Chemometric Determination of Parkinson's Drugs Containing Multiple Active Substances

Ayşe Merve Arslan; Güzide Pekcan

doi:10.17776/csj.1351879

EN

Chemometric Determination of Parkinson's Drugs Containing Multiple Active Substances

Abstract

In this work, the active ingredients of Entacapone, Levodopa and Carbidopa in drug samples used in the treatment of Parkinson's disease were quantitatively determined by Ultraviolet Visible (UV-VIS) Spectroscopy and chemometrics. Firstly, the spectra of each drug active ingredient were taken individually and then synthetic mixtures identical to the drug sample were analyzed. In our method, validation parameters were calculated for each method. Percent (%) recoveries were found on average for both the synthetic mixture and the commercial sample. The recoveries were quantitative for each method. The accuracy of the methods was tested by applying ANOVA test to the results obtained from the PLS and PCR calibration methods. The developed methods are reproducible, sensitive, and accurate, and can be recommended for the analysis of drug samples containing Entacapone, Levodopa, and Carbidopa

Keywords

References

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Details

Primary Language

English

Subjects

Analytical Chemistry (Other)

Journal Section

Research Article

Authors

Ayşe Merve Arslan
0000-0001-6044-8403
Türkiye

Güzide Pekcan ^*
0000-0001-9230-5634
Türkiye

Publication Date

March 28, 2024

Submission Date

August 29, 2023

Acceptance Date

January 2, 2024

Published in Issue

Year 2024 Volume: 45 Number: 1

DOI

https://doi.org/10.17776/csj.1351879

IZ

https://izlik.org/JA64US22LT

Cite

RIS / Bibtex

APA

Arslan, A. M., & Pekcan, G. (2024). Chemometric Determination of Parkinson’s Drugs Containing Multiple Active Substances. Cumhuriyet Science Journal, 45(1), 47-53. https://doi.org/10.17776/csj.1351879

Chemometric Determination of Parkinson's Drugs Containing Multiple Active Substances

Abstract

Keywords

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References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite