N-Alkoxycarbonyl / carbamoylmethyl substituted 1H-imidazol-2-yliden-Pd (II) complexes (Cat-1-5) were used for the first time as catalysts in the Suzuki-Miyaura reaction between aryl bromides and arylboronic acids. All complexes screened were found to be excellent catalysts in the selected coupling between 4-bromobenzaldehyde and phenylboronic acid at room temperature. Cat-3 was shown to be the most efficient one and used for the optimisation of the reaction conditions and determining the substrate scope. The application of the optimised method provided a series of biaryls (3a-l) in excellent isolated yields. With these promising results the catalysts could be applied succesfully to some other classic cross-coupling reactions such as Sonogashira, Stille and Buchwald-Hartwig.
Suzuki coupling N-Heterocyclic Carbenes Pd(II)-N-Heterocyclic Carbene complexes
Prof. Dr. Nejdet Coşkun
N-Alkoxycarbonyl / carbamoylmethyl substituted 1H-imidazol-2-yliden-Pd (II) complexes (Cat-1-5) were used for the first time as catalysts in the Suzuki-Miyaura reaction between aryl bromides and arylboronic acids. All complexes screened were found to be excellent catalysts in the selected coupling between 4-bromobenzaldehyde and phenylboronic acid at room temperature. Cat-3 was shown to be the most efficient one and used for the optimisation of the reaction conditions and determining the substrate scope. The application of the optimised method provided a series of biaryls (3a-l) in excellent isolated yields. With these promising results the catalysts could be applied succesfully to some other classic cross-coupling reactions such as Sonogashira, Stille and Buchwald-Hartwig.
Pd(II)-NHC complexes Suzuki coupling N-heterocyclic Carbenes
Birincil Dil | İngilizce |
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Bölüm | Natural Sciences |
Yazarlar | |
Yayımlanma Tarihi | 29 Mart 2021 |
Gönderilme Tarihi | 10 Ekim 2020 |
Kabul Tarihi | 27 Ocak 2021 |
Yayımlandığı Sayı | Yıl 2021 |