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THE ANALYSIS OF FATTY ACİDS LEVEL IN RAT HEARTH TISSUES PERFORMED MYOCARDIAL ISCHEMIA-REPERFUSION INJURY AND MELATONIN

Year 2016, Volume: 11 Issue: 2, 17 - 24, 11.04.2016

Aysel Sarı

Abstract

Melatonin (N-acetyl-5-methoxytryptamine),the main secretory product of the pineal gland, is a free radical scavenger that has been found to protect against lipid peroxidation in many experimental models. In the present many study the effect of melatonin on lipid peroxidation of long chain polyunsaturated fatty acids located in rat. The most sensitive fatty acids in the heart were the monounsaturated eicosenoik acid (C20:1 n-6), polyunsaturated arachidonic acid (C20:4 n-6) docosapenthonoic acid (C22:5 n-3) and docosahexanoic acid (C22:6 n-3) which compared with the corresponding control values. I/R performed group showed remarkable differerences (p<0.05).In this study, myokardial-iscemia reperfusion is determined to cause increase or decreasa in different types of fatty acids.

Keywords

Melatonin Myocardial Ischemia-Reperfusion Tissues Fatty acids Gas Chromatography

References

  • • Reiter, R.J., Tan, D.X., Mayo, J.C., and et al., (2003). Melatonin as an antioxidant: Biochemical Mechanisms and Patho Physiological Implications in Humans. Acta Biochim Pol, 50:1129-46.
  • • Tang, P.L., Xu, M.F., and Qian, Z.M., (1997). Dierential behaviour of cell membranes towards iron-induced oxidative damage and the effects of melatonin. Biol Signals, 6:291–300.
  • • Allegra, M., Reiter, R.J., Tan, D.X., and et al., (2003). The chemistry of melatonin ’s interaction with reactive species. J, Pineal Res, 34:1–10.
  • • Sahna, E., Deniz, E., and Aksulu, H.E., (2006). Myocardial ischemia-reperfusion injury and melatonin. Anadolu,Jun, 6(2):163-8.
  • • Deniz, E., Colakoglu, N., Sari, A., Sonmez, M.F., Tugrul, I., Oktar, S., Ilhan, S., and Sahna, E., (2006). Melatonin attenuates renal ischemia-reperfusion injury in nitric oxide synthase inhibited rats. Acta Histochem, 108(4):303-9. Epub Jun 9.
  • • Bang, H.O., Dyerberg, J., and Nielsen, A.B., (1971). Plasma lipid and lipoprotein pattern in Greenlandic West-coast Eskimos. Lancet 1:1143–1145.
  • • Bang, H.O., and Dyerberg, J., (1981). Personal reflections on the incidence of ischaemic heart disease in Oslo during the Sec-ond World War. Acta Med. Scand. 210:245–248.
  • • Hodgson, J., Wahlqvist, M., Boxall, J., and Balazs, N., (1993). Can linoleic acid contribute to coronary artery disease? Am. J. Clin. Nutr. 58:228–234.
  • • Osler, M., Godtfredsen, J., Gronbaek, M.N., Marckmann, P., and Overvad, O.K., (2000). A quantitative assessment of the impact of diet on the mortality of heart disease in Denmark. Estima- tion of etiologic fraction. Uges. Laeger 162:4921–4925.
  • • Keys, A., Menotti, A., Karvonen, M., Aravanis, C., Blackburn, H., Buzina, R., and et al., (1986). The diet and 15-year death rate in the seven countries study. Am. J. Epidemiol. 124:903–915.
  • • Oomen, C.M., Feskens, E.J., Rasanen, L., Fidanza, F., Nissinen, A.M., Menotti, A., and et al., (2000). Fish consumption and coronary heart disease mortality in Finland, Italy, and The Netherlands. Am. J. Epidemiol. 151:999–1006.
  • • Marckmann, P., and Gronbaek, M., (1999). Fish consumption and coronary heart disease mortality. A systematic review of prospective cohort studies. Eur. J. Clin. Nutr. 53:585–590.
  • • Bang, H.O., Dyerberg, J., and Hjoorne, N., (1976). The composition of food consumed by Greenland Eskimos, Acta Med. Scand. 200:69–73.
  • • Endo, A., Kuroda, M., and Tanzawa, K., (1976). Competitive inhibition of 3- HMGCoA reductase by ML 236 A and ML 236 B, FEBS Lett. 72:323–326.
  • • Singh, R.B., Dubnov, G., NIaz, M.A., and et al., (2002). Effect of an Indo Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomised single-blind trial, Lancet 360, 1455–1461.
  • • Kappus, H.A., (1987). A survey of chemicals inducing lipid peroxidation in biological systems. Chem. Phys. Lipids. 45:105–15.
  • • Fang, J.L., Vaca, C.E., Valsta, L.M., and Mutanen, M., (1996). Determination of DNA adducts of malonaldehyde in humans: effects of dietary fatty acid composition. Carcinogenesis 17:1035-1040.
  • • Sarkar, S., Yadav, P., and Bhatnagar, D.J., (1997). Cadmium-induced lipid peroxidation and the antioxidant system in raterythrocytes: the role of antioxidants. Trace Elem. Med. Biol 11:8-13.
  • • Cheesman, K.H., and Slater, T.F., (1993). Introduction to free radical biochemistry. Br. Med. Bull. 49:481-493.
  • • Garcia, J.J., Reiter, R.J., Guerrero, J.M., and et al., (1997). Melatonin prevents changes in microsomal membrane. uidity during induced lipid peroxidation. FEBS Lett, 408:297–300.
  • • Rudzite, V., Jurika, E., and Jirgensons, J., (1999). Changes in membrane fluidity induced by tryptophan and its metabolites. Adv Exp Med Biol, 467:353–367.
  • • Leaden, P., Barrionuevo, J., and Catala, A., (2002). The protection of long chain polyunsaturated fatty acids by melatonin during non enzymatic lipid peroxidation of rat liver microsomes. J Pineal Res 32:129–134
  • • Gavazza, M.B., and Catala, A., (2004). Protective effect of Nacetyl-serotonin on the non enzymatic lipid peroxidation in rat testicular microsomes and mitochondria. J Pineal Res, 37:153–160.
  • • Sampath, H., and Ntambi, J.M., (2004). Polyunsaturated fatty acid regulation of gene expression. Nut Rev 2004; 62:333–339.
  • • Garcia, J.J., Reiter, R.J., Guerrero, J.M., Escames, G., Yu, B.P., Oh, C.S., and Munoz-Hoyos, A., (1997). Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation. FEBS Lett. 408:297–300.
  • • Longoni, B., Salgo, M.G., Pryor, W.A., and Marchiafava, P.L., (1998). Effects of melatonin on lipid peroxidation induced by oxygen radicals. Life Sci, 62:853–859.
  • • Sahna, E., Parlakpinar, H., Turkoz, Y., and Acet, A., (2005). Effects of melatonin on myocardial ischemiareperfusion-induced infarct size and oxidative stress. Physiol Res, 54:491–495.
  • • Christie, W.W., (1990). Gas Chromatography and Lipids, The Oil Press, Glasgow, 302-320.
  • • Folch, W., Robert, P., Lees, M., and Sladane-Stanly, G.H.A., (1957). Simple Metod for The Isolation and Prufication of Total Lipids from Animals Tissue, J. Biol. Chem., 226, 447-509.
  • • Peter, S., (1973). Extraction and Purification of Lipids, II Why is Chlorofrom-Metanol Such Good Lipid Solvent, Physiol. Chem. And Physic. 5, 141-149.
  • • Kohen, R., and Nyska, A., (2002). Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantication. Toxicol Pathol, 30:620–650.
  • • Porter, N.A., (1984). Chemistry of lipid peroxidation. Methods Enzymol, 105:273–282.
  • • Karbownik, M., Reiter, R.J., Burkhardt, S., and et al., (2001). Melatonin attenuates estradiol-induced oxidative damage to DNA: relevance for cancer prevention. Exp Biol Med, 226:707–712.
  • • Tan, D.X., Chen, L.D., Poeggeler, B., and et al., (1993). Melatonin: a potent, endogenous hydroxyl radical scavenger. Endocrine J, 1:57–60.
  • • Leaden, P., Barrionuevo, J., and Catala, A., (2002). The protection of long chain polyunsaturated fatty acids by melatonin during non enzymatic lipid peroxidation of rat liver microsomes. J Pineal Res, 32:129–134.
  • • Gavazza, M.B., and Catala, A., (2004). Protective ect of N-acetyl-serotonin on the non enzymatic lipid peroxidation in rat testicular microsomes and mitochondria. J Pineal Res, 37:153–160.
  • • Patricio, J., Leaden and Angel Catala´., (2005). Protective effect of melatonin on ascorbate-Fe2+ lipid peroxidation of polyunsaturated fatty acids in rat liver, kidney and brain microsomes: a chemiluminescence study J. Pineal Res. 39:164–169.
  • • Subramanian, P., Mirunalini, S., Seithikurippu, R., Pandi-Perumal., and Ilya Trakht , D.P., (2007).Cardinali Melatonin treatment improves the antioxidant status and decreases lipid content in brain and liver of rats, European Journal of Pharmacology 571:116 –119.
  • • Tunez, L., Munoz, M.C., Feijoo-Lopez, A.L., Valdvira, E., Bujalance-Arenas, L., and Montilla, P., (2002). Effect of melatonin on hyperlipidemic nephropathy under constant light exposure. J. Physiol. Biochem. 58:109–114.
  • • Hoyos, M., Guerrero, J.M., Perez-Cano, R., Olivan, J., Fabiani, F., Garcia-Perganeda, A., and Osuna, C., (2000). Serum cholesterol and lipid peroxidation are decreased by melatonin in diet-induced hypercholesterolemic rats. J. Pineal Res. 28, 150–155.
  • • Das, U.N., (1995). Essential fatty acid metabolism in patients with essential hypertension, diabetes mellitus and coronary heart disease. Prostaglandins Leukot Essent Fatty Acids. Jun, 52(6):387-91.

SIÇANLARIN KALP DOKULARINDA YAĞ ASİTLERİ DÜZEYLERİNİN I/R VE MELATONİN UYGULAMALARIYLA DEĞİŞİMLERİNİN İNCELENMESİ

Year 2016, Volume: 11 Issue: 2, 17 - 24, 11.04.2016

Aysel Sarı

Abstract

Melatonin- beyin epifizinin ana ürünü olan salgısı-birçok deneyde yağ peroksidasyonuna karşı savaşan serbest radikal bir temizleyici olduğu gözlemlendi. Mevcut birçok çalışmalarda-farede yapılan-melatoninin çoklu doymamış yağ asitlerine etkisi olduğu belirlendi. Araşidonik asit (C20:4 n-6) dokosapentaenoik asit (C22:5 n-3, tekli doymamış yağ asitleri, eicosenoik asit (C20:1 n-6)ve dokosaheksaenoik asit (C22:6 n-3) karşılık gelen kontrol değeri ile karşılaştırıldı. I/R çalışılan grup büyük farklılıklar gösterdi. Bu çalışmada miyokardiyal iskemi reperfüzyonunun farklı yağ asitleri türlerinde artmalara veya azalmalara sebep olduğu belirlendi

Keywords

Melatonin Miyokardiyal İskemi Reperfüzyon

References

  • • Reiter, R.J., Tan, D.X., Mayo, J.C., and et al., (2003). Melatonin as an antioxidant: Biochemical Mechanisms and Patho Physiological Implications in Humans. Acta Biochim Pol, 50:1129-46.
  • • Tang, P.L., Xu, M.F., and Qian, Z.M., (1997). Dierential behaviour of cell membranes towards iron-induced oxidative damage and the effects of melatonin. Biol Signals, 6:291–300.
  • • Allegra, M., Reiter, R.J., Tan, D.X., and et al., (2003). The chemistry of melatonin ’s interaction with reactive species. J, Pineal Res, 34:1–10.
  • • Sahna, E., Deniz, E., and Aksulu, H.E., (2006). Myocardial ischemia-reperfusion injury and melatonin. Anadolu,Jun, 6(2):163-8.
  • • Deniz, E., Colakoglu, N., Sari, A., Sonmez, M.F., Tugrul, I., Oktar, S., Ilhan, S., and Sahna, E., (2006). Melatonin attenuates renal ischemia-reperfusion injury in nitric oxide synthase inhibited rats. Acta Histochem, 108(4):303-9. Epub Jun 9.
  • • Bang, H.O., Dyerberg, J., and Nielsen, A.B., (1971). Plasma lipid and lipoprotein pattern in Greenlandic West-coast Eskimos. Lancet 1:1143–1145.
  • • Bang, H.O., and Dyerberg, J., (1981). Personal reflections on the incidence of ischaemic heart disease in Oslo during the Sec-ond World War. Acta Med. Scand. 210:245–248.
  • • Hodgson, J., Wahlqvist, M., Boxall, J., and Balazs, N., (1993). Can linoleic acid contribute to coronary artery disease? Am. J. Clin. Nutr. 58:228–234.
  • • Osler, M., Godtfredsen, J., Gronbaek, M.N., Marckmann, P., and Overvad, O.K., (2000). A quantitative assessment of the impact of diet on the mortality of heart disease in Denmark. Estima- tion of etiologic fraction. Uges. Laeger 162:4921–4925.
  • • Keys, A., Menotti, A., Karvonen, M., Aravanis, C., Blackburn, H., Buzina, R., and et al., (1986). The diet and 15-year death rate in the seven countries study. Am. J. Epidemiol. 124:903–915.
  • • Oomen, C.M., Feskens, E.J., Rasanen, L., Fidanza, F., Nissinen, A.M., Menotti, A., and et al., (2000). Fish consumption and coronary heart disease mortality in Finland, Italy, and The Netherlands. Am. J. Epidemiol. 151:999–1006.
  • • Marckmann, P., and Gronbaek, M., (1999). Fish consumption and coronary heart disease mortality. A systematic review of prospective cohort studies. Eur. J. Clin. Nutr. 53:585–590.
  • • Bang, H.O., Dyerberg, J., and Hjoorne, N., (1976). The composition of food consumed by Greenland Eskimos, Acta Med. Scand. 200:69–73.
  • • Endo, A., Kuroda, M., and Tanzawa, K., (1976). Competitive inhibition of 3- HMGCoA reductase by ML 236 A and ML 236 B, FEBS Lett. 72:323–326.
  • • Singh, R.B., Dubnov, G., NIaz, M.A., and et al., (2002). Effect of an Indo Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomised single-blind trial, Lancet 360, 1455–1461.
  • • Kappus, H.A., (1987). A survey of chemicals inducing lipid peroxidation in biological systems. Chem. Phys. Lipids. 45:105–15.
  • • Fang, J.L., Vaca, C.E., Valsta, L.M., and Mutanen, M., (1996). Determination of DNA adducts of malonaldehyde in humans: effects of dietary fatty acid composition. Carcinogenesis 17:1035-1040.
  • • Sarkar, S., Yadav, P., and Bhatnagar, D.J., (1997). Cadmium-induced lipid peroxidation and the antioxidant system in raterythrocytes: the role of antioxidants. Trace Elem. Med. Biol 11:8-13.
  • • Cheesman, K.H., and Slater, T.F., (1993). Introduction to free radical biochemistry. Br. Med. Bull. 49:481-493.
  • • Garcia, J.J., Reiter, R.J., Guerrero, J.M., and et al., (1997). Melatonin prevents changes in microsomal membrane. uidity during induced lipid peroxidation. FEBS Lett, 408:297–300.
  • • Rudzite, V., Jurika, E., and Jirgensons, J., (1999). Changes in membrane fluidity induced by tryptophan and its metabolites. Adv Exp Med Biol, 467:353–367.
  • • Leaden, P., Barrionuevo, J., and Catala, A., (2002). The protection of long chain polyunsaturated fatty acids by melatonin during non enzymatic lipid peroxidation of rat liver microsomes. J Pineal Res 32:129–134
  • • Gavazza, M.B., and Catala, A., (2004). Protective effect of Nacetyl-serotonin on the non enzymatic lipid peroxidation in rat testicular microsomes and mitochondria. J Pineal Res, 37:153–160.
  • • Sampath, H., and Ntambi, J.M., (2004). Polyunsaturated fatty acid regulation of gene expression. Nut Rev 2004; 62:333–339.
  • • Garcia, J.J., Reiter, R.J., Guerrero, J.M., Escames, G., Yu, B.P., Oh, C.S., and Munoz-Hoyos, A., (1997). Melatonin prevents changes in microsomal membrane fluidity during induced lipid peroxidation. FEBS Lett. 408:297–300.
  • • Longoni, B., Salgo, M.G., Pryor, W.A., and Marchiafava, P.L., (1998). Effects of melatonin on lipid peroxidation induced by oxygen radicals. Life Sci, 62:853–859.
  • • Sahna, E., Parlakpinar, H., Turkoz, Y., and Acet, A., (2005). Effects of melatonin on myocardial ischemiareperfusion-induced infarct size and oxidative stress. Physiol Res, 54:491–495.
  • • Christie, W.W., (1990). Gas Chromatography and Lipids, The Oil Press, Glasgow, 302-320.
  • • Folch, W., Robert, P., Lees, M., and Sladane-Stanly, G.H.A., (1957). Simple Metod for The Isolation and Prufication of Total Lipids from Animals Tissue, J. Biol. Chem., 226, 447-509.
  • • Peter, S., (1973). Extraction and Purification of Lipids, II Why is Chlorofrom-Metanol Such Good Lipid Solvent, Physiol. Chem. And Physic. 5, 141-149.
  • • Kohen, R., and Nyska, A., (2002). Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantication. Toxicol Pathol, 30:620–650.
  • • Porter, N.A., (1984). Chemistry of lipid peroxidation. Methods Enzymol, 105:273–282.
  • • Karbownik, M., Reiter, R.J., Burkhardt, S., and et al., (2001). Melatonin attenuates estradiol-induced oxidative damage to DNA: relevance for cancer prevention. Exp Biol Med, 226:707–712.
  • • Tan, D.X., Chen, L.D., Poeggeler, B., and et al., (1993). Melatonin: a potent, endogenous hydroxyl radical scavenger. Endocrine J, 1:57–60.
  • • Leaden, P., Barrionuevo, J., and Catala, A., (2002). The protection of long chain polyunsaturated fatty acids by melatonin during non enzymatic lipid peroxidation of rat liver microsomes. J Pineal Res, 32:129–134.
  • • Gavazza, M.B., and Catala, A., (2004). Protective ect of N-acetyl-serotonin on the non enzymatic lipid peroxidation in rat testicular microsomes and mitochondria. J Pineal Res, 37:153–160.
  • • Patricio, J., Leaden and Angel Catala´., (2005). Protective effect of melatonin on ascorbate-Fe2+ lipid peroxidation of polyunsaturated fatty acids in rat liver, kidney and brain microsomes: a chemiluminescence study J. Pineal Res. 39:164–169.
  • • Subramanian, P., Mirunalini, S., Seithikurippu, R., Pandi-Perumal., and Ilya Trakht , D.P., (2007).Cardinali Melatonin treatment improves the antioxidant status and decreases lipid content in brain and liver of rats, European Journal of Pharmacology 571:116 –119.
  • • Tunez, L., Munoz, M.C., Feijoo-Lopez, A.L., Valdvira, E., Bujalance-Arenas, L., and Montilla, P., (2002). Effect of melatonin on hyperlipidemic nephropathy under constant light exposure. J. Physiol. Biochem. 58:109–114.
  • • Hoyos, M., Guerrero, J.M., Perez-Cano, R., Olivan, J., Fabiani, F., Garcia-Perganeda, A., and Osuna, C., (2000). Serum cholesterol and lipid peroxidation are decreased by melatonin in diet-induced hypercholesterolemic rats. J. Pineal Res. 28, 150–155.
  • • Das, U.N., (1995). Essential fatty acid metabolism in patients with essential hypertension, diabetes mellitus and coronary heart disease. Prostaglandins Leukot Essent Fatty Acids. Jun, 52(6):387-91.
There are 41 citations in total.

Details

Primary Language English
Journal Section Chemistry
Authors

Aysel Sarı

Publication Date April 11, 2016
Published in Issue Year 2016 Volume: 11 Issue: 2

Cite

APA Sarı, A. (2016). THE ANALYSIS OF FATTY ACİDS LEVEL IN RAT HEARTH TISSUES PERFORMED MYOCARDIAL ISCHEMIA-REPERFUSION INJURY AND MELATONIN. Physical Sciences, 11(2), 17-24.
AMA Sarı A. THE ANALYSIS OF FATTY ACİDS LEVEL IN RAT HEARTH TISSUES PERFORMED MYOCARDIAL ISCHEMIA-REPERFUSION INJURY AND MELATONIN. Physical Sciences. April 2016;11(2):17-24.
Chicago Sarı, Aysel. “THE ANALYSIS OF FATTY ACİDS LEVEL IN RAT HEARTH TISSUES PERFORMED MYOCARDIAL ISCHEMIA-REPERFUSION INJURY AND MELATONIN”. Physical Sciences 11, no. 2 (April 2016): 17-24.
EndNote Sarı A (April 1, 2016) THE ANALYSIS OF FATTY ACİDS LEVEL IN RAT HEARTH TISSUES PERFORMED MYOCARDIAL ISCHEMIA-REPERFUSION INJURY AND MELATONIN. Physical Sciences 11 2 17–24.
IEEE A. Sarı, “THE ANALYSIS OF FATTY ACİDS LEVEL IN RAT HEARTH TISSUES PERFORMED MYOCARDIAL ISCHEMIA-REPERFUSION INJURY AND MELATONIN”, Physical Sciences, vol. 11, no. 2, pp. 17–24, 2016.
ISNAD Sarı, Aysel. “THE ANALYSIS OF FATTY ACİDS LEVEL IN RAT HEARTH TISSUES PERFORMED MYOCARDIAL ISCHEMIA-REPERFUSION INJURY AND MELATONIN”. Physical Sciences 11/2 (April 2016), 17-24.
JAMA Sarı A. THE ANALYSIS OF FATTY ACİDS LEVEL IN RAT HEARTH TISSUES PERFORMED MYOCARDIAL ISCHEMIA-REPERFUSION INJURY AND MELATONIN. Physical Sciences. 2016;11:17–24.
MLA Sarı, Aysel. “THE ANALYSIS OF FATTY ACİDS LEVEL IN RAT HEARTH TISSUES PERFORMED MYOCARDIAL ISCHEMIA-REPERFUSION INJURY AND MELATONIN”. Physical Sciences, vol. 11, no. 2, 2016, pp. 17-24.
Vancouver Sarı A. THE ANALYSIS OF FATTY ACİDS LEVEL IN RAT HEARTH TISSUES PERFORMED MYOCARDIAL ISCHEMIA-REPERFUSION INJURY AND MELATONIN. Physical Sciences. 2016;11(2):17-24.