Tarihi | 1 Eylül 2021 |
Kabul Tarihi | 30 Kasım 2021 |
Yayımlandığı Sayı | Yıl 2021Cilt: 42 Sayı: 4 |