Abstract
References
- Abdulillah Ece, Biruni Üniversity. aece@biruni.edu.tr
- Cenk Andaç, İstinye Üniversity cenk_andac@yahoo.com
Extracts of Mesua Ferrea Linn, the natural Inhibitors of COVID-19 main protease: a computational quest
Abstract
The coronavirus, known as severe acute respiratory syndrome (SARS-CoV-2), is accountable for the global epidemic disease COVID-19. The effective treatment of this disease is still unknown and there is an emergent need to use all resources to find the effective medication. The use of off-label natural medicinal compounds may be effective remedy for this scourge. Towards the investigation of effective inhibitor of 3CL protease, we studied the in silico interaction of the selected compounds of Mesua Ferrae Linn, an Asian medicinal plant. The studied compounds have shown excellent inhibition properties. The timber extracts, Mesuabixanthone-B (∆Gbind = -15.51 kcal/mol) and Mesuferrol-B (∆Gbind = -14.32 kcal/mol) are among the exciting hits on 6LU7. The in silico prediction of toxicities of the extracts are also promising. The further lab research is necessary to testify these drug candidates against COVID-19 infections.
Keywords
References
- Abdulillah Ece, Biruni Üniversity. aece@biruni.edu.tr
- Cenk Andaç, İstinye Üniversity cenk_andac@yahoo.com
Details
| Primary Language | English |
|---|---|
| Subjects | Biochemistry and Cell Biology (Other) |
| Journal Section | Articles |
| Authors | |
| Publication Date | May 30, 2021 |
| Submission Date | December 28, 2020 |
| Acceptance Date | April 9, 2021 |
| Published in Issue | Year 2021 Volume: 2 Issue: 2 |
Turkish Journal of Science and Health (TFSD)
E-mail: tfsdjournal@gmail.com
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