THE EFFECTS OF THIOSEMICARBAZONE DERIVATIVE SCHIFF BASE 1-(1-PHENIL-1-METHYLCYCLOBUTANE-3-YL)-2-SUKSINIMIDO ETANON THIOSEMICARBAZONE ON ANTIOXIDAN VITAMINS IN LIVER, KIDNEY AND SERUM OF RABBITS
Abstract
Thiosemicarbazones
(TSC) are a class of compounds very promising in the treatment of many
diseases, cancer in particular, and its development is still in progress. The purpose of
the present study was to evaluate the effect of 1-(1-phenil-1-methylcyclobutane-3-yl)-2-suksinimido
etanonthiosemicarbazone (FSTSC) on antioxidan vitamins (A,
E, C) in liver, kidney and serum of rabbits. Twenty male rabbits were randomly divided into two groups. The
first group was used as a control which injected
subcutaneously
of 250µl, 10% dimethylsulphoxide was given to the control group every otherday.
FSTSC compound (25mgkg–1, dissolved in 250µl, 10%
dimethylsulphoxide) was administered to the other group of rabbits.This
administration was done for a period of 32days.The vitamin levels (A, E and C) were
determined by high performance liquid chromatography (HPLC). The liver tissue and
serum vitamin C levels were significantly decreased compared to control group
(P<0.05). Levels of vitamins A in kidney was significantly decreased
compared to control group (P<0.05). In addition to many pharmacological
properties of the TSC derivatives examined, it will contribute to the knowledge
of the literature.
Keywords
Thiosemicarbazone Antioxidants Liver Kidney Serum Rabbit HPLC HPLC
References
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Abstract
References
- 1. Liberta, A.E. and West, D.X., (1992). Antifungal and Antitumour Activity of Heterocyclic Thiosemicarbazones and Their Metal Complexes. Biometals 5:121–126.
- 2. Padhy, S. and Kauffman, G.B., (1985). Transition Metal Complexes of Semicarbazones and Thiosemicarbazones. Coord ChemRev 63:127–160.
- 3. Richardson, D.R., (2002). Iron Chelators as Therapeutic Agents for the Treatment of Cancer, Crit. Rev. Oncol. Hematol. 42:267–281.
- 4. Belicchi-Ferrari, M., Isceglie, F., Casoli, C., Durot, S., Morgenstern-Badarau, I., Pelosi, G., Pilotti, E., Pinelli, S., and Tarasconi, P., (2005). Copper (II) and Co-balt (III) Pyridoxalthiosemicarbazone Complexes with Nitroprusside as Counterion: Syntheses, Electronic Properties, and Antileukemic Activity, J. Med. Chem. 48:1671–1675.
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- 7. Shih, M.H. and Ke, F.Y., (2004). Syntheses and Evaluation of Antioxidant Activity of Sydnonyl Substituted Thiazolidinone and Thiazoline Derivatives. Bioorg Med Chem. Sep 17:4633-43.
- 8. Moon, R.C., McCormick, D.L., and Mehta, R.G., (1983). Inhibition of Carcinogenesis by Retinoids, Cancer Res. 43:2469-2475.
- 9. Laila G, Yues A, Bernard H, Claude J, Gerard C, Gerard S (1991) Biological variability of superoxide dismutase glutathione peroxidase and catalase in blood, Clin. Chem. 37:1932-1937.
- 10. Halliwell, B., (1994). Free Radical Antioxidants in Human Disease. Curiosity, cause or consequence, Lancet. 344:721-724.
- 11. Cukurovali, A. and Yilmaz, I., (2000). Synthesis and Characterization of a Newcyclobutane Substituted Schiff Base Ligand and its Cd(II), Co(II), Ni(II) and Zn(II) complexes. Polish J Chem 74:147–151.
- 12. Miller, K.W., Lorr, N.A., and Yang, C.S., (1984). Simultaneous Determination of Plasma Retinol, á -tocopherol, lycopene, á -carotene, and â -carotene by high performance liquid- chromatography, Anal. Biochem. 138:340–345.
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- 14. Tavazzi, B., Lazzarino, G., Di-Piero, D., and Giardina, B., (1992). Malondialdehyde Production and Ascorbate Decrease are Associated to the Reperfusion of the Isolated Postischemic Rat Heart, Free Radic. Biol. Med. 13:75–78.
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- 19. Maramag, C., Menon, M., Balaji, K.C., Reddy, P.G., and Laxmanan, S., (1997). Effect of Vitamin C on Prostate Cancer Cells in vitro: Effect on Cell Number, via-bility, and DNA synthesis, Prostate 32:188–195.
- 20. Niki, E., (1991). Vitamin C as an Antioxidant, World. Rew. Nutr. Diet, 64:3-30.
- 21. Sogawa, S., Nihro, Y., Ueda, H., Miki, T., Matsomota, H., and Satoh, T., (1994). Protec-tive Effects of Hydroxychalcones on Free Radical-Induced Cell Damage, Biol. Pharm. Bull. 17:251–256.
Details
| Subjects | Engineering |
|---|---|
| Journal Section | Chemistry |
| Authors | |
| Publication Date | January 20, 2018 |
| Published in Issue | Year 2018 Volume: 13 Issue: 1 |