Evaluation of Antibiofilm and Antimicrobial Activities of N-heterocyclic Carbene Complexes

Uğur Tutar; Cem Çelik; Mehmet Ataş

doi:10.17776/csj.1390256

EN

Evaluation of Antibiofilm and Antimicrobial Activities of N-heterocyclic Carbene Complexes

Abstract

In recent years, resistance to antimicrobials has become a global problem. Despite the need for new antibiotics with the increase of resistant bacteria, developing new antimicrobials is problematic. Biofilms formed by microorganisms play an essential role in the development of resistance. We aimed to investigate the antimicrobial and antibiofilm activities of N-heterocyclic carbene (NHC) complexes. In this study, previously synthesized and characterized NHC complexes on standard bacterial and fungal strains were investigated. The minimal inhibition concentration (MIC) test was used to determine the antimicrobial activities of the compounds, and the biofilm inhibition concentration test was used to determine the anti-biofilm activities. Compounds 2b and 2c showed potent antimicrobial activity on microorganisms between <=1.9 and 7.8µg/mL. Antimicrobial activity in salts of compounds (1a-1c) was weaker than silver compounds (2a-2c). The antibiofilm activity was between 27 and 79%, especially in silver-bound compounds (2a-2c). Benzimidazole derivative NHC compounds that we evaluated in our study were found to have significant antimicrobial and antibiofilm effects on pathogenic microorganisms. These compounds, which we assessed in our study, may be antimicrobial drug candidates that can be used in different areas. It will be essential to conduct further in vitro and in vivo studies on this subject.

Keywords

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Çalışmada kullanılan bileşiklerin temini konusunda destek veren Doç Dr Neslihan Şahine teşekkür ederiz

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Details

Primary Language

English

Subjects

Pharmacology and Pharmaceutical Sciences (Other)

Journal Section

Research Article

Authors

Uğur Tutar ^*
0000-0002-8058-0994
Türkiye

Cem Çelik
0000-0002-7141-5874
Türkiye

Mehmet Ataş
0000-0002-9425-0080
Türkiye

Publication Date

March 28, 2024

Submission Date

November 13, 2023

Acceptance Date

March 12, 2024

Published in Issue

Year 1970 Volume: 45 Number: 1

DOI

https://doi.org/10.17776/csj.1390256

IZ

https://izlik.org/JA46ZM32YW

Cite

RIS / Bibtex

APA

Tutar, U., Çelik, C., & Ataş, M. (2024). Evaluation of Antibiofilm and Antimicrobial Activities of N-heterocyclic Carbene Complexes. Cumhuriyet Science Journal, 45(1), 29-34. https://doi.org/10.17776/csj.1390256

Cited By

Multifunctional benzimidazolium derivatives as anticancer, antibacterial, and acetylcholinesterase inhibitors: In vitro and molecular docking studies

Archives of Biochemistry and Biophysics

https://doi.org/10.1016/j.abb.2025.110630

Öz

Evaluation of Antibiofilm and Antimicrobial Activities of N-heterocyclic Carbene Complexes

Abstract

Keywords

Thanks

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

Multifunctional benzimidazolium derivatives as anticancer, antibacterial, and acetylcholinesterase inhibitors: In vitro and molecular docking studies