Kötü obstetrik öyküsü ve deri hastalıkları olan kadınlarda anti-parietal hücre antikor pozitifliği: gebelik öncesi danışmanlığın önemi
Öz
Amaç: BU çalışmanın amacı kötü obstetrik öyküsü ve deri hastalıkları olan kadınlarda anti-parietal hücre antikor (APCA) pozitifliğinin anlamını göstermektir.
Gereç ve Yöntem: Bu retrospektif kohort, deri hastalıkları ve kötü obstetrik geçmişi olan 63 kadından oluşuyordu. Hastalar kontrol (sadece deri hastalıkları olan kadınlar, n=50) ve çalışma grubu (deri hastalıkları ve APCA pozitifliği olan kadınlar, n=13) olarak gruplandırılmıştır. Çalışma ve kontrol grubu demografik bulgular, BOI ve plasentaya bağlı obstetrik komplikasyonlarla ilişkili risk faktörleri açısından karşılaştırıldı.
Bulgular: APCA (+) ve APCA (–) grupları; yaş, gravida, parite, BOI ve düşük sayısı gibi demografik bulgular açısından istatistiksel olarak anlamlı farklılık göstermedi. APCA (+) vakaların %69,2'sinin (9/13) iki veya daha fazla deri hastalığına sahip olduğunu, ancak bu oranın APCA (-) olanlarda %34 bulunduğunu gösterdik. APCA (+) ve APCA (–) grupları arasında tekli ve çoklu deri hastalığı varlığı açısından istatistiksel olarak anlamlı fark vardı. APCA (+) ve APCA (-) hastalar arasında obstetrik komplikasyonlarla ilişkili risk faktörlerinin (bağışıklık sistemi sorunları, MTHFR polimorfizmleri, kalıtsal trombofili ve diyabetes mellitus tip-2 gibi) varlığı açısından istatistiksel olarak anlamlı bir farklılık gösteremedik.
Sonuç: Obstetrik komplikasyonlar için risk faktörü olan APCA pozitifliğinin, gebelik öncesi danışma sırasında belirlenmesi, kötü obstetrik öykü ve dermatolojik sorunları olan hastalarda çoklu deri hastalıklarının önceden belirlenmesinde önemli rol oynayabilir.
Anahtar Kelimeler
Anti-Parietal Antikor Cilt Bozukluğu Kötü Obstetrik Öykü Gebelik öncesi danışmanlık
Kaynakça
- Beksac B, Donmez HG, Cagan M, Unal C, Fadiloglu E, Beksac MS. Acrochordons and autoimmunity: Significance of preconceptional counseling. Hum Antibodies. 2020;28:335-9.
- Akpinar F, Dervis E. Association between acrochordons and the components of metabolic syndrome. Eur J Dermatol. 2012;22:106-10.
- Beksac B, Donmez HG. Association of bacterial vaginosis and skin disorders in patients with autoimmune antibody positivity. Gynecol Obstet Reprod Med. 2021;27:150-3.
- Hu Y, Zhu Y, Lian N, Chen M, Bartke A, Yuan R. Metabolic syndrome and skin diseases. Front Endocrinol (Lausanne). 2019;10:788.
- Rusak E, Chobot A, Krzywicka A, Wenzlau J. Anti-parietal cell antibodies- diagnostic significance. Adv Med Sci. 2016;61:175-9.
- Fadiloglu E, Unal C, Beksac MS. Management and the pregnancy outcomes of patients positive for anti-parietal cell antibody. Hum Antibodies. 2019;27:111-6.
- Ünal C, Fadiloglu E, Beksac MS. Pregnancy outcomes of the patients with anti-smooth muscle antibody positivity. Hum Antibodies. 2019;27:167-70.
- Tanacan A, Beksac MS, Orgul G, Duru S, Sener B, Karaagaoglu E. Impact of extractable nuclear antigen, anti-double stranded DNA, antiphospholipid antibody, and anticardiolipin antibody positivity on obstetrical complications and pregnancy outcomes. Hum Antibodies. 2019;27:135-41.
- Mumusoglu S, Beksac MS, Ekiz A, Ozdemir P, Hascelik G. Does the presence of autoantibodies without autoimmune diseases and hereditary thrombophilia have an effect on recurrent pregnancy loss? J Matern Fetal Neonatal Med. 2016;29:2352-7.
- Cagan M, Okuducu U, Donmez HG, Beksac MS. Singleton pregnancy losses before gestational week 22 among patients with autoimmune disorders and Methylenetetrahydrofolate reductase polymorphisms. Hum Antibodies. 2022;30:59-65.
- Beksac MS, Tanacan A, Ozten G, Cakar AN. Low-dose low-molecular-weight heparin prophylaxis against obstetrical complications in pregnancies with metabolic and immunological disorder-associated placental inflammation. J Matern Fetal Neonatal Med. 2022;35:1546-53.
- Beksac MS, Donmez HG. Association of increased C-Reactive Protein and hypocomplementemia with risk factors for thrombosis in women who have susceptibility for poor gestational outcome; importance of preconceptional counseling. Hum Antibodies. 2021;29:249-54.
- Beksac MS, Donmez HG. Impact of hydroxychloroquine on the gestational outcomes of pregnant women with immune system problems that necessitate the use of the drug. J Obstet Gynaecol Res. 2021;47:570-5.
- Beksac B, Donmez HG, Beksac MS. Association of high levels of C-reactive protein with skin disorders in women having poor obstetric history. Obstet Ginecol (Bucur). 2021;69:58-61.
- Lorini R, Orecchia G, Martinetti M, Dugoujon JM, Cuccia M. Autoimmunity in vitiligo: relationship with HLA, Gm and Km polymorphisms. Autoimmunity. 1992;11:255-60.
- Kumar B, Sharma VK, Sehgal S. Antismooth muscle and antiparietal cell antibodies in Indians with alopecia areata. Int J Dermatol. 1995;34:542-5.
- Beksac B, Donmez HG, Beksac MS. Poor obstetric history, skin disorders and type-2 diabetes mellitus. Obstet Ginecol (Bucur). 2022;70:20-3
Anti-parietal cell antibody positivity in women with poor obstetric history and skin disorders: significance of preconception counseling
Öz
Purpose: The aim of this study was vto demonstrate the impact of anti-parietal cell antibody (APCA) positivity in women with poor obstetric history and skin disorders.
Materials and Methods: This retrospective cohort consisted of 63 women having skin disorders and poor obstetric history. Patients were grouped into the control (women with skin disorders only, n=50) and study groups (women with skin disorders and APCA positivity, n=13). The study groups were compared in terms of demographic findings, BOI, and risk factors for placenta-related obstetric complications.
Results: APCA (+) and APCA (–) groups showed no statistically significant difference in terms of demographic findings such as age, gravidity, parity, BOI, and the number of miscarriages.. We have demonstrated that 69.2% (9/13) of the APCA (+) cases have two or more skin diseases, while 34% of APCA (-) women have multiple skin diseases. There was a statistically significant difference between APCA (+) and APCA (–) groups in terms of the presence of single or multiple skin diseases (p=0.029). We could not demonstrate a statistically significant difference between APCA (+) and APCA (–) patients in terms of the presence of risk factors for obstetric complications such as immune system problems, MTHFR polymorphisms, hereditary thrombophilia, and diabetes mellitus type-2.
Conclusion: APCA positivity which is a risk factor for obstetric complications might be a good indicator used to identify susceptibility to multiple skin disorders during preconception counseling.
Anahtar Kelimeler
Anti-parietal antibody skin disorders poor obstetric history preconception counseling
Kaynakça
- Beksac B, Donmez HG, Cagan M, Unal C, Fadiloglu E, Beksac MS. Acrochordons and autoimmunity: Significance of preconceptional counseling. Hum Antibodies. 2020;28:335-9.
- Akpinar F, Dervis E. Association between acrochordons and the components of metabolic syndrome. Eur J Dermatol. 2012;22:106-10.
- Beksac B, Donmez HG. Association of bacterial vaginosis and skin disorders in patients with autoimmune antibody positivity. Gynecol Obstet Reprod Med. 2021;27:150-3.
- Hu Y, Zhu Y, Lian N, Chen M, Bartke A, Yuan R. Metabolic syndrome and skin diseases. Front Endocrinol (Lausanne). 2019;10:788.
- Rusak E, Chobot A, Krzywicka A, Wenzlau J. Anti-parietal cell antibodies- diagnostic significance. Adv Med Sci. 2016;61:175-9.
- Fadiloglu E, Unal C, Beksac MS. Management and the pregnancy outcomes of patients positive for anti-parietal cell antibody. Hum Antibodies. 2019;27:111-6.
- Ünal C, Fadiloglu E, Beksac MS. Pregnancy outcomes of the patients with anti-smooth muscle antibody positivity. Hum Antibodies. 2019;27:167-70.
- Tanacan A, Beksac MS, Orgul G, Duru S, Sener B, Karaagaoglu E. Impact of extractable nuclear antigen, anti-double stranded DNA, antiphospholipid antibody, and anticardiolipin antibody positivity on obstetrical complications and pregnancy outcomes. Hum Antibodies. 2019;27:135-41.
- Mumusoglu S, Beksac MS, Ekiz A, Ozdemir P, Hascelik G. Does the presence of autoantibodies without autoimmune diseases and hereditary thrombophilia have an effect on recurrent pregnancy loss? J Matern Fetal Neonatal Med. 2016;29:2352-7.
- Cagan M, Okuducu U, Donmez HG, Beksac MS. Singleton pregnancy losses before gestational week 22 among patients with autoimmune disorders and Methylenetetrahydrofolate reductase polymorphisms. Hum Antibodies. 2022;30:59-65.
- Beksac MS, Tanacan A, Ozten G, Cakar AN. Low-dose low-molecular-weight heparin prophylaxis against obstetrical complications in pregnancies with metabolic and immunological disorder-associated placental inflammation. J Matern Fetal Neonatal Med. 2022;35:1546-53.
- Beksac MS, Donmez HG. Association of increased C-Reactive Protein and hypocomplementemia with risk factors for thrombosis in women who have susceptibility for poor gestational outcome; importance of preconceptional counseling. Hum Antibodies. 2021;29:249-54.
- Beksac MS, Donmez HG. Impact of hydroxychloroquine on the gestational outcomes of pregnant women with immune system problems that necessitate the use of the drug. J Obstet Gynaecol Res. 2021;47:570-5.
- Beksac B, Donmez HG, Beksac MS. Association of high levels of C-reactive protein with skin disorders in women having poor obstetric history. Obstet Ginecol (Bucur). 2021;69:58-61.
- Lorini R, Orecchia G, Martinetti M, Dugoujon JM, Cuccia M. Autoimmunity in vitiligo: relationship with HLA, Gm and Km polymorphisms. Autoimmunity. 1992;11:255-60.
- Kumar B, Sharma VK, Sehgal S. Antismooth muscle and antiparietal cell antibodies in Indians with alopecia areata. Int J Dermatol. 1995;34:542-5.
- Beksac B, Donmez HG, Beksac MS. Poor obstetric history, skin disorders and type-2 diabetes mellitus. Obstet Ginecol (Bucur). 2022;70:20-3
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Araştırma |
| Yazarlar | |
| Yayımlanma Tarihi | 31 Mart 2023 |
| Kabul Tarihi | 15 Mart 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 48 Sayı: 1 |
