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The Effects of Oxytocin and Oxytocin Receptor Antagonist Atosiban on the Carbonic Anhydrase and Acetylcholinesterase Enzymes from Lung Tissues of Rats

Yıl 2017, Cilt: 38 Sayı: 3, 450 - 460, 30.09.2017

Ümit M. Koçyiğit

https://doi.org/10.17776/csj.340483
Cited By: 6

Öz

The purpose
of our studies is to assist in fully understanding the role of oxytocin in the
live metabolism by examining the effects of oxytocin, oxytocin receptor antagonist
atosiban, and oxytocin-atosiban chemicals injected to the rats on activities of
carbonic anhydrase (CA) and acetylcholinesterase (AChE) enzymes in the lung
tissue of the rats. For this purpose, 4 different groups each of
which contains 6 rats formed. (Control group, oxytocin administered group,
atosiban administered group, and both oxytocin and atosiban administered
group). The rats were necropsied after an hour from the injection of chemicals
into the rats intraperitoneally. The lung tissues of the rats were extracted.
Carbonic anhydrase and acetylcholinesterase enzymes activities were measured
for the tissues.  All the experimental
results were provided as mean ± SD (mean
standard deviation). Because of the data was
compatible with the normal range, it was tested via variance analysis (ANOVA)
and then, significance was determined by the Tukey test. Statistical
significance was identified to be p <0.05.



Accordingly, it was observed that there was neither a decrease of
enzyme activities in oxytocin and atosiban administered groups, nor a
significant change of enzyme activities in both oxytocin and atosiban
administered group. Also, we observed that oxytocin reduced carbonic
anhydrase enzyme activity as a systemic effect. We think that this result may
contribute to remedy of lung related diseases progressing with oxygen and
carbon dioxide transport disorders. 

Anahtar Kelimeler

Carbonic Anhydrase Oxytocin Atosiban enzyme activity rat

Kaynakça

  • [1] Kelly, J., & Swanson, L.W. (1980). Additional forebrain regions projecting to the posterior pituitary: preoptic region, bed nucleus of the Stria terminalis, and Zona incerta. Brain research, 197(1), 1-9.
  • [2] Arletti, R., Benelli, A., & Bertolini, A. (1989). Influence of oxytocin on feeding behavior in the rat. Peptides, 10(1), 89-93.
  • [3] Sanu, O., & Lamont, R. F. (2010). Critical appraisal and clinical utility of atosiban in the management of preterm labor. Therapeutics and Clinical Risk Management, 6, 191.
  • [4] Berg, J.M.,Tymoczko, J.L., Stryer, L. (2014). Biyokimya. Palme Yayıncılık.241-247p,
  • [5] Gocer, H., Topal, F., Topal, M., Küçük, M., Teke, D., Gülçin, İ., ... & Supuran, C. T. (2016). Acetylcholinesterase and carbonic anhydrase isoenzymes I and II inhibition profiles of taxifolin. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(3), 441-447.
  • [6] Kocyigit, U. M., Aslan, O. N., Gulcin, I., Temel, Y., & Ceylan, M. (2016). Synthesis and carbonic anhydrase inhibition of novel 2-(4-(aryl)thiazole-2-yl)-3a,4,7,7a-tetrahydro-1h-4,7-methanoisoindole-1,3(2h)-dione derivatives. Archiv der Pharmazie, 349(12), 955-963.
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  • [8] Kucukoglu, K., Oral, F., Aydin, T., Yamali, C., Algul, O., Sakagami, H., ... & Gul, H. I. (2016). Synthesis, cytotoxicity and carbonic anhydrase inhibitory activities of new pyrazolines. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(S4), 20-24.
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  • [13] Özbey, F., Taslimi, P., Gülçin, İ., Maraş, A., Göksu, S., & Supuran, C. T. (2016). Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(S2), 79-85.
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  • [16] Taslimi, P., Sujayev, A., Mamedova, S., Kalın, P., Gulçin, İ., Sadeghian, N., ... & Mamedov, S. (2017). Synthesis and bioactivity of several new hetaryl sulfonamides. Journal of Enzyme Inhibition and Medicinal Chemistry, 32(1), 137-145.
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  • [19] Garibov, E., Taslimi, P., Sujayev, A., Bingol, Z., Çetinkaya, S., Gulçin, İ., ... & Supuran, C. T. (2016). Synthesis of 4, 5-disubstituted-2-thioxo-1, 2, 3, 4-tetrahydropyrimidines and investigation of their acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase I/II inhibitory and antioxidant activities. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(sup3), 1-9.
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Sıçanların Akciğer Dokusunda Oksitosin ve Oksitosin Reseptör Antagonisti Atosiban’ın Karbonik Anhidraz ve Asetilkolinesteraz Enzim Aktiviteleri Üzerine Etkileri

Yıl 2017, Cilt: 38 Sayı: 3, 450 - 460, 30.09.2017

Ümit M. Koçyiğit

https://doi.org/10.17776/csj.340483
Cited By: 6

Öz

Çalışmamızda,
sıçanlara enjekte edilen oksitosin ve oksitosin reseptör antagonisti olan atosibanın, sıçan akciğer dokusunda
karbonik anhidraz (CA) ve asetilkolinesteraz (AChE) enzim aktiviteleri üzerine
etkilerinin incelenerek, oksitosinin canlı metabolizmadaki rolünün tam olarak
anlaşılmasına yardımcı olmak amaçlanmıştır. Bu amaçla, her biri 6 adet sıçandan oluşan 4 farklı grup oluşturuldu.  (Kontrol grubu, oksitosin verilen grup,
atosiban verilen grup ve oksitosin ile atosibanın birlikte verildiği grup). Sıçanlara kimyasallar intraperitoneal olarak
enjekte edildikten bir saat sonra sıçanlar nekropsiye alındı. Sıçanların
akciğer dokuları çıkarıldı. Bu dokular için CA ve AChE aktiviteleri ölçüldü. Tüm deneysel sonuçlar ortalama±SH
(ortalamanın standart hatası) olarak ifade edildi. Veriler normal dağılıma
uygunluk gösterdiği için varyans analizi (ANOVA) ile test edildi ve daha sonra
anlamlılık Tukey test ile belirlendi. İstatistiksel anlamlılık p<0.05
düzeyinde tanımlandı. Buna göre, oksitosin ve atosiban verilen gruplarda enzim
aktivelerinde azalma, oksitosin ile atosibanın birlikte verildiği gruptaki
enzim aktivelerinde ise anlamlı bir değişiklik olmadığı görüldü.Ayrıca Oksitosinin sistemik bir etki olarak CA enzim aktivitesini azalttığını
gözlemledik. Bu sonucun akciğerle alakalı olan akciğer oksijen karbondioksit
taşınmasında bozuklukla seyreden hastalıklara katkısı olabileceğini
düşünmekteyiz.

Anahtar Kelimeler

Karbonik Anhidraz (CA) Oksitosin Atosiban enzim aktivite rat

Kaynakça

  • [1] Kelly, J., & Swanson, L.W. (1980). Additional forebrain regions projecting to the posterior pituitary: preoptic region, bed nucleus of the Stria terminalis, and Zona incerta. Brain research, 197(1), 1-9.
  • [2] Arletti, R., Benelli, A., & Bertolini, A. (1989). Influence of oxytocin on feeding behavior in the rat. Peptides, 10(1), 89-93.
  • [3] Sanu, O., & Lamont, R. F. (2010). Critical appraisal and clinical utility of atosiban in the management of preterm labor. Therapeutics and Clinical Risk Management, 6, 191.
  • [4] Berg, J.M.,Tymoczko, J.L., Stryer, L. (2014). Biyokimya. Palme Yayıncılık.241-247p,
  • [5] Gocer, H., Topal, F., Topal, M., Küçük, M., Teke, D., Gülçin, İ., ... & Supuran, C. T. (2016). Acetylcholinesterase and carbonic anhydrase isoenzymes I and II inhibition profiles of taxifolin. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(3), 441-447.
  • [6] Kocyigit, U. M., Aslan, O. N., Gulcin, I., Temel, Y., & Ceylan, M. (2016). Synthesis and carbonic anhydrase inhibition of novel 2-(4-(aryl)thiazole-2-yl)-3a,4,7,7a-tetrahydro-1h-4,7-methanoisoindole-1,3(2h)-dione derivatives. Archiv der Pharmazie, 349(12), 955-963.
  • [7] Gul, H. I., Mete, E., Taslimi, P., Gulcin, I., & Supuran, C. T. (2017). Synthesis, carbonic anhydrase I and II inhibition studies of the 1, 3, 5-trisubstituted-pyrazolines. Journal of Enzyme Inhibition And Medicinal Chemistry, 32(1), 189-192.
  • [8] Kucukoglu, K., Oral, F., Aydin, T., Yamali, C., Algul, O., Sakagami, H., ... & Gul, H. I. (2016). Synthesis, cytotoxicity and carbonic anhydrase inhibitory activities of new pyrazolines. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(S4), 20-24.
  • [9] Bhatt, A., Mahon, B. P., Cruzeiro, V. W. D., Cornelio, B., Laronze Cochard, M., Ceruso, M., & Roitberg, A. (2017). Structure–activity relationships of benzenesulfonamide based inhibitors towards carbonic anhydrase isoform specificity. Chembiochem, 18(2), 213-222.
  • [10] Akıncıoğlu, A., Topal, M., Gulcin, I., & Göksu, S. (2014). Novel sulphamides and sulphonamides incorporating the tetralin scaffold as carbonic anhydrase and acetylcholine esterase inhibitors. Archiv der Pharmazie, 347(1), 68-76.
  • [11] Göçer, H., Akincioğlu, A., Göksu, S., Gülçin, İ., & Supuran, C. T. (2015). Carbonic anhydrase and acetylcholine esterase inhibitory effects of carbamates and sulfamoylcarbamates. Journal of Enzyme Inhibition and Medicinal Chemistry, 30(2), 316-320.
  • [12] Polat Köse, L., Gülçin, İ., Gören, A.C., Namiesnik, J., Martinez-Ayala, A. L., & Gorinstein, S. (2015). LC–MS/MS analysis, antioxidant and anticholinergic properties of galanga (Alpinia officinarum Hance) rhizomes. Industrial Crops and Products, 74, 712-721.
  • [13] Özbey, F., Taslimi, P., Gülçin, İ., Maraş, A., Göksu, S., & Supuran, C. T. (2016). Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(S2), 79-85.
  • [14] Taslimi, P., Gulcin, I., Ozgeris, B., Goksu, S., Tumer, F., Alwasel, S. H., & Supuran, C. T. (2016). The human carbonic anhydrase isoenzymes I and II (hCA I and II) inhibition effects of trimethoxyindane derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(1), 152-157.
  • [15] Taslimi, P., Osmanova, S., Gulçin, İ., Sardarova, S., Farzaliyev, V., Sujayev, A., ... & Kufrevioglu, O. I. (2017). Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base. Journal of Biochemical and Molecular Toxicology, DOI: 10.1002/jbt.21931.
  • [16] Taslimi, P., Sujayev, A., Mamedova, S., Kalın, P., Gulçin, İ., Sadeghian, N., ... & Mamedov, S. (2017). Synthesis and bioactivity of several new hetaryl sulfonamides. Journal of Enzyme Inhibition and Medicinal Chemistry, 32(1), 137-145.
  • [17] Gül, H. I., Demirtas, A., Ucar, G., Taslimi, P., Gulcin, I. (2017). Synthesis of Mannich bases by two different methods and evaluation of their acetylcholine esterase and carbonic anhydrase inhibitory activities. Letters in Drug Design and Discovery, 14(5), 573-580.
  • [18] Aksu, K., Özgeriş, B., Taslimi, P., Naderi, A., Gülçin, İ., & Göksu, S. (2016). Antioxidant activity, acetylcholinesterase, and carbonic anhydrase ınhibitory properties of novel ureas derived from phenethylamines. Archiv der Pharmazie, 349(12), 944-954.
  • [19] Garibov, E., Taslimi, P., Sujayev, A., Bingol, Z., Çetinkaya, S., Gulçin, İ., ... & Supuran, C. T. (2016). Synthesis of 4, 5-disubstituted-2-thioxo-1, 2, 3, 4-tetrahydropyrimidines and investigation of their acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase I/II inhibitory and antioxidant activities. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(sup3), 1-9.
  • [20] Özbey, F., Taslimi, P., Gülçin, İ., Maraş, A., Göksu, S., & Supuran, C. T. (2016). Synthesis of diaryl ethers with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(S2), 79-85.
  • [21] Turan, B., Şendil, K., Şengül, E., Gültekin, M. S., Taslimi, P., Gulçin, İ., & Supuran, C. T. (2016). The synthesis of some β-lactams and investigation of their metal-chelating activity, carbonic anhydrase and acetylcholinesterase inhibition profiles. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(S1), 79-88.
  • [22] Gul, H. I., Tugrak, M., Sakagami, H., Taslimi, P., Gulcin, I., & Supuran, C. T. (2016). Synthesis and bioactivity studies on new 4-(3-(4-Substitutedphenyl)-3a, 4-dihydro-3 H-indeno [1,2-c] pyrazol-2-yl) benzenesulfonamides Journal of Enzyme Inhibition and Medicinal Chemistry, 31(6), 1619-1624.
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  • [32] Aksu, K., Özgeriş, B., Taslimi, P., Naderi, A., Gülçin, İ., & Göksu, S. (2016). Antioxidant Activity, Acetylcholinesterase, and Carbonic Anhydrase Inhibitory Properties of Novel Ureas Derived from Phenethylamines. Archiv der Pharmazie, 349(12), 944-954.
  • [33] Gul, H. I., Tugrak, M., Sakagami, H., Taslimi, P., Gulcin, I., & Supuran, C. T. (2016). Synthesis and bioactivity studies on new 4-(3-(4-Substitutedphenyl)-3a, 4-dihydro-3 H-indeno [1, 2-c] pyrazol-2-yl) benzenesulfonamides. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(6), 1619-1624.
  • [34] Göçer, H., Akıncıoğlu, A., Öztaşkın, N., Göksu, S., & Gülçin, İ. (2013). Synthesis, antioxidant, and antiacetylcholinesterase activities of sulfonamide derivatives of dopamine-related compounds. Archiv der Pharmazie, 346(11), 783-792.
  • [35] Akbaba, Y., Bastem, E., Topal, F., Gülçin, İ., Maraş, A., & Göksu, S. (2014). synthesis and carbonic anhydrase inhibitory effects of novel sulfamides derived from 1-aminoindanes and anilines. Archiv der Pharmazie, 347(12), 950-957.
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  • [37] Sujayev, A., Garibov, E., Taslimi, P., Gulçin, İ., Gojayeva, S., Farzaliyev, V., ... & Supuran, C. T. (2016). Synthesis of some tetrahydropyrimidine-5-carboxylates, determination of their metal chelating effects and inhibition profiles against acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase. Journal of Enzyme Inhibition and Medicinal Chemistry, 31(6), 1531-1539.
  • [38] H. I. Gül, K. Kucukoglu, C. Yamali, S. Bilginer, H. Yuca, I. Ozturk, P.Taslimi, I. Gülçin, C. T. Supuran, (2016). Synthesis of 4-(2-substitutedhydrazinyl)benzenesulfonamides and their carbonic anhydrase inhibitory effects. Journal of Enzyme Inhibition and Medicinal Chemistry, 31,568-573.
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  • [47] Kocyigit UM, Taskıran A, Taslimi P,Yokus A, Gulcın I, (2017). Inhibitory effects of oxytocin and oxytocin receptor antagonist atosiban on the activities of carbonic anhydrase and acetylcholinesterase enzymes in the liver and kidney tissues of rats. Journal of Biochemical and Molecular Toxicology, DOI: 10.1002/jbt.21972.
  • [48] Pullan, L.M. and Noltmann, E.A., (1985). Purification and properties of pig muscle carbonic anhydrase III. Biochimica et Biophysica Acta, 839, 147-54.
  • [49] Wilbur, K.M. and Anderson, N.G., (1948). Electrometric and colorimetric determination of carbonic anhydrase. Journal of Biological Chemistry, 176, 147-154.
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Toplam 54 adet kaynakça vardır.

Ayrıntılar

Bölüm Makaleler
Yazarlar

Ümit M. Koçyiğit

Yayımlanma Tarihi 30 Eylül 2017
Gönderilme Tarihi 9 Haziran 2017
Kabul Tarihi 28 Ağustos 2017
Yayımlandığı Sayı Yıl 2017Cilt: 38 Sayı: 3

Kaynak Göster

APA Koçyiğit, Ü. M. (2017). The Effects of Oxytocin and Oxytocin Receptor Antagonist Atosiban on the Carbonic Anhydrase and Acetylcholinesterase Enzymes from Lung Tissues of Rats. Cumhuriyet Science Journal, 38(3), 450-460. https://doi.org/10.17776/csj.340483

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