Research Article
BibTex RIS Cite

Year 2022, , 165 - 170, 29.06.2022

Hani Alotaibi

https://doi.org/10.17776/csj.1062126
Cited By: 2

Abstract

Supporting Institution

TÜBİTAK

Project Number

219Z034

References

  • [1] Chen T., You Y., Jiang H., Wang Z.Z., Epithelial-mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis, J. Cell Physiol, 232(12) (2017) 3261-3272.
  • [2] Chen J., Han Q., Pei D., EMT and MET as paradigms for cell fate switching, J. Mol. Cell Biol., 4(2) (2012) 66-69.
  • [3] Kim D.H., Xing T., Yang Z., Dudek R., Lu Q., Chen Y.H., Epithelial Mesenchymal Transition in Embryonic Development, Tissue Repair and Cancer: A Comprehensive Overview, J. Clin. Med., 7(1) (2017).
  • [4] Banyard J., Bielenberg D.R., The role of EMT and MET in cancer dissemination, Connect Tissue Res., 56(5) (2015) 403-413.
  • [5] Brabletz T., Kalluri R., Nieto M.A., Weinberg R.A., EMT in cancer, Nat Rev Cancer, 18(2) (2018) 128-134.
  • [6] Chaffer C.L., San Juan B.P., Lim E., Weinberg R.A., EMT, cell plasticity and metastasis, Cancer Metastasis Rev., 35(4) (2016) 645-654.
  • [7] Kalluri R., EMT: when epithelial cells decide to become mesenchymal-like cells, J. Clin. Invest, 119(6) (2009) 1417-1419.
  • [8] Sayan A.E., Tumour-promoting role of EMT-inducing transcription factor ZEB1 in mantle cell lymphoma, Cell Death Differ, 21(2) (2014) 194-195.
  • [9] Wheelock M.J., Shintani Y., Maeda M., Fukumoto Y., Johnson K.R., Cadherin switching, J. Cell. Sci., 121 (Pt 6) (2008) 727-735.
  • [10] Alotaibi H., Basilicata M.F., Shehwana H., Kosowan T., Schreck I., Braeutigam C., Konu O., Brabletz T., Stemmler M.P., Enhancer cooperativity as a novel mechanism underlying the transcriptional regulation of E-cadherin during mesenchymal to epithelial transition, Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1849(6) (2015) 731-742.
  • [11] Li Q., Hutchins A.P., Chen Y., Li S., Shan Y., Liao B., Zheng D., Shi X., Li Y., Chan W.Y., Pan G., Wei S., Shu X., Pei D., A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes, Nat. Commun., 8 (2017) 15166.
  • [12] Li R., Liang J., Ni S., Zhou T., Qing X., Li H., He W., Chen J., Li F., Zhuang Q., Qin B., Xu J., Li W., Yang J., Gan Y., Qin D., Feng S., Song H., Yang D., Zhang B., Zeng L., Lai L., Esteban M.A., Pei D., A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts, Cell Stem Cell, 7(1) (2010) 51-63.
  • [13] Werth M., Walentin K., Aue A., Schonheit J., Wuebken A., Pode-Shakked N., Vilianovitch L., Erdmann B., Dekel B., Bader M., Barasch J., Rosenbauer F., Luft F.C., Schmidt-Ott K.M., The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex, Development, 137(22) (2010) 3835-3845.
  • [14] Haensel D., Sun P., MacLean A.L., Ma X., Zhou Y., Stemmler M.P., Brabletz S., Berx G., Plikus M.V., Nie Q., Brabletz T., Dai X., An Ovol2-Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation, EMBO Rep., 20(1) (2019).
  • [15] Watanabe K., Liu Y., Noguchi S., Murray M., Chang J.C., Kishima M., Nishimura H., Hashimoto K., Minoda A., Suzuki H., OVOL2 induces mesenchymal-to-epithelial transition in fibroblasts and enhances cell-state reprogramming towards epithelial lineages, Sci. Rep., 9(1) (2019) 6490.
  • [16] Sengez B., Aygun I., Shehwana H., Toyran N., Tercan Avci S., Konu O., Stemmler M.P., Alotaibi H., The Transcription Factor Elf3 Is Essential for a Successful Mesenchymal to Epithelial Transition, Cells, 8(8) (2019).
  • [17] Brown A., Rathore S., Kimanius D., Aibara S., Bai X.C., Rorbach J., Amunts A., Ramakrishnan V., Structures of the human mitochondrial ribosome in native states of assembly, Nat Struct Mol Biol., 24(10) (2017) 866-869.
  • [18] Park K.C., Song K.H., Chung H.K., Kim H., Kim D.W., Song J.H., Hwang E.S., Jung H.S., Park S.H., Bae I., Lee I.K., Choi H.S., Shong M., CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation, Mol. Endocrinol., 19(1) (2005) 12-24.
  • [19] Kwon M.C., Koo B.K., Kim Y.Y., Lee S.H., Kim N.S., Kim J.H., Kong Y.Y., Essential role of CR6-interacting factor 1 (Crif1) in E74-like factor 3 (ELF3)-mediated intestinal development, J Biol Chem., 284 (48) (2009) 33634-33641.
  • [20] Bedzhov I., Alotaibi H., Basilicata M.F., Ahlborn K., Liszewska E., Brabletz T., Stemmler M.P., Adhesion, but not a specific cadherin code, is indispensable for ES cell and induced pluripotency, Stem. Cell Res., 11(3) (2013) 1250-1263.
  • [21] Brembeck F.H., Opitz O.G., Libermann T.A., Rustgi A.K., Dual function of the epithelial specific ets transcription factor, ELF3, in modulating differentiation, Oncogene, 19(15) (2000) 1941-1949.
  • [22] Kitazawa K., Hikichi T., Nakamura T., Mitsunaga K., Tanaka A., Nakamura M., Yamakawa T., Furukawa S., Takasaka M., Goshima N., Watanabe A., Okita K., Kawasaki S., Ueno M., Kinoshita S., Masui S., OVOL2 Maintains the Transcriptional Program of Human Corneal Epithelium by Suppressing Epithelial-to-Mesenchymal Transition, Cell Rep., 15(6) (2016) 1359-1368.
  • [23] Roca H., Hernandez J., Weidner S., McEachin R.C., Fuller D., Sud S., Schumann T., Wilkinson J.E., Zaslavsky A., Li H., Maher C.A., Daignault-Newton S., Healy P.N., Pienta K.J., Transcription factors OVOL1 and OVOL2 induce the mesenchymal to epithelial transition in human cancer, PLoS One, 8(10) (2013) e76773.
  • [24] Alotaibi H., Transcriptional Impact of E-cadherin Loss on Embryonic Stem Cells, Jordan Journal of Biological Sciences, 14(5) (2021) 1035-1043.
  • [25] Amunts A., Brown A., Toots J., Scheres S.H.W., Ramakrishnan V., Ribosome. The structure of the human mitochondrial ribosome, Science, 348 (6230) (2015) 95-98.
  • [26] He J., Cooper H.M., Reyes A., Di Re M., Sembongi H., Litwin T.R., Gao J., Neuman K.C., Fearnley I.M., Spinazzola A., Walker J.E., Holt I.J., Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis, Nucleic Acids Res., 40(13) (2012) 6109-6121.
  • [27] Chung H.K., Yi Y.W., Jung N.C., Kim D., Suh J.M., Kim H., Park K.C., Song J.H., Kim D.W., Hwang E.S., Yoon S.H., Bae Y.S., Kim J.M., Bae I., Shong M., CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle, J. Biol. Chem., 278(30) (2003) 28079-28088.
  • [28] Ran Q., Hao P., Xiao Y., Xiang L., Ye X., Deng X., Zhao J., Li Z., CRIF1 interacting with CDK2 regulates bone marrow microenvironment-induced G0/G1 arrest of leukemia cells, PLoS One, 9(2) (2014) e85328.

Crif1 is Required for Proper Mesenchymal to Epithelial Transition

Year 2022, , 165 - 170, 29.06.2022

Hani Alotaibi

https://doi.org/10.17776/csj.1062126
Cited By: 2

Abstract

The epithelial to mesenchymal and the mesenchymal to epithelial transitions (EMT and MET) are fundamental developmental processes required for shaping the embryo but are also hijacked by cancer cells during metastasis. The regulation of EMT is very well studied, and major regulators have been identified. A similar understanding of the regulation of MET is needed. Recently we and others have described essential factors for the initiation and progression of MET; among them is the ETS transcription factor Elf3. Recent reports showed that Crif1 is critical for the function of Elf3, yet the influence on MET has not been reported. Here, we studied the involvement of Crif1 in MET using a loss of function approach in NMuMG cells. We found that the depletion of Crif1 resulted in an impaired MET. We have also noticed that Cdh1 mRNA and protein expression was not affected; instead, E-cadherin, the protein product of Cdh1, was localized to the cytoplasm. These results are in agreement with our previous findings following the depletion of Elf3. In conclusion, Crif1 was essential for the mesenchymal to epithelial transition, and it may exert its function in cooperation with Elf3

Keywords

EMT Elf3 Crif1

Project Number

219Z034

References

  • [1] Chen T., You Y., Jiang H., Wang Z.Z., Epithelial-mesenchymal transition (EMT): A biological process in the development, stem cell differentiation, and tumorigenesis, J. Cell Physiol, 232(12) (2017) 3261-3272.
  • [2] Chen J., Han Q., Pei D., EMT and MET as paradigms for cell fate switching, J. Mol. Cell Biol., 4(2) (2012) 66-69.
  • [3] Kim D.H., Xing T., Yang Z., Dudek R., Lu Q., Chen Y.H., Epithelial Mesenchymal Transition in Embryonic Development, Tissue Repair and Cancer: A Comprehensive Overview, J. Clin. Med., 7(1) (2017).
  • [4] Banyard J., Bielenberg D.R., The role of EMT and MET in cancer dissemination, Connect Tissue Res., 56(5) (2015) 403-413.
  • [5] Brabletz T., Kalluri R., Nieto M.A., Weinberg R.A., EMT in cancer, Nat Rev Cancer, 18(2) (2018) 128-134.
  • [6] Chaffer C.L., San Juan B.P., Lim E., Weinberg R.A., EMT, cell plasticity and metastasis, Cancer Metastasis Rev., 35(4) (2016) 645-654.
  • [7] Kalluri R., EMT: when epithelial cells decide to become mesenchymal-like cells, J. Clin. Invest, 119(6) (2009) 1417-1419.
  • [8] Sayan A.E., Tumour-promoting role of EMT-inducing transcription factor ZEB1 in mantle cell lymphoma, Cell Death Differ, 21(2) (2014) 194-195.
  • [9] Wheelock M.J., Shintani Y., Maeda M., Fukumoto Y., Johnson K.R., Cadherin switching, J. Cell. Sci., 121 (Pt 6) (2008) 727-735.
  • [10] Alotaibi H., Basilicata M.F., Shehwana H., Kosowan T., Schreck I., Braeutigam C., Konu O., Brabletz T., Stemmler M.P., Enhancer cooperativity as a novel mechanism underlying the transcriptional regulation of E-cadherin during mesenchymal to epithelial transition, Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms, 1849(6) (2015) 731-742.
  • [11] Li Q., Hutchins A.P., Chen Y., Li S., Shan Y., Liao B., Zheng D., Shi X., Li Y., Chan W.Y., Pan G., Wei S., Shu X., Pei D., A sequential EMT-MET mechanism drives the differentiation of human embryonic stem cells towards hepatocytes, Nat. Commun., 8 (2017) 15166.
  • [12] Li R., Liang J., Ni S., Zhou T., Qing X., Li H., He W., Chen J., Li F., Zhuang Q., Qin B., Xu J., Li W., Yang J., Gan Y., Qin D., Feng S., Song H., Yang D., Zhang B., Zeng L., Lai L., Esteban M.A., Pei D., A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts, Cell Stem Cell, 7(1) (2010) 51-63.
  • [13] Werth M., Walentin K., Aue A., Schonheit J., Wuebken A., Pode-Shakked N., Vilianovitch L., Erdmann B., Dekel B., Bader M., Barasch J., Rosenbauer F., Luft F.C., Schmidt-Ott K.M., The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex, Development, 137(22) (2010) 3835-3845.
  • [14] Haensel D., Sun P., MacLean A.L., Ma X., Zhou Y., Stemmler M.P., Brabletz S., Berx G., Plikus M.V., Nie Q., Brabletz T., Dai X., An Ovol2-Zeb1 transcriptional circuit regulates epithelial directional migration and proliferation, EMBO Rep., 20(1) (2019).
  • [15] Watanabe K., Liu Y., Noguchi S., Murray M., Chang J.C., Kishima M., Nishimura H., Hashimoto K., Minoda A., Suzuki H., OVOL2 induces mesenchymal-to-epithelial transition in fibroblasts and enhances cell-state reprogramming towards epithelial lineages, Sci. Rep., 9(1) (2019) 6490.
  • [16] Sengez B., Aygun I., Shehwana H., Toyran N., Tercan Avci S., Konu O., Stemmler M.P., Alotaibi H., The Transcription Factor Elf3 Is Essential for a Successful Mesenchymal to Epithelial Transition, Cells, 8(8) (2019).
  • [17] Brown A., Rathore S., Kimanius D., Aibara S., Bai X.C., Rorbach J., Amunts A., Ramakrishnan V., Structures of the human mitochondrial ribosome in native states of assembly, Nat Struct Mol Biol., 24(10) (2017) 866-869.
  • [18] Park K.C., Song K.H., Chung H.K., Kim H., Kim D.W., Song J.H., Hwang E.S., Jung H.S., Park S.H., Bae I., Lee I.K., Choi H.S., Shong M., CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation, Mol. Endocrinol., 19(1) (2005) 12-24.
  • [19] Kwon M.C., Koo B.K., Kim Y.Y., Lee S.H., Kim N.S., Kim J.H., Kong Y.Y., Essential role of CR6-interacting factor 1 (Crif1) in E74-like factor 3 (ELF3)-mediated intestinal development, J Biol Chem., 284 (48) (2009) 33634-33641.
  • [20] Bedzhov I., Alotaibi H., Basilicata M.F., Ahlborn K., Liszewska E., Brabletz T., Stemmler M.P., Adhesion, but not a specific cadherin code, is indispensable for ES cell and induced pluripotency, Stem. Cell Res., 11(3) (2013) 1250-1263.
  • [21] Brembeck F.H., Opitz O.G., Libermann T.A., Rustgi A.K., Dual function of the epithelial specific ets transcription factor, ELF3, in modulating differentiation, Oncogene, 19(15) (2000) 1941-1949.
  • [22] Kitazawa K., Hikichi T., Nakamura T., Mitsunaga K., Tanaka A., Nakamura M., Yamakawa T., Furukawa S., Takasaka M., Goshima N., Watanabe A., Okita K., Kawasaki S., Ueno M., Kinoshita S., Masui S., OVOL2 Maintains the Transcriptional Program of Human Corneal Epithelium by Suppressing Epithelial-to-Mesenchymal Transition, Cell Rep., 15(6) (2016) 1359-1368.
  • [23] Roca H., Hernandez J., Weidner S., McEachin R.C., Fuller D., Sud S., Schumann T., Wilkinson J.E., Zaslavsky A., Li H., Maher C.A., Daignault-Newton S., Healy P.N., Pienta K.J., Transcription factors OVOL1 and OVOL2 induce the mesenchymal to epithelial transition in human cancer, PLoS One, 8(10) (2013) e76773.
  • [24] Alotaibi H., Transcriptional Impact of E-cadherin Loss on Embryonic Stem Cells, Jordan Journal of Biological Sciences, 14(5) (2021) 1035-1043.
  • [25] Amunts A., Brown A., Toots J., Scheres S.H.W., Ramakrishnan V., Ribosome. The structure of the human mitochondrial ribosome, Science, 348 (6230) (2015) 95-98.
  • [26] He J., Cooper H.M., Reyes A., Di Re M., Sembongi H., Litwin T.R., Gao J., Neuman K.C., Fearnley I.M., Spinazzola A., Walker J.E., Holt I.J., Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis, Nucleic Acids Res., 40(13) (2012) 6109-6121.
  • [27] Chung H.K., Yi Y.W., Jung N.C., Kim D., Suh J.M., Kim H., Park K.C., Song J.H., Kim D.W., Hwang E.S., Yoon S.H., Bae Y.S., Kim J.M., Bae I., Shong M., CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle, J. Biol. Chem., 278(30) (2003) 28079-28088.
  • [28] Ran Q., Hao P., Xiao Y., Xiang L., Ye X., Deng X., Zhao J., Li Z., CRIF1 interacting with CDK2 regulates bone marrow microenvironment-induced G0/G1 arrest of leukemia cells, PLoS One, 9(2) (2014) e85328.
There are 28 citations in total.

Details

Primary Language English
Subjects Structural Biology
Journal Section Natural Sciences
Authors

Hani Alotaibi 0000-0001-7423-9653

Project Number 219Z034
Publication Date June 29, 2022
Submission Date January 24, 2022
Acceptance Date April 9, 2022
Published in Issue Year 2022

Cite

APA Alotaibi, H. (2022). Crif1 is Required for Proper Mesenchymal to Epithelial Transition. Cumhuriyet Science Journal, 43(2), 165-170. https://doi.org/10.17776/csj.1062126

Cited By

Phenotypic Transitions the Processes Involved in Regulation of Growth and Proangiogenic Properties of Stem Cells, Cancer Stem Cells and Circulating Tumor Cells
Stem Cell Reviews and Reports
https://doi.org/10.1007/s12015-024-10691-w
The transcription factor ELF5 is essential for early preimplantation development
Molecular Biology Reports
https://doi.org/10.1007/s11033-022-08217-z