Öz
Omiks bilim ve tıp alanında önemli yönleri ile gelişmekte olan bir alandır. Omiks ile genomiks, epigenomiks, transkriptomiks, proteomiks, metabolomiks ve biyoinformatiksi içinde alan çeşitli heyecan verici gelişmeler sağlanmıştır. Sistemler tıbbı da biyolojik sistemlerdeki karmaşık ilişkileri araştırmak için yeni yaklaşımlar ortaya koyan yeni ortaya çıkmış bilimsel bir alandır.
Anahtar Kelimeler
Kaynakça
- Cusick ME, Klitgord N, Vidal M, Hill DE. Interactome: gateway into systems biology. Hum Mol Genet. 2005 Oct 15;14 Spec No. 2:R171-81. PMID: 16162640.
- Ng A, Bursteinas B, Gao Q, Mollison E, Zvelebil M. Resources for integrative systems biology: from data through databases to networks and dynamic system models. Brief Bioinform. 2006 Dec;7(4):318-30. PMID: 17040977.
- Janssens AC, van Duijn CM. Genome-based prediction of common diseases: methodological considerations for future research. Genome Med. 2009 Feb 18;1(2):20. PMID: 19341491.
- Van QN, Veenstra TD. How close is the bench to the bedside? Metabolic profiling in cancer research. Genome Med. 2009 Jan 20;1(1):5. PMID: 19348692.
- Auffray C, Chen Z, Hood L. Systems medicine: the future of medical genomics and healthcare. Genome Med. 2009 Jan 20;1(1):2. PMID: 19348689.
- Wist AD, Berger SI, Iyengar R. Systems pharmacology and genome medicine: a future perspective. Genome Med. 2009 Jan 22;1(1):11. PMID: 19348698.
- Kaelin WG Jr. Synthetic lethality: a framework for the development of wiser cancer therapeutics. Genome Med. 2009 Oct 27;1(10):99. PMID: 19863774.
- Taylor AD, Hancock WS, Hincapie M, Taniguchi N, Hanash SM. Towards an integrated proteomic and glycomic approach to finding cancer biomarkers. Genome Med. 2009 Jun 4;1(6):57. PMID: 19519948.
- Williams RW. Expression genetics and the phenotype revolution. Mamm Genome. 2006 Jun;17(6):496-502. PMID: 16783631.
- Galasso M, Elena Sana M, Volinia S. Non-coding RNAs: a key to future personalized molecular therapy? Genome Med. 2010 Feb 18;2(2):12. PMID: 20236487.
- Oresic M. Metabolomics, a novel tool for studies of nutrition, metabolism and lipid dysfunction. Nutr Metab Cardiovasc Dis. 2009 Dec;19(11):816-24. PMID: 19692215. Houle D, Govindaraju DR, Omholt S. Phenomics: the next challenge. Nat Rev Genet. 2010 Dec;11(12):855-66. PMID: 21085204.
- Dolinoy DC, Jirtle RL. Environmental epigenomics in human health and disease. Environ Mol Mutagen. 2008 Jan;49(1):4-8. PMID: 18172876.
Öz
Abstract
Omics is an emerging area that has many aspects in the field of science and medicine. Several exiting developments have been achieved with omics including genomics, epigenomics, transcriptomics, proteomics, metabolomics, and bioinformatics. Systems biology is another emerging scientific area to develop new approaches for investigating complex interactions within biological systems.
Keywords: Omics, systems medicine
ÖzetOmiks bilim ve tıp alanında önemli yönleri ile gelişmekte olan bir alandır. Omiks ile genomiks, epigenomiks, transkriptomiks, proteomiks, metabolomiks ve biyoinformatiksi içinde alan çeşitli heyecan verici gelişmeler sağlanmıştır. Sistemler tıbbı da biyolojik sistemlerdeki karmaşık ilişkileri araştırmak için yeni yaklaşımlar ortaya koyan yeni ortaya çıkmış bilimsel bir alandır.
Anahtar sözcükler: Omiks, sistem tıbbı
Anahtar Kelimeler
Kaynakça
- Cusick ME, Klitgord N, Vidal M, Hill DE. Interactome: gateway into systems biology. Hum Mol Genet. 2005 Oct 15;14 Spec No. 2:R171-81. PMID: 16162640.
- Ng A, Bursteinas B, Gao Q, Mollison E, Zvelebil M. Resources for integrative systems biology: from data through databases to networks and dynamic system models. Brief Bioinform. 2006 Dec;7(4):318-30. PMID: 17040977.
- Janssens AC, van Duijn CM. Genome-based prediction of common diseases: methodological considerations for future research. Genome Med. 2009 Feb 18;1(2):20. PMID: 19341491.
- Van QN, Veenstra TD. How close is the bench to the bedside? Metabolic profiling in cancer research. Genome Med. 2009 Jan 20;1(1):5. PMID: 19348692.
- Auffray C, Chen Z, Hood L. Systems medicine: the future of medical genomics and healthcare. Genome Med. 2009 Jan 20;1(1):2. PMID: 19348689.
- Wist AD, Berger SI, Iyengar R. Systems pharmacology and genome medicine: a future perspective. Genome Med. 2009 Jan 22;1(1):11. PMID: 19348698.
- Kaelin WG Jr. Synthetic lethality: a framework for the development of wiser cancer therapeutics. Genome Med. 2009 Oct 27;1(10):99. PMID: 19863774.
- Taylor AD, Hancock WS, Hincapie M, Taniguchi N, Hanash SM. Towards an integrated proteomic and glycomic approach to finding cancer biomarkers. Genome Med. 2009 Jun 4;1(6):57. PMID: 19519948.
- Williams RW. Expression genetics and the phenotype revolution. Mamm Genome. 2006 Jun;17(6):496-502. PMID: 16783631.
- Galasso M, Elena Sana M, Volinia S. Non-coding RNAs: a key to future personalized molecular therapy? Genome Med. 2010 Feb 18;2(2):12. PMID: 20236487.
- Oresic M. Metabolomics, a novel tool for studies of nutrition, metabolism and lipid dysfunction. Nutr Metab Cardiovasc Dis. 2009 Dec;19(11):816-24. PMID: 19692215. Houle D, Govindaraju DR, Omholt S. Phenomics: the next challenge. Nat Rev Genet. 2010 Dec;11(12):855-66. PMID: 21085204.
- Dolinoy DC, Jirtle RL. Environmental epigenomics in human health and disease. Environ Mol Mutagen. 2008 Jan;49(1):4-8. PMID: 18172876.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Bölüm | Basic Sciences |
| Yazarlar | |
| Yayımlanma Tarihi | 5 Nisan 2013 |
| Yayımlandığı Sayı | Yıl 2013 Cilt: 2 Sayı: 1 |