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EVALUATION OF CHANGES IN SERUM LEVELS OF FATTY ACID IN NEWLY DIAGNOSED TYPE 2 DIABETIC PATIENTS

Year 2015, , 37 - 43, 21.04.2015

Aysel Sarı Mahmut Bozkurt İhsan Halıfeoglu

Abstract

In this study, the changes in levels of fatty acids betweennewly diagnosed type 2 diabetic patients and the control group were evealuated. In this study, 16:0, 16:1, 18:0 and 22:6 fatty acids levels of Type 2 diabetic group were found not to be statistically significant. The 18:2 fatty acid levels of Type 2 diabetic patients were lower than the control group and it was not found to be statistically significant. The 18:1 and 18:3 fatty acid levels of Type 2 diabetic patients were found to be statistically significantly lower (p<0.05) compared to the control group, the 20:3 and 20:4 fatty acid levels were found to be statistically significantly higher (p<0.001) compared to the control group.

Keywords

Newly Diagnosed Type 2 Diabetic Patients Serum Fatty acids Gas Chromatography Diabetic

References

  • Koloğlu, S., (1996). Diabetes Mellitus. In: Endokrinoloji. 1. Baskı, Koloğlu S.ed Medikal Network, 367–386.
  • MacFarlane, I.A., Bliss, M., Jackson, J.G.L., and Williams, G., (1997). The History of Diabetes Mellitus. In: Textbook of Diabetes. Volume 1. Second Edition. Pickup JC., Williams G., eds. Oxford: Blackwell Science Ltd. 1.1-1.21.
  • Wieland, D.M., Kotzka, J., and Goldstain, B.J., (2004). Tip 2 Diyabetin Patogenezi. Goldstain BJ, Wieland DM (editors). Cengiz Akman (Çeviri Editörü). Tip 2 Diyabet, 1.Baskı, İstanbul: And Danışmanlık Yayıncılık, 13–25.
  • Cefalu, W.T., (2001). İnsülin Resistance: Cellular and Clinical Concepts. Exp Biol Med, 226, ss:13–26.
  • Orhan, Y., (2001). Diabetes Mellitus. In: Endokrinoloji, Metabolizma ve Beslenme Hastalıkları, ed. Sencer E, Nobel, İstanbul, ss:246–86.
  • Laakso, M., (2003). Tip 2 Diyabetin Patogenezi. In: Tip 2 Diyabet, ed. Goldstein BJ, Wieland DM, AND, İstanbul, pp.13–28.
  • Candeğer, Y., Temel, Y., ve Imamoğlu, A., (2000). Tip 2 Diyabet Patogenezi, Klinik Özellikleri ve İzleme Ölçütleri. In: Diabetes Mellitus, Ed:, Gri Tasarım, pp:37-46.
  • Hornstra, G., (1992). Effect of n–3 Fatty Acids on Eicosanoid Formation, İmplication for Platelrt Thrombotic Function. Agents Actions.37.145.
  • Myrup, B., 1991). Platelet Aggregation and Fatty Acids Composition of Platelets in Type I Diabetes Mellitus. Clin Chim Acta 204 (1-3): 251.
  • Axelord, L., (1988). Omega 3 Fatty Acids in Diabetes Mellitus. Circulation 70 (Supp II):288.
  • Matthews, D., Hosker, J., Rudenski, A., Naylor, B., Treacher, D., and Turner, R., (1985). Homeostasis Model Assassment: İnsulin Resistance and Beta Cell Function from Plasma Glucose and İnsulin Concentration in Man. Diabetologia; 28: 412–419.
  • Hara, A. and Radin, N.S., (1978). Lipid Extraction of Tissues with a Low-Toxicity Solvent, Analitical Biochemistry 90,420-426.
  • Christie, W.W., (1992). Gas chromatography and Lipids, The Oil Pres Glaskow, 302.
  • Mitrakou, A., Kelley, D., Mokan, M., Veneman, T., Pagburn, T., Reilly, J., and Gerich, J., (1992). J.Role of Reduced Suppression of Glucose Production and Diminished Early İnsulin Release İn İmpaired Glucose Tolerance. N Engl J Med. 326:22–29.
  • Ludvic, B., Nolan, J.J., Baloga, J., Sacks, D., and Olefsky, J., (1995). Effect of Obesity on İnsulin Resistance in Normal Subject and Patients with NIDDM. Diabetes 44: 1121–1125.
  • Vendrell, J., Broch, M., Vilarrasa, N., Molina, A., Gomez, J.M., Gutierrez, C., Simon, I., Soler, J., and Richart, C., (2004). Resistin, Adiponectin, Ghrelin, Leptin, and Proinflammatory Cytokines: Relationships in Obesity. Obes Res.12(6):962–71.
  • Silha, J.V., Krsek, M., Skrha, J., Sucharda, P., Nyomba, B.L., and Murphy, L.J., (2003). Plasma Resistin, Leptin and Adiponectin Levels in Lean and Obese Subjects: Correlations with İnsulin Resistance. Eur J Endocrinol. 149(4):331–5.
  • Kern, P.A., Subramanian, R., Chunling, L.I., Linda, W,, and Gouri, R., (2001). Adipose Tissue Tumor Necrosis Factor and İnterlleukin–6 Expression in Human Obesity and İnsulin Resistance. Am J Physiol Endocrinol Metab 280: E745-E751.
  • Kopelman, P.G. and Stock, M.J., (1998). Clinical Obesity, pp:311–348.
  • Frayn, K.N., Williams, C.M., and Arner, P., (1996). Are İncreased Plasma Non-Esterified Fatty Acid Concentrations A Risk Marker for Coronary Heart Disease and Other Chronic Diseases. Clinical Sciense 90, 243–253.
  • Boden, G., (1997.) Role of Fatty Acids in the Pathogenesis of İnsulin Resistance and NIDDM. Diabetes 46, 3–10.
  • Randle, P.J., Garland, P.B., Hales, C.N., and Newsholme, C.A., (1963). The glucose fatty acids cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1, 785–789.
  • Abate, N., Garg, A., Peshock, RM., and ets., (1996). Relationship of Generalized and Regional Adiposity to İnsulin Sensitivity in Men with NIDDM. Diabetes 45, 1684–1693.
  • Horrobin, D.F., (1989). Essential Fatty Acids and the Complications of Diabetes Mellitus. Wiener Klinische Woechenschrift. 101(8):289.
  • Malasamos, T.H., (1991). Biolological of n–3 Fatty Acids in Diabetes Mellitus. Diabetes Care 14(12):1160.
  • Mimouni, V., (1992). Spontaneous Diabetes in Bio-Brerding Rats: Evidence for İnsulin Dependent Liver Microsomal Delta–9 Stearic Acid Desaturation. Diabete Metab. 18(2): 91.
  • Miettinen, T.A. and Tilvis, R.S., (1981). Effect of Fish Oil on Serum Lipids and Fatty Acids of Red Cells and Platelets in Type Diabetes Mellitus. Circulation 70(supp II).
  • Tilvis, R.S. and Miettinen, T.A, (1985). Fatty Acids Composotions Serum Lipids Erythrocytes and Plateletes in Type II Diabetec Women. J.Clin Endocr Metab. 61(4): 741.
  • Janes, D.B. and Carter, R.D., (1983). Low Phospholipid Arachidonic Acid Valves in Diabetic Plateletes Br. Med. J 286:173.
  • Tilvis, R.S and Taskinem, M., (1988). Effect of İnsulin Treatment on Fatty Acids of Plasma and Erythrocyte Membrane Lipids in Type 2 Diabetes. Clin Chim Acta 171:293.
  • Colwel, J., Wincour, P., Lopes-Virella, M., and Haluska, P., (1983). New Concepts about The Pathogenesis of Atherosclerosis in Diabetes Mellitus. Am. J. Med.75: pp.67-80.
  • Holman, R.T., Jhonsan, S.B., Gerrard, J.M., Mauer, S.M., Kupcho-Sandberg, S.M., and Brown., D.M., (1983). Aracihidonic Acid Deficiency in The Streptozotocin-İnduced Diabetes. Proc. Natl. Acad. Sci. USA 80, pp:2375-2379.

YENİ TANI KONMUŞ TİP 2 DİABETİK HASTALARDA SERUM YAĞ ASİTLERİ DÜZEYLERİNDEKİ DEĞİŞİMLERİN DEĞERLENDİRİLMESİ

Year 2015, , 37 - 43, 21.04.2015

Aysel Sarı Mahmut Bozkurt İhsan Halıfeoglu

Abstract

Bu çalışmada yeni tanı konmuş tip 2 diabetik hastalar ile kontrol grubu arasında yağ asitleri düzeylerindeki değişimleri değerlendirilmiştir. Yapılan çalışmada, Tip 2 diabetik grubunun 16:0, 16:1, 18:0 ve 22:6 yağ asitleri düzeyleri istatiksel olarak anlamsız bulunmuştur. Tip 2 diabetik hasta grubunun 18:2 yağ asitleri düzeyleri kontrol gurubuna daha göre düşük çıkmış ve istatiksel olarak anlamsız bulunmuştur. Diabetik hasta grubunun 18:1 ve 18:3 yağ asidi düzeyleri ise kontrol grubuna göre istatiksel olarak (p<0.05) anlamlı düşük bulunmuş, 20:3 ve 20:4 yağ asidi düzeyleri ise kontrol grubuna göre istatiksel olarak (p<0.001) anlamlı yüksek bulunmuştur

Keywords

Yeni Tanı Konmuş Tip 2 Diabetik Hastalar

References

  • Koloğlu, S., (1996). Diabetes Mellitus. In: Endokrinoloji. 1. Baskı, Koloğlu S.ed Medikal Network, 367–386.
  • MacFarlane, I.A., Bliss, M., Jackson, J.G.L., and Williams, G., (1997). The History of Diabetes Mellitus. In: Textbook of Diabetes. Volume 1. Second Edition. Pickup JC., Williams G., eds. Oxford: Blackwell Science Ltd. 1.1-1.21.
  • Wieland, D.M., Kotzka, J., and Goldstain, B.J., (2004). Tip 2 Diyabetin Patogenezi. Goldstain BJ, Wieland DM (editors). Cengiz Akman (Çeviri Editörü). Tip 2 Diyabet, 1.Baskı, İstanbul: And Danışmanlık Yayıncılık, 13–25.
  • Cefalu, W.T., (2001). İnsülin Resistance: Cellular and Clinical Concepts. Exp Biol Med, 226, ss:13–26.
  • Orhan, Y., (2001). Diabetes Mellitus. In: Endokrinoloji, Metabolizma ve Beslenme Hastalıkları, ed. Sencer E, Nobel, İstanbul, ss:246–86.
  • Laakso, M., (2003). Tip 2 Diyabetin Patogenezi. In: Tip 2 Diyabet, ed. Goldstein BJ, Wieland DM, AND, İstanbul, pp.13–28.
  • Candeğer, Y., Temel, Y., ve Imamoğlu, A., (2000). Tip 2 Diyabet Patogenezi, Klinik Özellikleri ve İzleme Ölçütleri. In: Diabetes Mellitus, Ed:, Gri Tasarım, pp:37-46.
  • Hornstra, G., (1992). Effect of n–3 Fatty Acids on Eicosanoid Formation, İmplication for Platelrt Thrombotic Function. Agents Actions.37.145.
  • Myrup, B., 1991). Platelet Aggregation and Fatty Acids Composition of Platelets in Type I Diabetes Mellitus. Clin Chim Acta 204 (1-3): 251.
  • Axelord, L., (1988). Omega 3 Fatty Acids in Diabetes Mellitus. Circulation 70 (Supp II):288.
  • Matthews, D., Hosker, J., Rudenski, A., Naylor, B., Treacher, D., and Turner, R., (1985). Homeostasis Model Assassment: İnsulin Resistance and Beta Cell Function from Plasma Glucose and İnsulin Concentration in Man. Diabetologia; 28: 412–419.
  • Hara, A. and Radin, N.S., (1978). Lipid Extraction of Tissues with a Low-Toxicity Solvent, Analitical Biochemistry 90,420-426.
  • Christie, W.W., (1992). Gas chromatography and Lipids, The Oil Pres Glaskow, 302.
  • Mitrakou, A., Kelley, D., Mokan, M., Veneman, T., Pagburn, T., Reilly, J., and Gerich, J., (1992). J.Role of Reduced Suppression of Glucose Production and Diminished Early İnsulin Release İn İmpaired Glucose Tolerance. N Engl J Med. 326:22–29.
  • Ludvic, B., Nolan, J.J., Baloga, J., Sacks, D., and Olefsky, J., (1995). Effect of Obesity on İnsulin Resistance in Normal Subject and Patients with NIDDM. Diabetes 44: 1121–1125.
  • Vendrell, J., Broch, M., Vilarrasa, N., Molina, A., Gomez, J.M., Gutierrez, C., Simon, I., Soler, J., and Richart, C., (2004). Resistin, Adiponectin, Ghrelin, Leptin, and Proinflammatory Cytokines: Relationships in Obesity. Obes Res.12(6):962–71.
  • Silha, J.V., Krsek, M., Skrha, J., Sucharda, P., Nyomba, B.L., and Murphy, L.J., (2003). Plasma Resistin, Leptin and Adiponectin Levels in Lean and Obese Subjects: Correlations with İnsulin Resistance. Eur J Endocrinol. 149(4):331–5.
  • Kern, P.A., Subramanian, R., Chunling, L.I., Linda, W,, and Gouri, R., (2001). Adipose Tissue Tumor Necrosis Factor and İnterlleukin–6 Expression in Human Obesity and İnsulin Resistance. Am J Physiol Endocrinol Metab 280: E745-E751.
  • Kopelman, P.G. and Stock, M.J., (1998). Clinical Obesity, pp:311–348.
  • Frayn, K.N., Williams, C.M., and Arner, P., (1996). Are İncreased Plasma Non-Esterified Fatty Acid Concentrations A Risk Marker for Coronary Heart Disease and Other Chronic Diseases. Clinical Sciense 90, 243–253.
  • Boden, G., (1997.) Role of Fatty Acids in the Pathogenesis of İnsulin Resistance and NIDDM. Diabetes 46, 3–10.
  • Randle, P.J., Garland, P.B., Hales, C.N., and Newsholme, C.A., (1963). The glucose fatty acids cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1, 785–789.
  • Abate, N., Garg, A., Peshock, RM., and ets., (1996). Relationship of Generalized and Regional Adiposity to İnsulin Sensitivity in Men with NIDDM. Diabetes 45, 1684–1693.
  • Horrobin, D.F., (1989). Essential Fatty Acids and the Complications of Diabetes Mellitus. Wiener Klinische Woechenschrift. 101(8):289.
  • Malasamos, T.H., (1991). Biolological of n–3 Fatty Acids in Diabetes Mellitus. Diabetes Care 14(12):1160.
  • Mimouni, V., (1992). Spontaneous Diabetes in Bio-Brerding Rats: Evidence for İnsulin Dependent Liver Microsomal Delta–9 Stearic Acid Desaturation. Diabete Metab. 18(2): 91.
  • Miettinen, T.A. and Tilvis, R.S., (1981). Effect of Fish Oil on Serum Lipids and Fatty Acids of Red Cells and Platelets in Type Diabetes Mellitus. Circulation 70(supp II).
  • Tilvis, R.S. and Miettinen, T.A, (1985). Fatty Acids Composotions Serum Lipids Erythrocytes and Plateletes in Type II Diabetec Women. J.Clin Endocr Metab. 61(4): 741.
  • Janes, D.B. and Carter, R.D., (1983). Low Phospholipid Arachidonic Acid Valves in Diabetic Plateletes Br. Med. J 286:173.
  • Tilvis, R.S and Taskinem, M., (1988). Effect of İnsulin Treatment on Fatty Acids of Plasma and Erythrocyte Membrane Lipids in Type 2 Diabetes. Clin Chim Acta 171:293.
  • Colwel, J., Wincour, P., Lopes-Virella, M., and Haluska, P., (1983). New Concepts about The Pathogenesis of Atherosclerosis in Diabetes Mellitus. Am. J. Med.75: pp.67-80.
  • Holman, R.T., Jhonsan, S.B., Gerrard, J.M., Mauer, S.M., Kupcho-Sandberg, S.M., and Brown., D.M., (1983). Aracihidonic Acid Deficiency in The Streptozotocin-İnduced Diabetes. Proc. Natl. Acad. Sci. USA 80, pp:2375-2379.
There are 32 citations in total.

Details

Primary Language English
Journal Section Chemistry
Authors

Aysel Sarı

Mahmut Bozkurt

İhsan Halıfeoglu This is me

Publication Date April 21, 2015
Published in Issue Year 2015

Cite

APA Sarı, A., Bozkurt, M., & Halıfeoglu, İ. (2015). EVALUATION OF CHANGES IN SERUM LEVELS OF FATTY ACID IN NEWLY DIAGNOSED TYPE 2 DIABETIC PATIENTS. Physical Sciences37-43. https://doi.org/10.12739/NWSA.2015.10.2.3A0071
AMA Sarı A, Bozkurt M, Halıfeoglu İ. EVALUATION OF CHANGES IN SERUM LEVELS OF FATTY ACID IN NEWLY DIAGNOSED TYPE 2 DIABETIC PATIENTS. Physical Sciences. Published online April 1, 2015:37-43. doi:10.12739/NWSA.2015.10.2.3A0071
Chicago Sarı, Aysel, Mahmut Bozkurt, and İhsan Halıfeoglu. “EVALUATION OF CHANGES IN SERUM LEVELS OF FATTY ACID IN NEWLY DIAGNOSED TYPE 2 DIABETIC PATIENTS”. Physical Sciences, April (April 2015), 37-43. https://doi.org/10.12739/NWSA.2015.10.2.3A0071.
EndNote Sarı A, Bozkurt M, Halıfeoglu İ (April 1, 2015) EVALUATION OF CHANGES IN SERUM LEVELS OF FATTY ACID IN NEWLY DIAGNOSED TYPE 2 DIABETIC PATIENTS. Physical Sciences 37–43.
IEEE A. Sarı, M. Bozkurt, and İ. Halıfeoglu, “EVALUATION OF CHANGES IN SERUM LEVELS OF FATTY ACID IN NEWLY DIAGNOSED TYPE 2 DIABETIC PATIENTS”, Physical Sciences, pp. 37–43, April 2015, doi: 10.12739/NWSA.2015.10.2.3A0071.
ISNAD Sarı, Aysel et al. “EVALUATION OF CHANGES IN SERUM LEVELS OF FATTY ACID IN NEWLY DIAGNOSED TYPE 2 DIABETIC PATIENTS”. Physical Sciences. April 2015. 37-43. https://doi.org/10.12739/NWSA.2015.10.2.3A0071.
JAMA Sarı A, Bozkurt M, Halıfeoglu İ. EVALUATION OF CHANGES IN SERUM LEVELS OF FATTY ACID IN NEWLY DIAGNOSED TYPE 2 DIABETIC PATIENTS. Physical Sciences. 2015;:37–43.
MLA Sarı, Aysel et al. “EVALUATION OF CHANGES IN SERUM LEVELS OF FATTY ACID IN NEWLY DIAGNOSED TYPE 2 DIABETIC PATIENTS”. Physical Sciences, 2015, pp. 37-43, doi:10.12739/NWSA.2015.10.2.3A0071.
Vancouver Sarı A, Bozkurt M, Halıfeoglu İ. EVALUATION OF CHANGES IN SERUM LEVELS OF FATTY ACID IN NEWLY DIAGNOSED TYPE 2 DIABETIC PATIENTS. Physical Sciences. 2015:37-43.