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References
- Yaşar NF, Uylas MU, Baspinar M, et al. Evaluating the use of hematological parameters in staging hidradenitis suppurativa. Wounds. 2016;28(11):87-91.
- Ünal A. Evaluation of mean platelet volume and platelet count in patients with hidradenitis suppurativa. TURKDERM-Turk Arch Dermatol Venereol. 2021;55:189-192.
- Cartron A, Driscoll MS. Comorbities of hidradenitis suppurativa: A review of the literature. Int J Womens Dermatol. 2019;5(5):330-334
- Saunte DML, Jemec GBE. Hidradenitis suppurativa: advances in diagnosis and treatment. JAMA. 2017;318(20):2019-2032.
- Lapic I, Padoan A, Bozzato D, Plebani M. Erythrocyte sedimentation rate and C-reactive protein in acute inflammation. Am J Clin Pathol. 2020;153(1):14-29.
- Kutlu Ö. Effect of isotretinoin treatment on the inflammatory markers in patients with acne vulgaris: can monocyte/HDL be a new indicator for inflammatory activity of isotretinoin treatment? Cutan Ocul Toxicol. 2020;39(1):67-70.
- Gambichler T, Hessam S, Cramer P, Abu Rached N, Bechara FG. Complete blood collection-based systemic inflammation biomarkers for patients with hidradenitis suppurativa. J Eur Acad Dermatol Venereol. 2022;36(9):1593-1596.
- Demirbaş A, Elmas ÖF, Atasoy M, Türsen Ü, Lotti T. Can monocyte to HDL cholesterol ratio and monocyte to lymphocyte ratio be markers for inflammation and oxidative stress in patients with vitiligo? a preliminary study. Arch Dermatol Res. 2021;313(6):491-498.
- Metin N, Turan Ç. Increases in uric acid and monocyte-high-density lipoprotein ratio as possible atherosclerotic indicators in acne patients using isotretinoin. J Cosmet Dermatol. 2021;20(9):2945-2949.
- Çetinarslan T, Türel Ermertcan A, Özyurt B, Gündüz K. Evaluation of the laboratory parameters in hidradenitis suppurativa: can we use new inflammatory biomarkers? Dermatol Ther. 2021;34(2):e14835.
- Ekiz O, Balta I, Sen BB, et al. Mean platelet volume in recurrent aphthous stomatitis and Behçet disease. Angiology. 2014;65(2):161–165.
- Stefaniuk P, Szymczyk A, Podhorecka M. The Neutrophil to lymphocyte and lymphocyte to monocyte ratios as new prognostic factors in hematological malignancies - a narrative review. Cancer Manag Res. 2020;12:2961-2977.
- Öksüm Solak E, Baran Ketencioglu B, Cinar SL, Kartal D, Borlu M. The role of new inflammatory markers in determining disease activation and severity in patients with hidradenitis suppurativa. Int J Dermatol. 2023;62(8):1076-1081.
- Miller IM, Ring HC, Prens EP, et al. Leukocyte profile in peripheral blood and neutrophil-lymphocyte ratio in hidradenitis suppurativa: a comparative cross-sectional study of 462 cases. Dermatology. 2016;232(4):511-519.
- Kim DS, Lee J, Kim SH, Kim SM, Lee MG. Mean platelet volumeis elevated in patients with psoriasis vulgaris. Yonsei Med J. 2015;56(3):712-718.
- Kılıç S, Reşorlu H, Işik S, et al. Association between mean platelet volume and disease severity in patients with psoriasis and psoriatic arthritis. Postepy Dermatol Alergol. 2017;34(2):126-130.
- Sirin MC, Korkmaz S, Erturan I, et al. Evaluation of monocyte to HDL cholesterol ratio and other inflammatory markers in patients with psoriasis. An Bras Dermatol. 2020;95(5):575-582.
- Canpolat F, Akpınar H, Eskioglu F. Mean platelet volume in psoriasis and psoriatic arthritis. Clin Rheumatol. 2010;29(3):325–328.
- Ataş H, Canpolat F, Eskioglu F. Evaluation of mean platelet volume in patients with Behcet's disease as an indicator of vascular thrombosis. Arch Iran Med. 2018;21(6):234-239.
- Lippi G, Buonocore R, Cervellin G. The mean platelet volume is decreased in patients diagnosed with venous thromboembolism in the emergency department. Semin Thromb Hemost. 2016;42(6):632-635.
- Kanbay M, Solak Y, Unal HU, et al. Monocyte count/HDL cholesterol ratio and cardiovascular events in patients with chronic kidney disease. Int Urol Nephrol. 2014;46(8):1619-1625.
- Ganjali S, Gotto AM Jr, Ruscica M, et al. Monocyte-to-HDL-cholesterol ratio as a prognostic markerin cardiovascular diseases. J Cell Physiol. 2018;233(12):9237-9246.
- Enhos A, Cosansu K, Huyut MA, et al. Assessment of the relationship between monocyte to high-density lipoprotein ratio and myocardial bridge. Arq Bras Cardiol. 2019;112(1):12-17.
- Egeberg A, Gislason GH, Hansen PR. Risk of major adverse cardiovascular events and all-cause mortality in patients with hidradenitis suppurativa. JAMA Dermatol. 2016;152(4):429-434
- González-López MA, Hernández JL, Lacalle M, et al. Increased prevalence of subclinical atherosclerosis in patients with hidradenitis suppurativa (HS). J Am Acad Dermatol. 2016;75(2):329-335.
- Reddy S, Strunk A, Jemec GBE, Garg A. Incidence of myocardial infarction and cerebrovascular accident in patients with hidradenitis suppurativa. JAMA Dermatol. 2020;156(1):65-71.
- Turkmen D, Altunisik N, Sener S. Investigation of monocyte HDL ratio as an indicator of inflammation and complete blood count parameters in patients with acne vulgaris. Int J Clin Pract. 2020;74(12):e13639.
Evaluation of monocyte to high-density lipoprotein cholesterol ratio and other inflammatory markers in hidradenitis suppurativa: a case-control study
Abstract
Aims: Hidradenitis suppurativa (HS) is an inflammatory disease whose pathophysiology is not yet clearly known, but inflammatory parameters have been used for many years in the diagnosis and follow-up. The aim of this study is to evaluate NLR, PLR, MHR, and hemogram parameters in patients diagnosed with HS without comorbidities and compare them with healthy controls.
Methods: This study include 105 HS patients and 100 healthy volunteers. The medical records and laboratory findings of the participants were reviewed retrospectively. Patients and control group neutrophils, lymphocytes, monocytes, platelets, mean platelet volume (MPV), platelet distribution width (PDW), red cell distribution width coefficient of variation (RDW-CV), high-density lipoprotein cholesterol (HDL-C), C-reactive protein (CRP), Neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR), and MHR were compared.
Results: A total of 105 patients [43 (41%) women and 62 (59%) men] and one hundred healthy volunteers [52 (52%) women and 48 (48%) men] participated in the study. The mean of neutrophil count (patient group=5.84±2.27, control group=4.29±1.81, p=0.001), lymphocyte count (patient group=2.78±0.90, control group=2.31±0.63, p=0.001), monocyte count (patient group=0.74±0.39, control group=0.55±0.16, p=0.001), platelet count (patient group=295.63±65.84, control group=274.45±59.06, p=0.007), CRP (patient group=12.71±24.38, control group=2.61±2.21, p=0.039), and MHR (patient group=0.0203±0.0135, control group=0.0114±0.0056, p=0.001) were higher in the patient whereas the mean of HDL-C (patient group=39.02±11.06, control group=52.85±16.46, p=0.001) and PLR (patient group=118.82±60.82, control group=126.07±39.13, p=0.028) were significantly higher in control individuals. The adjusted effect of MHR, NLR, and PLR was re-examined to eliminate the effect that may arise from the difference in age between patients and controls. It was observed that when MHR increased by 0.01 unit, the risk of disease increased significantly by 4.07 times. When NLR increases by 1 unit, the disease increased. significantly by 1.37 times. Both adjusted and unadjusted effects of MHR were significant. When the sensitivity and specificity of MHR, and NLR in differentiating patients were examined, the sensitivity of MHR was found to be 67.4% and its specificity was 72.5% (p=0.001), while the sensitivity of NLR was found to be 61.5% and its specificity was 74.0% ( p=0.038).
Conclusions: Our study showed that MHR was more effective in distinguishing HS patients than other inflammatory markers. MHR can be used as a new marker to investigate the inflammatory effect of HS.
References
- Yaşar NF, Uylas MU, Baspinar M, et al. Evaluating the use of hematological parameters in staging hidradenitis suppurativa. Wounds. 2016;28(11):87-91.
- Ünal A. Evaluation of mean platelet volume and platelet count in patients with hidradenitis suppurativa. TURKDERM-Turk Arch Dermatol Venereol. 2021;55:189-192.
- Cartron A, Driscoll MS. Comorbities of hidradenitis suppurativa: A review of the literature. Int J Womens Dermatol. 2019;5(5):330-334
- Saunte DML, Jemec GBE. Hidradenitis suppurativa: advances in diagnosis and treatment. JAMA. 2017;318(20):2019-2032.
- Lapic I, Padoan A, Bozzato D, Plebani M. Erythrocyte sedimentation rate and C-reactive protein in acute inflammation. Am J Clin Pathol. 2020;153(1):14-29.
- Kutlu Ö. Effect of isotretinoin treatment on the inflammatory markers in patients with acne vulgaris: can monocyte/HDL be a new indicator for inflammatory activity of isotretinoin treatment? Cutan Ocul Toxicol. 2020;39(1):67-70.
- Gambichler T, Hessam S, Cramer P, Abu Rached N, Bechara FG. Complete blood collection-based systemic inflammation biomarkers for patients with hidradenitis suppurativa. J Eur Acad Dermatol Venereol. 2022;36(9):1593-1596.
- Demirbaş A, Elmas ÖF, Atasoy M, Türsen Ü, Lotti T. Can monocyte to HDL cholesterol ratio and monocyte to lymphocyte ratio be markers for inflammation and oxidative stress in patients with vitiligo? a preliminary study. Arch Dermatol Res. 2021;313(6):491-498.
- Metin N, Turan Ç. Increases in uric acid and monocyte-high-density lipoprotein ratio as possible atherosclerotic indicators in acne patients using isotretinoin. J Cosmet Dermatol. 2021;20(9):2945-2949.
- Çetinarslan T, Türel Ermertcan A, Özyurt B, Gündüz K. Evaluation of the laboratory parameters in hidradenitis suppurativa: can we use new inflammatory biomarkers? Dermatol Ther. 2021;34(2):e14835.
- Ekiz O, Balta I, Sen BB, et al. Mean platelet volume in recurrent aphthous stomatitis and Behçet disease. Angiology. 2014;65(2):161–165.
- Stefaniuk P, Szymczyk A, Podhorecka M. The Neutrophil to lymphocyte and lymphocyte to monocyte ratios as new prognostic factors in hematological malignancies - a narrative review. Cancer Manag Res. 2020;12:2961-2977.
- Öksüm Solak E, Baran Ketencioglu B, Cinar SL, Kartal D, Borlu M. The role of new inflammatory markers in determining disease activation and severity in patients with hidradenitis suppurativa. Int J Dermatol. 2023;62(8):1076-1081.
- Miller IM, Ring HC, Prens EP, et al. Leukocyte profile in peripheral blood and neutrophil-lymphocyte ratio in hidradenitis suppurativa: a comparative cross-sectional study of 462 cases. Dermatology. 2016;232(4):511-519.
- Kim DS, Lee J, Kim SH, Kim SM, Lee MG. Mean platelet volumeis elevated in patients with psoriasis vulgaris. Yonsei Med J. 2015;56(3):712-718.
- Kılıç S, Reşorlu H, Işik S, et al. Association between mean platelet volume and disease severity in patients with psoriasis and psoriatic arthritis. Postepy Dermatol Alergol. 2017;34(2):126-130.
- Sirin MC, Korkmaz S, Erturan I, et al. Evaluation of monocyte to HDL cholesterol ratio and other inflammatory markers in patients with psoriasis. An Bras Dermatol. 2020;95(5):575-582.
- Canpolat F, Akpınar H, Eskioglu F. Mean platelet volume in psoriasis and psoriatic arthritis. Clin Rheumatol. 2010;29(3):325–328.
- Ataş H, Canpolat F, Eskioglu F. Evaluation of mean platelet volume in patients with Behcet's disease as an indicator of vascular thrombosis. Arch Iran Med. 2018;21(6):234-239.
- Lippi G, Buonocore R, Cervellin G. The mean platelet volume is decreased in patients diagnosed with venous thromboembolism in the emergency department. Semin Thromb Hemost. 2016;42(6):632-635.
- Kanbay M, Solak Y, Unal HU, et al. Monocyte count/HDL cholesterol ratio and cardiovascular events in patients with chronic kidney disease. Int Urol Nephrol. 2014;46(8):1619-1625.
- Ganjali S, Gotto AM Jr, Ruscica M, et al. Monocyte-to-HDL-cholesterol ratio as a prognostic markerin cardiovascular diseases. J Cell Physiol. 2018;233(12):9237-9246.
- Enhos A, Cosansu K, Huyut MA, et al. Assessment of the relationship between monocyte to high-density lipoprotein ratio and myocardial bridge. Arq Bras Cardiol. 2019;112(1):12-17.
- Egeberg A, Gislason GH, Hansen PR. Risk of major adverse cardiovascular events and all-cause mortality in patients with hidradenitis suppurativa. JAMA Dermatol. 2016;152(4):429-434
- González-López MA, Hernández JL, Lacalle M, et al. Increased prevalence of subclinical atherosclerosis in patients with hidradenitis suppurativa (HS). J Am Acad Dermatol. 2016;75(2):329-335.
- Reddy S, Strunk A, Jemec GBE, Garg A. Incidence of myocardial infarction and cerebrovascular accident in patients with hidradenitis suppurativa. JAMA Dermatol. 2020;156(1):65-71.
- Turkmen D, Altunisik N, Sener S. Investigation of monocyte HDL ratio as an indicator of inflammation and complete blood count parameters in patients with acne vulgaris. Int J Clin Pract. 2020;74(12):e13639.
Details
| Primary Language | English |
|---|---|
| Subjects | Dermatology |
| Journal Section | Original Article |
| Authors | |
| Early Pub Date | October 28, 2023 |
| Publication Date | October 29, 2023 |
| Published in Issue | Year 2023 Volume: 6 Issue: 6 |
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