The usage of Epilobium
angustifolium L. in folk medicine against prostate and skin diseases encouraged
us to investigate pBR322 DNA-binding ability, biological activities and
chemical composition of wild growing Epilobium
angustifolium L.’s methanolic, ethanolic and aqueous extracts from
Canakkale, Turkey. DNA-binding activity was studied by agarose gel
electrophoresis and chemical composition via GC, GC-MS, HPLC, LC-MS, ICP-MS and
AAS. Literature survey indicates no data on pBR322 plasmid DNA interaction of Epilobium species which is an important
criteria for being a potential anticancer agent. Antibacterial and antifungal
effects were tested against 11 bacterias and 3 fungis and compared with
ampicillin, chloramphenicol and ketokanozol by agar well diffusion techniques. Total
phenolic content was found by Folin-Ciocalteu method and antioxidant activity
was obtained by DPPH and Fe (II)-FZ (ferric-ferrozine) methods. This plant is rich of flavonoids, hormones,
fatty and phenolic acids. Si, K,
Mg, P and Mn were the main inorganic elements. Epilobium angustifolium L. with its high DNA-binding activity and
rich chemical composition can be a good potential anticancer, antimicrobial and
antioxidant prodrug.
DNA-Binding activity pBR322 plasmid DNA-Binding Epilobium angustifolium L. extracts cancer therapeutic chemical analysis¬¬¬
Primary Language | English |
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Subjects | Engineering, Chemical Engineering |
Journal Section | Articles |
Authors | |
Publication Date | August 3, 2017 |
Submission Date | June 7, 2017 |
Acceptance Date | August 2, 2017 |
Published in Issue | Year 2017 Volume: 4 Issue: 3 |