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CT-DNA/BSA Binding Studies of Thiosemicarbazone-Derivated Zn(II) Complex

Yıl 2022, Cilt: 43 Sayı: 1, 45 - 52, 30.03.2022

Asuman Uçar Mükerrem Fındık Emine Akgemci

https://doi.org/10.17776/csj.1004338
Cited By: 1

Öz

Zn(II) complex of 2-hydroxy-5-methoxyacetophenone thiosemicarbazone { Zn(HMAT)2} was synthesized and characterized by 1H NMR, UV–Vis and FT-IR spectroscopies. Further, X-ray powder diffraction (XRD) analysis of Zn(HMAT)2 was carried out to point out the complexation. The binding affinities of Zn(HMAT)2 with calf thymus DNA (CT-DNA) have been studied by using fluorescence and absorption titration technics. In addition, bovine serum albumin (BSA) binding studies were recorded by fluorescence and UV–Vis spectroscopy. Zn(HMAT)2 is a strong binders of CT-DNA with binding constant (Kb) 3.65×107 M−1. The binding parameters KSV (for EB), Kq (for BSA) and Kb (for BSA) were determined as 8.2×107 M−1, 1.8×1014 M−1 s−1 and 2×107 M−1 respectively.

Anahtar Kelimeler

DNA Thiosemicarbazone Zn(II) complex Bovine serum albumin binding

Kaynakça

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Yıl 2022, Cilt: 43 Sayı: 1, 45 - 52, 30.03.2022

Asuman Uçar Mükerrem Fındık Emine Akgemci

https://doi.org/10.17776/csj.1004338
Cited By: 1

Öz

Kaynakça

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  • [2] Li V.S., Choi D., Wang Z., Jimenez L.S., Tang M.S., Kohn H., Role of the C-10 substituent in mitomycin C-1-DNA bonding, J. Am. Chem. Soc., 118 (10) (1996) 2326–2331.
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  • [5] Giannini F., Suss-Fink G., Furrer J., Efficient Oxidation of Cysteine and Glutathione Catalyzed by a Dinuclear Areneruthenium Trithiolato Anticancer Complex, Inorg. Chem., 50 (21) (2011) 10552-10554.
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  • [12] Mathews N.A., Kurup M.R.P., In vitro biomolecular interaction studies and cytotoxic activities of copper(II) and zinc(II) complexes bearing ONS donor thiosemicarbazones, Appl. Organomet. Chem., 35(1) (2020) 6056.
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  • [14] Haribabu J., Priyarega S., Bhuvanesh N.S.P., Karvembu R., Synthesis and molecular structure of the zinc(II) complex bearing an N, S donor ligand, J. Struct. Chem., 61(1) (2020) 66-72.
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  • [16] Zareia L., Asadi Z., Samolova E., Dusek M., Amirghofran Z., Pyrazolate as bridging ligand in stabilization of self-assemble Cu(II) Schiff base complexes: Synthesis, structural investigations, DNA/protein (BSA) binding and growth inhibitory effects on the MCF7, CT-26, MDA-MB-231 cell lines, Inorg. Chim. Acta, 509 (20201) 19674-119687.
  • [17] Ghosh K.S., Sen S., Sahoo B.K., Dasgupta S., A spectroscopic investigation into the interactions of 3′-O-carboxy esters of thymidine with bovine serum albumin, Biopolymers: Orig. Res. Biomol., 91 (9) (2009) 737–744.
  • [18] Ucar A., Findik M., Kuzu M., Pehlivanoglu S., Sayin U., Sayin Z., Akgemci E.G., Cytotoxic effects, microbiological analysis and inhibitory properties on carbonic anhydrase isozyme activities of 2 hydroxy 5 methoxyacetophenone thiosemicarbazone and its Cu(II), Co(II), Zn(II) and Mn(II) complexes, Res. Chem. Intermed., 47 (2021) 533-550.
  • [19] Akgemci E.G., Saf A.O., Tasdemir H.U., Türkkan E., Bingol H., Turan S.O., Akkiprik M., Spectrophotometric, voltammetric and cytotoxicity studies of 2-hydroxy-5-methoxyacetophenone thiosemicarbazone and its N(4)-substituted derivatives: A combined experimental–computational study, Spectrochim. Acta Part A Mol. Biomol. Spectrosc., 136 (2015) 719-725.
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  • [21] Santoro A., Vileno B., Palacios Ò., Díazd M.D.P., Riegel G., Gaiddon C., Krężel A., Faller P., Reactivity of Cu(II)-, Zn(II)- and Fe(II)- thiosemicarbazone complexes with glutathione and metallothionein: from stability to dissociation to transmetallation, Metallomics, 11 (2019) 994-1004.
  • [22] Cıkla I.K., Güveli S., Yavuz M., Demirci T.B., Ülküseven B., 5-Methyl-2-hydroxy-acetophenone-thiosemicarbazone and its nickel(II) complex: Crystallographic, spectroscopic (IR, NMR and UV) and DFT studies, Polyhedron, 105 (2016) 104-114.
  • [23] Sharma D., Jasinski J.P., Smolinski V.A., Kaur M., Paul K., Sharma R., Synthesis and structure of complexes (NiII, AgI) of substituted benzaldehyde thiosemicarbazones and antitubercular activity of NiII complex, Inorg. Chim. Acta, 499 (2020) 119187-119194.
  • [24] Konakanchi R., Haribabu J., Prashanth J., Nishtala V.B., Mallela R., Manchala S., Gandamalla D., Karvembu R., Reddy B.V., Yellu N.R., Kotha L.R., Synthesis, Structural, Biological Evaluation, Molecular Docking and DFT Studies of Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) Complexes bearing Heterocyclic Thiosemicarbazone ligand, Appl. Organomet. Chem., 32 (8) (2018) 4415.
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Toplam 55 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Natural Sciences
Yazarlar

Asuman Uçar 0000-0003-2674-3120

Mükerrem Fındık 0000-0002-9441-0814

Emine Akgemci 0000-0002-9744-1931

Yayımlanma Tarihi 30 Mart 2022
Gönderilme Tarihi 4 Ekim 2021
Kabul Tarihi 7 Şubat 2022
Yayımlandığı Sayı Yıl 2022Cilt: 43 Sayı: 1

Kaynak Göster

APA Uçar, A., Fındık, M., & Akgemci, E. (2022). CT-DNA/BSA Binding Studies of Thiosemicarbazone-Derivated Zn(II) Complex. Cumhuriyet Science Journal, 43(1), 45-52. https://doi.org/10.17776/csj.1004338

Cited By

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