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Naftokinon-Urazol Melezlerinin Antioksidan Etki Mekanizmaları Üzerine DFT Çalışması

Year 2018, , 734 - 744, 30.09.2018

Dilara Özbakır Işın

https://doi.org/10.17776/csj.454294
Cited By: 1

Abstract

Bu çalışmanın amacı, naftokinon-urazol melezlerinin antioksidan
aktivitelerinin teorik ve deneysel sonuçlar karşılaştırarak değerlendirilmesi
ve antioksidan etki mekanizmalarının araştırılmasıdır. Bu amaçla, incelenen
naftokinon-urazol melezleri ve iyonik formları için kuantum kimyasal
hesaplamalar B3LYP / 6-311 ++ G (d, p) düzeyinde hem gaz hem de su fazında
yapılmıştır. Antioksidan aktiviteleri üzerine suyun çözücü etkisi, aynı
hesaplama düzeyinde C-PCM yöntemi kullanılarak araştırıldı. Naftokinon-urazol
melezleri için antioksidan etki mekanizmaları, bazı fizikokimyasal parametreler
kullanılarak termodinamik olarak değerlendirildi.

Keywords

Antioksidan mekanizma naftokinon-urazol melezleri DFT HAT SET-PT SPLET

References

  • [1]. Mokini Z., Marcovecchio, M. L., & Chiarelli, F., Molecular pathology of oxidative stress in diabetic angiopathy: role of mitochondrial and cellular pathways, Diabetes Research and Clinical Practice, 87-3 (2010) 313-321.
  • [2]. Kamkar, A., Javan, A. J., Asadi, F., & Kamalinejad, M., The antioxidative effect of Iranian Mentha pulegium extracts and essential oil in sunflower oil, Food and Chemical Toxicology, 48-7 (2010) 1796-1800.
  • [3]. Kovacic, P., & Somanathan, R., Recent developments in the mechanism of anticancer agents based on electron transfer, reactive oxygen species and oxidative stress. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 11-7 (2011) 658-668.
  • [4]. Salustiano, E. J., Netto, C. D., Fernandes, R. F., da Silva, A. J., Bacelar, T. S., Castro, C. P., .. & Costa, P. R., Comparison of the cytotoxic effect of lapachol, α-lapachone and pentacyclic 1, 4-naphthoquinones on human leukemic cells, Investigational new drugs, 28-2 (2011) 139-144.
  • [5]. Gaikwad, P., Barik, A., Priyadarsini, K. I., & Rao, B. S. M., Antioxidant activities of phenols in different solvents using DPPH assay, Research on chemical intermediates, 36-9 (2011) 1065-1072.
  • [6]. Kuwahara, R., Hatate, H., Yuki, T., Murata, H., Tanaka, R., & Hama, Y., Antioxidant property of polyhydroxylated naphthoquinone pigments from shells of purple sea urchin Anthocidaris crassispina, LWT-Food Science and Technology, 42-7 (2009) 1296-1300.
  • [7]. Jacobson, C. R., A. D. Adamo, and C. E. Cosgrove. "US Patent, 3,663,564, 1972." Chem. Abstr. Vol. 76. 1972.
  • [8]. Wellington, K. W., Understanding cancer and the anticancer activities of naphthoquinones–a review. RSC Advances, 5-26 (2015) 20309-20338.
  • [9]. T. Jikihara, K. Matsuya, H. Ohta, S. Suzuki and O. Wakabayashi, US Pat. 4249934 A, 1981, Chem. Abstr., 95 (1981) 62219 y.
  • [10]. R. A. Izydore and I. H. Hall, US Pat. 4866058, 1990, Chem. Abstr.,112 (1990) 151876 x.
  • [11]. B. V. Bredow and H. Brechbuehler, Ger. Offen. 2343347 A1, Chem. Abstr., 80 (1974) 140210 s.
  • [12]. Saluja, P., Khurana, J. M., Nikhil, K., & Roy, P., Task-specific ionic liquid catalyzed synthesis of novel naphthoquinone–urazole hybrids and evaluation of their antioxidant and in vitro anticancer activity. RSC Advances, 4.65 (2014) 34594-34603.
  • [13]. Wright, J. S., Johnson, E. R., & DiLabio, G. A., Predicting the activity of phenolic antioxidants: theoretical method, analysis of substituent effects, and application to major families of antioxidants. Journal of the American Chemical Society, 123-6 (2001) 1173-1183.
  • [14]. Bartmess, J. E., Thermodynamics of the electron and the proton. The Journal of Physical Chemistry, 98-25 (1994) 6420-6424.
  • [15]. Klein, E., Rimarcik, J., & Lukes, V., DFT/B3LYP study of the O–H bond dissociation enthalpies and proton affinities of para-and meta-substituted phenols in water and benzene, Acta Chim. Slovaca, 2-2 (2009) 37-51.
  • [16]. Rimarčík, J., Lukeš, V., Klein, E., & Ilčin, M., Study of the solvent effect on the enthalpies of homolytic and heterolytic N–H bond cleavage in p-phenylenediamine and tetracyano-p-phenylenediamine, Journal of Molecular Structure: THEOCHEM, 952(1-3) (2010) 25-30.
  • [17]. Parker, V. D., Homolytic bond (HA) dissociation free energies in solution. Applications of the standard potential of the (H+/H. bul.) couple, Journal of the American Chemical Society, 114-19 (1992) 7458-7462.
  • [18]. Bizarro, M. M., Cabral, B. J. C., de Santos, R. M. B., & Simões, J. A. M., Substituent effects on the OH bond dissociation enthalpies in phenolic compounds: agreements and controversies, Pure and Applied Chemistry, 71-8 (1999) 1609-1610.
  • [19]. M.A. Robb, J.R. Cheeseman, M.J. Frisch, G.W. Trucks,H.B. Schlegel, G.E. Scuseria, M.A. Robb, J.R. Cheeseman, G. Scalmani, V. Barone, B. Mennucci, G.A. Petersson, H. Nakatsuji,M. Caricato, X. Li,H.p.Hratchian, A.F. Izmaylov, J. Bloino, G. Zheng, J.L. Sonnenberg, M. Hada, M. Ehara, K. Toyota, R. Fukuda, J.Hasegawa, M. Ishida, T. Nakajima, Y. Honda, O. Kitao, H. Nakai, T. Vreven, J.A.Montgomery, Jr., J.E. Peralta, F. Ogliaro,M. Bearpark, J.J. Heyd, E. Brothers, K.N. Kudin, V.N. Staroverov, R. Kobayashi, J. Normand, K. Raghavachari, A. Rendell,J.C. Burant, S.S. Iyengar, J.Tomasi, M. Cossi, N. Rega, J.M. Millam, M.Klene, J.E. Knox, J.B. Cross,V. Bakken, C. Adamo, J.Jaramillo, R. Gompert, R.E. Stratmann, O. Yazyev, A.J. Austin, R. Cammi, C. Pomelli, J.W.Ochterski, R.L. Martin,K. Morokuma, V.G. Zakrzewski, G.A. Voth, P. Salvador, J.J. Dannenberg, S. Dapprich, A.D. Daniels, O. Farkas, J.B. Foresman, J.V.Ortiz, J. Cioslowski, andD.J. Fox, Gaussian 09, Revision C.01 (Gaussian Inc.,Wallingford,CT, (2010).
  • [20]. Becke, A. D., Density‐functional thermochemistry. III. The role of exact exchange, The Journal of chemical physics, 98-7 (1993) 5648-5652.
  • [21]. Cances, E., Mennucci, B., & Tomasi, J., A new integral equation formalism for the polarizable continuum model: Theoretical background and applications to isotropic and anisotropic dielectrics. The Journal of chemical physics, 107-8 (1997) 3032-3041.
  • [22]. Özbakır Işın, D., Theoretical study on the investigation of antioxidant properties of some hydroxyanthraquinones, Molecular Physics, 114-24 (2016) 3578-3588.
  • [23]. Kabanda, M. M., Tran, V. T., Seema, K. M., Serobatse, K. R., Tsiepe, T. J., Tran, Q. T., & Ebenso, E. E., Conformational, electronic and antioxidant properties of lucidone, linderone and methyllinderone: DFT, QTAIM and NBO studies, Molecular Physics, 113-7 (1015) 683-697.
  • [24]. Cai, W., Chen, Y., Xie, L., Zhang, H., & Hou, C., Characterization and density functional theory study of the antioxidant activity of quercetin and its sugar-containing analogues, European Food Research and Technology, 238-1 (2014) 121-128.
  • [25]. Markovic, Zoran S., Slavko V. Mentus, and Jasmina M. Dimitrić Marković., Electrochemical and density functional theory study on the reactivity of fisetin and its radicals: implications on in vitro antioxidant activity, The journal of physical chemistry A 113-51 (2009) 14170-14179.
  • [26]. Leopoldini, M., Russo, N., & Toscano, M., Gas and liquid phase acidity of natural antioxidants, Journal of agricultural and food chemistry, 54-8 (2006) 3078-3085.
  • [27]. Marković, Z., Jeremić, S., Marković, J. D., Pirković, M. S., & Amić, D., Influence of structural characteristics of substituents on the antioxidant activity of some anthraquinone derivatives, Computational and Theoretical Chemistry, 1077 (2016) 25-31.

DFT Study on Antioxidant Action Mechanisms of Naphthoquinone-Urazole Hybrids

Year 2018, , 734 - 744, 30.09.2018

Dilara Özbakır Işın

https://doi.org/10.17776/csj.454294
Cited By: 1

Abstract

The aim of this study is on the evaluation of
the antioxidant activities of the investigated naphthoquinone-urazole hybrids
by comparing our theoretical results with experimental results and on the
elucidation the antioxidant action mechanisms. For this purpose, quantum
chemical calculations were performed at the B3LYP/6-311++G(d,p) level for the
investigated naphthoquinone-urazole hybrids and their ionic forms in the gas
phase and in water. The solvation effect of water on the antioxidant
activity was examined using the conductor–like
polarizable continuum model (C-PCM) at the same level of
theory. The antioxidant action mechanisms for the
investigated naphthoquinone-urazole hybrids were assessed
thermodynamically by several physicochemical parameters.

Keywords

Antioxidant mechanism naphthoquinone-urazole hybrids DFT HAT SET-PT SPLET SPLET

References

  • [1]. Mokini Z., Marcovecchio, M. L., & Chiarelli, F., Molecular pathology of oxidative stress in diabetic angiopathy: role of mitochondrial and cellular pathways, Diabetes Research and Clinical Practice, 87-3 (2010) 313-321.
  • [2]. Kamkar, A., Javan, A. J., Asadi, F., & Kamalinejad, M., The antioxidative effect of Iranian Mentha pulegium extracts and essential oil in sunflower oil, Food and Chemical Toxicology, 48-7 (2010) 1796-1800.
  • [3]. Kovacic, P., & Somanathan, R., Recent developments in the mechanism of anticancer agents based on electron transfer, reactive oxygen species and oxidative stress. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 11-7 (2011) 658-668.
  • [4]. Salustiano, E. J., Netto, C. D., Fernandes, R. F., da Silva, A. J., Bacelar, T. S., Castro, C. P., .. & Costa, P. R., Comparison of the cytotoxic effect of lapachol, α-lapachone and pentacyclic 1, 4-naphthoquinones on human leukemic cells, Investigational new drugs, 28-2 (2011) 139-144.
  • [5]. Gaikwad, P., Barik, A., Priyadarsini, K. I., & Rao, B. S. M., Antioxidant activities of phenols in different solvents using DPPH assay, Research on chemical intermediates, 36-9 (2011) 1065-1072.
  • [6]. Kuwahara, R., Hatate, H., Yuki, T., Murata, H., Tanaka, R., & Hama, Y., Antioxidant property of polyhydroxylated naphthoquinone pigments from shells of purple sea urchin Anthocidaris crassispina, LWT-Food Science and Technology, 42-7 (2009) 1296-1300.
  • [7]. Jacobson, C. R., A. D. Adamo, and C. E. Cosgrove. "US Patent, 3,663,564, 1972." Chem. Abstr. Vol. 76. 1972.
  • [8]. Wellington, K. W., Understanding cancer and the anticancer activities of naphthoquinones–a review. RSC Advances, 5-26 (2015) 20309-20338.
  • [9]. T. Jikihara, K. Matsuya, H. Ohta, S. Suzuki and O. Wakabayashi, US Pat. 4249934 A, 1981, Chem. Abstr., 95 (1981) 62219 y.
  • [10]. R. A. Izydore and I. H. Hall, US Pat. 4866058, 1990, Chem. Abstr.,112 (1990) 151876 x.
  • [11]. B. V. Bredow and H. Brechbuehler, Ger. Offen. 2343347 A1, Chem. Abstr., 80 (1974) 140210 s.
  • [12]. Saluja, P., Khurana, J. M., Nikhil, K., & Roy, P., Task-specific ionic liquid catalyzed synthesis of novel naphthoquinone–urazole hybrids and evaluation of their antioxidant and in vitro anticancer activity. RSC Advances, 4.65 (2014) 34594-34603.
  • [13]. Wright, J. S., Johnson, E. R., & DiLabio, G. A., Predicting the activity of phenolic antioxidants: theoretical method, analysis of substituent effects, and application to major families of antioxidants. Journal of the American Chemical Society, 123-6 (2001) 1173-1183.
  • [14]. Bartmess, J. E., Thermodynamics of the electron and the proton. The Journal of Physical Chemistry, 98-25 (1994) 6420-6424.
  • [15]. Klein, E., Rimarcik, J., & Lukes, V., DFT/B3LYP study of the O–H bond dissociation enthalpies and proton affinities of para-and meta-substituted phenols in water and benzene, Acta Chim. Slovaca, 2-2 (2009) 37-51.
  • [16]. Rimarčík, J., Lukeš, V., Klein, E., & Ilčin, M., Study of the solvent effect on the enthalpies of homolytic and heterolytic N–H bond cleavage in p-phenylenediamine and tetracyano-p-phenylenediamine, Journal of Molecular Structure: THEOCHEM, 952(1-3) (2010) 25-30.
  • [17]. Parker, V. D., Homolytic bond (HA) dissociation free energies in solution. Applications of the standard potential of the (H+/H. bul.) couple, Journal of the American Chemical Society, 114-19 (1992) 7458-7462.
  • [18]. Bizarro, M. M., Cabral, B. J. C., de Santos, R. M. B., & Simões, J. A. M., Substituent effects on the OH bond dissociation enthalpies in phenolic compounds: agreements and controversies, Pure and Applied Chemistry, 71-8 (1999) 1609-1610.
  • [19]. M.A. Robb, J.R. Cheeseman, M.J. Frisch, G.W. Trucks,H.B. Schlegel, G.E. Scuseria, M.A. Robb, J.R. Cheeseman, G. Scalmani, V. Barone, B. Mennucci, G.A. Petersson, H. Nakatsuji,M. Caricato, X. Li,H.p.Hratchian, A.F. Izmaylov, J. Bloino, G. Zheng, J.L. Sonnenberg, M. Hada, M. Ehara, K. Toyota, R. Fukuda, J.Hasegawa, M. Ishida, T. Nakajima, Y. Honda, O. Kitao, H. Nakai, T. Vreven, J.A.Montgomery, Jr., J.E. Peralta, F. Ogliaro,M. Bearpark, J.J. Heyd, E. Brothers, K.N. Kudin, V.N. Staroverov, R. Kobayashi, J. Normand, K. Raghavachari, A. Rendell,J.C. Burant, S.S. Iyengar, J.Tomasi, M. Cossi, N. Rega, J.M. Millam, M.Klene, J.E. Knox, J.B. Cross,V. Bakken, C. Adamo, J.Jaramillo, R. Gompert, R.E. Stratmann, O. Yazyev, A.J. Austin, R. Cammi, C. Pomelli, J.W.Ochterski, R.L. Martin,K. Morokuma, V.G. Zakrzewski, G.A. Voth, P. Salvador, J.J. Dannenberg, S. Dapprich, A.D. Daniels, O. Farkas, J.B. Foresman, J.V.Ortiz, J. Cioslowski, andD.J. Fox, Gaussian 09, Revision C.01 (Gaussian Inc.,Wallingford,CT, (2010).
  • [20]. Becke, A. D., Density‐functional thermochemistry. III. The role of exact exchange, The Journal of chemical physics, 98-7 (1993) 5648-5652.
  • [21]. Cances, E., Mennucci, B., & Tomasi, J., A new integral equation formalism for the polarizable continuum model: Theoretical background and applications to isotropic and anisotropic dielectrics. The Journal of chemical physics, 107-8 (1997) 3032-3041.
  • [22]. Özbakır Işın, D., Theoretical study on the investigation of antioxidant properties of some hydroxyanthraquinones, Molecular Physics, 114-24 (2016) 3578-3588.
  • [23]. Kabanda, M. M., Tran, V. T., Seema, K. M., Serobatse, K. R., Tsiepe, T. J., Tran, Q. T., & Ebenso, E. E., Conformational, electronic and antioxidant properties of lucidone, linderone and methyllinderone: DFT, QTAIM and NBO studies, Molecular Physics, 113-7 (1015) 683-697.
  • [24]. Cai, W., Chen, Y., Xie, L., Zhang, H., & Hou, C., Characterization and density functional theory study of the antioxidant activity of quercetin and its sugar-containing analogues, European Food Research and Technology, 238-1 (2014) 121-128.
  • [25]. Markovic, Zoran S., Slavko V. Mentus, and Jasmina M. Dimitrić Marković., Electrochemical and density functional theory study on the reactivity of fisetin and its radicals: implications on in vitro antioxidant activity, The journal of physical chemistry A 113-51 (2009) 14170-14179.
  • [26]. Leopoldini, M., Russo, N., & Toscano, M., Gas and liquid phase acidity of natural antioxidants, Journal of agricultural and food chemistry, 54-8 (2006) 3078-3085.
  • [27]. Marković, Z., Jeremić, S., Marković, J. D., Pirković, M. S., & Amić, D., Influence of structural characteristics of substituents on the antioxidant activity of some anthraquinone derivatives, Computational and Theoretical Chemistry, 1077 (2016) 25-31.
There are 27 citations in total.

Details

Primary Language English
Journal Section Natural Sciences
Authors

Dilara Özbakır Işın

Publication Date September 30, 2018
Submission Date August 17, 2018
Acceptance Date September 25, 2018
Published in Issue Year 2018

Cite

APA Özbakır Işın, D. (2018). DFT Study on Antioxidant Action Mechanisms of Naphthoquinone-Urazole Hybrids. Cumhuriyet Science Journal, 39(3), 734-744. https://doi.org/10.17776/csj.454294

Cited By

Hybrid Molecules Containing Naphthoquinone and Quinolinedione Scaffolds as Antineoplastic Agents
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https://doi.org/10.3390/molecules27154948