Despite the fact that narcotics and NSAIDs are the mainstays of nociceptive pain care, only a small proportion of neuropathic pain patients benefit from them. Cannabinoid agents could be a viable alternative to opioids in the management of chronic pain. The goal of our investigation was to assess the analgesic efficacy of SER 601 and L-759,633, cannabinoid receptor 2 (CB2) agonists, at various doses in a model of neuropathic pain generated in rat. The analgesic effect of CB2 agonists L-759,633 and SER 601 at various doses in a rat model of neuropathic pain created by partial sciatic nerve ligation was examined by the hot plate method. Furthermore, a comparison of analgesic effects of both drugs with pregabalin is also conducted. The two substances demonstrated a dose-dependent analgesic effect in this model. The analgesic response of SER601 and L-759,633 in the neuropathic pain model was higher compared to that of pregabalin. All in all, our data suggest that SER601 and L-759,633 may offer a beneficial treatment option for neuropathic pain in future.
cumhuriyet university scientific research project
T-848
T-848
Birincil Dil | İngilizce |
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Konular | Eczacılık ve İlaç Bilimleri |
Bölüm | Natural Sciences |
Yazarlar | |
Proje Numarası | T-848 |
Yayımlanma Tarihi | 26 Mart 2023 |
Gönderilme Tarihi | 21 Ocak 2022 |
Kabul Tarihi | 6 Şubat 2023 |
Yayımlandığı Sayı | Yıl 2023 |