Curcumin-Loaded Bio-Based Electrospun Polyurethane Scaffolds

Nesrin Horzum Polat; Nehir Arık Kınalı

doi:10.17776/csj.505746

EN TR

Curcumin-Loaded Bio-Based Electrospun Polyurethane Scaffolds

Abstract

Polymeric electrospun fibers present well-design scaffolds for wound healing applications. Here, the fabrication of biobased polyurethane (PU) blend fibers containing curcumin (Cur) was reported. Not only polymer concentration but also curcumin concentration affects the morphology, diameter, and contact angle values of the fibers. Morphological investigations revealed that the diameter and hydrophilicity of the PU fibers increased upon addition of curcumin. Effect of process parameters (applied voltage, flow rate, and tip-to-collector distance) on the average diameter and the hydrophilicity of the PU and PU/Cur fibers were examined. Optimum conditions to obtain uniform and bead-free PU/Cur fibers were determined as 12.5 kV, 1 mL/h, and 17 cm. This study demonstrates that the electrospinning process provides a simple way of obtaining bioactive agent loaded fibrous scaffolds, as well as contributing to a better understanding of the effect of process variables in the fabrication of PU/Cur blend fibers for wound healing applications.

Keywords

bio-based polyurethane,curcumin,electrospinning,fibers,Biomaterials,wound healing

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Details

Primary Language

English

Subjects

-

Journal Section

Research Article

Authors

Nesrin Horzum Polat ^*
0000-0002-2782-0581
Türkiye

Nehir Arık Kınalı
0000-0002-6724-9463
Türkiye

Publication Date

March 22, 2019

Submission Date

December 31, 2018

Acceptance Date

February 21, 2019

Published in Issue

Year 1970 Volume: 40 Number: 1

DOI

https://doi.org/10.17776/csj.505746

IZ

https://izlik.org/JA78MT24UX

Cite

RIS / Bibtex

APA

Horzum Polat, N., & Arık Kınalı, N. (2019). Curcumin-Loaded Bio-Based Electrospun Polyurethane Scaffolds. Cumhuriyet Science Journal, 40(1), 125-135. https://doi.org/10.17776/csj.505746