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The Relationship The Leptin Hormone, Obesity and Diabetes

Year 2020, Volume: 15 Issue: 2, 40 - 48, 23.04.2020

Abstract

           Leptin, which is adipocytes, secreted of the hormone, over food intake regulation, energy expenditure has also an important role in acting as neuroendocrine hormone, and metabolic function.it is interested in glucose metabolism and interacts with insulin metabolism. In addition to distrusting metabolism, leptin also impairs endocrine, immune functions, reproductive function, adipose tissue metabolism and energy order. Leptin also exerts peripheral effects directly on glucose metabolism and gluconeogenesis. it is obvious that leptin deficiency or leptin resistance is responsible for obesity which is also correlated with body fat stores, here we have to refer that is the obesity is one of the most causes of diabetes also it leads to insulin resistance. In these studies, we will focus on the relationship between leptin and diabetes mellitus type 2 and insulin resistance with obesity. In this study, we will focus on the relationship between the leptin hormone and obesity with diabetes. 

References

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Year 2020, Volume: 15 Issue: 2, 40 - 48, 23.04.2020

Abstract

References

  • [1] Hussain, Z. and Khan, J.A., (2017). Food Intake Regulation by Leptin: Mechanisms Mediating Gluconeogenesis and Energy Expenditure, 10(10):940-944.
  • [2] Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., and Friedman, J.M.J.N., (1994). Positional Cloning of the Mouse Obese Gene and Its Human Homologue, 372(6505):425.
  • [3] Faust, I.M., Johnson, P.R., and Hirsch, J.J.S., (1977). Adipose Tissue Regeneration Following Lipectomy, 197(4301):391-393.
  • [4] Harris, R.B., (1990). Role of Set-Point Theory in Regulation of Body Weight, 4(15):3310-3318.
  • [5] Sari, A., (2013). The Relationship Between Leptin and Fatty Acid, 4(139):2.
  • [6] Meier, U. and Gressner, A.M., (2004). Endocrine Regulation of Energy Metabolism: Review of Pathobiochemical and Clinical Chemical Aspects of Leptin, Ghrelin, Adiponectin, and Resistin, 50(9):1511-1525.
  • [7] Halaas, J.L., Boozer, C., Blair-West, J., Fidahusein, N., Denton, D.A., and Friedman, J.M., (1997). Physiological Response to Long-term Peripheral and Central Leptin Infusion in Lean and Obese Mice, 94(16):8878-8883.
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  • [9] Halaas, J.L., Gajiwala, K.S., Maffei, M., Cohen, S.L., Chait, B.T., Rabinowitz, D., Lallone, R.L., Burley, S.K., and Friedman, J.M., (1995). Weight-reducing Effects of the Plasma Protein Encoded by the Obese Gene, 269(5223):543-546.
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  • [11] Flier, J.S., (1998). What’s in a Name? In Search of Leptin’s Physiologic Role, 83(5):1407-1413.
  • [12] Friedman, J.M. and Halaas, J.L., (1998). Leptin and the Regulation of Body Weight in Mammals, 395(6704):763.
  • [13] Allison, D.B., Fontaine, K.R., Manson, J.E., Stevens, J., and VanItallie, T.B.J.J., (1999). Annual Deaths Attributable to Obesity in the United States, 282(16):1530-1538.
  • [14] Mokdad, A.H., Bowman, B.A., Ford, E.S., Vinicor, F., Marks, J.S., and Koplan, J.P., (2001). The Continuing Epidemics of Obesity and Diabetes in the United States, 286(10):1195-1200.
  • [15] Nilsson, C., Niklasson, M., Eriksson, E., Björntorp, P., and Holmäng, A.J.T., (1998). Imprinting of Female Offspring with Testosterone Results in Insulin Resistance and Changes in Body Fat Distribution at Adult Age in Rats, 101(1):74-78.
  • [16] Krssak, M., Petersen, K.F., Dresner, A., DiPietro, L., Vogel, S., Rothman, D., Shulman, G., and Roden, M.J.D., (1999). Intramyocellular Lipid Concentrations are Correlated with Insulin Sensitivity in Humans: a 1H NMR Spectroscopy Study, 42(1):113-116.
  • [17] Diagnosis and Classification of Diabetes Mellitus, (2013). American Diabetes Association, 36(Supplement 1):S67-S74.
  • [18] Esteghamati, A., Gouya, M.M., Abbasi, M., Delavari, A., Alikhani, S., Alaedini, F., Safaie, A., Forouzanfar, M., and Gregg, E.W., (2008). Prevalence of Diabetes and Impaired Fasting Glucose in the Adult Population of Iran: National Survey of Risk Factors for Non-Communicable Diseases of Iran, 31(1):96-98.
  • [19] Wang, B., Charukeshi C.P., and Pippin, J., (2014). Leptin-and Leptin Receptor-Deficient Rodent Models: Relevance for Human Type 2 Diabetes, 10(2):131-145.
  • [20] Atlas, D.J., (2015). Brussels, Belgium: International Diabetes Federation, International Diabetes Federation. 7th edn.
  • [21] Mcneely, M.J., Boyko, E.J., Weigle, D.S., Shofer, J.B., Chessler, S.D., Leonnetti, D.L., and Fujimoto, W.Y., (1999). Association Between Baseline Plasma Leptin Levels and Subsequent Development of Diabetes in Japanese Americans, 22(1):65-70.
  • [22] Kahn, S.E., Hull, R.L., and Utzschneider, K.M.J.N., (2006). Mechanisms Linking Obesity to Insulin Resistance and Type 2 Diabetes, 444(7121):840.
  • [23] Røder, M.E., Porte Jr, D., Schwartz, R.S., and Kahn, S.E., (1998). Disproportionately Elevated Proinsulin Levels Reflect the Degree of Impaired B Cell Secretory Capacity in Patients with Noninsulin-Dependent Diabetes Mellitus, 83(2):604-608.
  • [24] Al-Goblan, A.S., Al-Alfi, M.A., and Khan, M.Z., (2014). Mechanism Linking Diabetes Mellitus and Obesity, 7:587.
  • [25] Nutr, A.J.C., (1998). Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults, 6(Suppl 2):51S-209S.
  • [26] Morton, G.J. and Schwartz, M.W., (2011). Leptin and the Central Nervous System Control of Glucose Metabolism, 91(2):389-411.
  • [27] Dubuc, P.U., (1976). The Development of Obesity, Hyperinsulinemia, and Hyperglycemia in ob/ob Mice, 25(12):1567-1574.
  • [28] Wyse, B. and Dulin, W.J.D., (1970). The Influence of Age and Dietary Conditions on Diabetes in the db Mouse, 6(3):268-273.
  • [29] Pelleymounter, M.A., Cullen, M.J., Baker, M.B., Hecht, R., Winters, D., Boone, T., and Collins, F.J.S., (1995). Effects of the Obese Gene Product on Body Weight Regulation in ob/ob Mice, 269(5223):540-543.
  • [30] Shimomura, I., Hammer, R.E., Ikemoto, S., Brown, M.S., and Goldstein, J.L., (1999. Leptin Reverses Insulin Resistance and Diabetes Mellitus in Mice with Congenital lipodystrophy, 401(6748):73.
  • [31] Petersen, K.F., Oral, E.A., Dufour, S., Befroy, D., Ariyan, C., Yu, C., Cline, G.W., DePaoli, A.M., Taylor, S.I., and Gorden, P.J., (2002). Leptin Reverses Insulin Resistance and Hepatic Steatosis in Patients with Severe Lipodystrophy, 109(10):1345-1350.
  • [32] Patni, N. and Garg, A.J., (2015). Congenital Generalized Lipodystrophies—new Insights into Metabolic Dysfunction, 11(9):522.
  • [33] Meek, T.H. and Morton, G.J., (2016). The Role of Leptin in Diabetes: Metabolic Effects, 59(5):928-932.
  • [34] Fujikawa, T., Chuang, J.-C., Sakata, I., Ramadori, G., and Coppari, R.J., 2010. Leptin Therapy Improves Insulin-Deficient Type 1 Diabetes by CNS-dependent Mechanisms in Mice, 107(40):17391-17396.
  • [35] German, J.P., Thaler, J.P., Wisse, B.E., oh-I, S., Sarruf, D.A., Matsen, M.E., Fischer, J.D., Taborsky Jr, G.J., Schwartz, M.W., and Morton, G.J.J.E., (2010). Leptin Activates a Novel CNS Mechanism for Insulin-independent Normalization of Severe Diabetic Hyperglycemia, 152(2):394-404.
  • [36] Hidaka, S., Yoshimatsu, H., Kondou, S., Tsuruta, Y., Oka, K., Noguchi, H., Okamoto, K., Sakino, H., Teshima, Y., and Okeda, T.J., (2002). Chronic Central Leptin Infusion Restores Hyperglycemia Independent of Food Intake and Insulin Level in Streptozotocin-Induced Diabetic Rats, 16(6):509-518.
  • [37] Lin, C.Y., Higginbotham, D.A., Judd, R.L., and White, B.D., (2002). Central Leptin Increases Insulin Sensitivity in Streptozotocin-induced Diabetic Rats, 282(5):E1084-E1091.
  • [38] Wauters, M., Considine, R.V., and Van Gaal, L.F., (2000. Human Leptin: From an Adipocyte Hormone to an Endocrine Mediator, 143(3):293-311.
  • [39] Taylor, S.I., Barr, V., and Reitman, M.J.S., (1996). Does Leptin Contribute to Diabetes Caused by Obesity?, 274(5290):1151-1151.
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There are 76 citations in total.

Details

Primary Language English
Subjects Engineering
Journal Section Articles
Authors

Aysel Sarı 0000-0002-4966-2254

Mateen Bahjat Sadeq This is me

Publication Date April 23, 2020
Published in Issue Year 2020 Volume: 15 Issue: 2

Cite

APA Sarı, A., & Sadeq, M. B. (2020). The Relationship The Leptin Hormone, Obesity and Diabetes. Physical Sciences, 15(2), 40-48.
AMA Sarı A, Sadeq MB. The Relationship The Leptin Hormone, Obesity and Diabetes. Physical Sciences. April 2020;15(2):40-48.
Chicago Sarı, Aysel, and Mateen Bahjat Sadeq. “The Relationship The Leptin Hormone, Obesity and Diabetes”. Physical Sciences 15, no. 2 (April 2020): 40-48.
EndNote Sarı A, Sadeq MB (April 1, 2020) The Relationship The Leptin Hormone, Obesity and Diabetes. Physical Sciences 15 2 40–48.
IEEE A. Sarı and M. B. Sadeq, “The Relationship The Leptin Hormone, Obesity and Diabetes”, Physical Sciences, vol. 15, no. 2, pp. 40–48, 2020.
ISNAD Sarı, Aysel - Sadeq, Mateen Bahjat. “The Relationship The Leptin Hormone, Obesity and Diabetes”. Physical Sciences 15/2 (April 2020), 40-48.
JAMA Sarı A, Sadeq MB. The Relationship The Leptin Hormone, Obesity and Diabetes. Physical Sciences. 2020;15:40–48.
MLA Sarı, Aysel and Mateen Bahjat Sadeq. “The Relationship The Leptin Hormone, Obesity and Diabetes”. Physical Sciences, vol. 15, no. 2, 2020, pp. 40-48.
Vancouver Sarı A, Sadeq MB. The Relationship The Leptin Hormone, Obesity and Diabetes. Physical Sciences. 2020;15(2):40-8.