In vitro cytotoxic activity of Tarantula cubensis alcoholic extract on different human cell lines

Çisil Çamlı Pulat

doi:10.17776/csj.859132

EN

In vitro cytotoxic activity of Tarantula cubensis alcoholic extract on different human cell lines

Abstract

Spider venoms are known to have great potential for their antimicrobial, antifungal, and antitumor activities due to their rich peptide content. Tarantula cubensis alcoholic extract Theranekron® is a homeopathic remedy and it is frequently used in veterinary treatments. Specifically, the anti-inflammatory, antitumor and wound healing effects of Theranekron® provide a wide range of use in animal treatments. More importantly, it can reduce the growth rate of canine mammary tumors. This effect shows that Theranekron® can be a potential candidate for cancer treatment. In this study, the cytotoxic effect of Theranekron® was evaluated in four different human cancer cell lines and one non-cancerous human cell line. It was aimed to provide a foundation for further studies by conducting an in vitro screening for the cytotoxic effect of Theranekron®. Results showed that Theranekron® has a high cytotoxic effect on human breast cancer cell lines. On the other hand, the rate of cytotoxicity was found to be relatively lower on human small cell lung cancer, glioblastoma and human prostate cancer cell lines as compared to breast cancer cells. These results indicated that T. cubensis alcoholic extract might be utilized as an anticancer bio-therapeutic and should be further examined for its potential.

Keywords

Thanks

The experiments in this paper were partially performed at Manisa Celal Bayar University (Turkey) - Applied Science and Research Center (DEFAM). Theranekron D6 solution used for the experiments was accessed courtesy of Veterinary Physician Bora Benli.

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Details

Primary Language

English

Subjects

Structural Biology

Journal Section

Research Article

Authors

Çisil Çamlı Pulat ^*
0000-0002-9641-7219
Türkiye

Publication Date

June 30, 2021

Submission Date

January 12, 2021

Acceptance Date

June 15, 2021

Published in Issue

Year 1970 Volume: 42 Number: 2

DOI

https://doi.org/10.17776/csj.859132

IZ

https://izlik.org/JA68BW56HL

Cite

RIS / Bibtex

APA

Çamlı Pulat, Ç. (2021). In vitro cytotoxic activity of Tarantula cubensis alcoholic extract on different human cell lines. Cumhuriyet Science Journal, 42(2), 252-259. https://doi.org/10.17776/csj.859132