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Chemometric Determination of Parkinson's Drugs Containing Multiple Active Substances

Year 2024, Volume: 45 Issue: 1, 47 - 53, 28.03.2024

Ayşe Merve Arslan , Güzide Pekcan

https://doi.org/10.17776/csj.1351879

Abstract

In this work, the active ingredients of Entacapone, Levodopa and Carbidopa in drug samples used in the treatment of Parkinson's disease were quantitatively determined by Ultraviolet Visible (UV-VIS) Spectroscopy and chemometrics. Firstly, the spectra of each drug active ingredient were taken individually and then synthetic mixtures identical to the drug sample were analyzed. In our method, validation parameters were calculated for each method. Percent (%) recoveries were found on average for both the synthetic mixture and the commercial sample. The recoveries were quantitative for each method. The accuracy of the methods was tested by applying ANOVA test to the results obtained from the PLS and PCR calibration methods. The developed methods are reproducible, sensitive, and accurate, and can be recommended for the analysis of drug samples containing Entacapone, Levodopa, and Carbidopa

Keywords

Entacapone Levodopa Carbidopa Chemometry

References

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  • [2] Şahin A.R., Arık A.C., Depresyon ve Parkinson hastalığı, O.M.Ü. Tıp Dergisi, 11(3) (1994) 239-246.
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  • [7] Bugamelli F., Marcheselli C., Barba E., Raggi M.A., Determination of L-dopa, carbidopa, 3-O-methyldopa and entacapone in human plasma by HPLC–ED, Journal of Pharmaceutical and Biomedical Analysis, 54 (2011) 562-567.
  • [8] Dinç E., Kemometri Çok Değişkenli Kalibrasyon Yöntemleri, Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi, 27(1) (2007) 61-92.
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  • [11] Benvidi A., Dehghani-Firouzabadi A., Mazloum-Ardakani M., Mirjalili B.F., Zare R., Electrochemical deposition of gold nanoparticles on reduced graphene oxide modified glassy carbon electrode for simultaneous determination of levodopa, uric acid and folic acid: Application of silver nanoparticles and principal component-artificial neural network models for simultaneous determination of levodopa and benserazide hydrochloride by a kinetic spectrophotometric. Journal of Electroanalytical Chemistry, 736 (2015) 22-29.
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  • [13] Tajika, S., Taher, M.A., Beitollahi, H., 2013, Simultaneous determination of droxidopa and carbidopa using a carbon nanotubes paste electrode, Sensors and Actuators B: Chemical, 188 (2013) 923-930.
  • [14] Abdel-Ghany, M.F., Hussein, L.A., Ayad, M.F., Youssef, M.M., Investigation of different spectrophotometric and chemometric methods for determination of entacapone, levodopa and carbidopa in ternary mixture, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 171 (2017) 236-245.
  • [15] Mantena, B.P.V., Rao, S.V., Rao, K.M.C.A., Ramakrishna, K., Reddy, R.S., Rapid Separation Technique for the Determination of Potential Impurities Present in Levodopa, Carbidopa, and Entacapone in Fixed Dose Combination Drug Product Using Trifunctionally Bonded Phase Ethylene Bridged Sorbent Column with Smaller Ion-Pair Reagent, Journal of Liquid Chromatography & Related Technologies, 38 (2015) 1073–1087.
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  • [18] Saganowska P., Wesolowski M., Principal Component and Cluster Analyses as Supporting Tools for Co‐CrystalsDetection, J.Therm.Anal.Calorim., (2017) 45‐55.
  • [19] Bajpai V., Kumar S., Singh A., Singh J., Negi M.P.S., Bag S.K., Kumar N., Konwar R., Kumar B., Chemometric based identification and validation of specific chemical markers for goegraphical, seasonal and gender variations in tinospora cordifolia stem using HPLC-ESI-QTOF-MS Analysis, Photochemical Analysis, 28(4), (2017) 277-288.
  • [20] Uyanık A., Analitik Kimyacılar İçin İstatistik ve Kemometri”, Pegem Akademi Yayıncılık, 6. Baskı (2012) 254-259.
  • [21] Bilgili A.V., Çullu M.A, Aydemir S., 2014, Tuzdan etkilenmiş toprakların yakın kızılötesi yansıma spektroradyometre ve elektromanyetik indüksiyon tekniği yardımıyla karakterize edilebilme potansiyelinin araştırılması , Harran Tarım ve Gıda Bilimleri Dergisi, 18(1) (2014) 32-45.
  • [22] A. Shrivastava, V.B. Gupta, Methods for the determination of limit of detection and limit of quantitation of tha analytical methods, Chronicles of Young Scientist, 2 (1), (2011) 21-25.
  • [23] Armbruster D.A., Pty T., Limit of blank, limit of detection and limit of quantitation, Clin Biochem Rev, 29 (2008) 49-52.
  • [24] Dinç E., Baleanu D., Spectrophotometric quantitative determination of cilazapril and hydrochlorothiazide in tablets by chemometric methods, Journal of Pharmaceutical and Biomedical Analysis, 30 (2002) 715-723.
  • [25] Dinç E., Özdemir A., Baleanu D., Comparative study of the continuous wavelent transform, derivative and partial least squares methods applied to the overlapping spectra for the simultaneous quantitative resolution of ascorbic acid and asetilsalicylic acid in effervescent tablets, , Journal of Pharmaceutical and Biomedical Analysis, 37 (2005) 715-723.
  • [26] Aktaş A.H., Sarıdağ A.M., Liquid chromatografic-chemometric tecnhniques for the simultaneous HPLC determination of lansoprazole, amoksisilin and clarithromisin in commercial preparation, Journal of Chromatografic Science, (2017) 1-7.
  • [27] Porfire A., Muntean D., Achim M., Vlase L., Tomuta I., Simultaneous Quantification of Simvastatin and Excipients in Liposomes Using Near Spectroscopy and Chemometry, Journal of Pharmaceutical and Biomedical Analysis, 107 (2015) 40-49.
  • [28] Tarhan I., Kara A.A.I.H, Quantitative Determination of Free Fatty Acids in Extra Virgin Olive Oils by Multivariate Methods and Fourier Transform Infrared Spectroscopy Considering Different Absorption Modes, International Journal of Food Properties, (2017) 1-8.

Year 2024, Volume: 45 Issue: 1, 47 - 53, 28.03.2024

Ayşe Merve Arslan , Güzide Pekcan

https://doi.org/10.17776/csj.1351879

Abstract

References

  • [1] Yalıman A., Şen E.İ., Parkinson Hastalığı ve Rehabilitasyonu, Türk Fiz Tıp Rehab. Derg., 57 (2011) 38-44.
  • [2] Şahin A.R., Arık A.C., Depresyon ve Parkinson hastalığı, O.M.Ü. Tıp Dergisi, 11(3) (1994) 239-246.
  • [3] Yiğit G., Arıcıoğlu F., Günümüz ve Gelecekte Parkinson Hastalığı için Farmakolojik Tedavi Yaklaşımları, MÜSBED, 5(4) (2015) 265-273.
  • [4] Pekcan Ertokuş G., Özer T., Parkinson Hastalığının Tedavisinde Kullanılan Levodopa ve Benserazid Etken Maddelerinin Kemometrik Tayini, Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 13(2), (2020) 669-676.
  • [5] Tashkhourian J., Hormozi-Nezhad M.R., Khodaveisi J., Application of silver nanoparticles and principal component-artificial neural network models for simultaneous determination of levodopa and benserazide hydrochloride by a kinetic spectrophotometric method, Spectrochimica acta. Part A, Molecular and Biomolecular Spectroscopy, 82(1) (2011) 25-30.
  • [6] Damiani P.C., Moschetti A.C., Rovetto A.J., Benavente F., Olivieri A.C., Design and optimization of a chemometrics-assisted spectrophotometric method for the simultaneous determination of levodopa and carbidopa in pharmaceutical products, Analytica Chimica Acta, 543 (2005) 192–198.
  • [7] Bugamelli F., Marcheselli C., Barba E., Raggi M.A., Determination of L-dopa, carbidopa, 3-O-methyldopa and entacapone in human plasma by HPLC–ED, Journal of Pharmaceutical and Biomedical Analysis, 54 (2011) 562-567.
  • [8] Dinç E., Kemometri Çok Değişkenli Kalibrasyon Yöntemleri, Hacettepe Üniversitesi Eczacılık Fakültesi Dergisi, 27(1) (2007) 61-92.
  • [9] Arslan A.M., Çoklu Etken Madde İçeren Parkinson İlaçlarının Kemometrik Tayini, Süleyman Demirel Üniversitesi, Fen Bilimleri Enstitüsü, 2023.
  • [10] Hosseini M.G., Faraji M.,Momeni M.M., Ershad S., An innovative electrochemical approach for voltammetric determination of levodopa using gold nanoparticles doped on titanium dioxide nanotubes. Microchim Acta, 172 (2011) 103-108.
  • [11] Benvidi A., Dehghani-Firouzabadi A., Mazloum-Ardakani M., Mirjalili B.F., Zare R., Electrochemical deposition of gold nanoparticles on reduced graphene oxide modified glassy carbon electrode for simultaneous determination of levodopa, uric acid and folic acid: Application of silver nanoparticles and principal component-artificial neural network models for simultaneous determination of levodopa and benserazide hydrochloride by a kinetic spectrophotometric. Journal of Electroanalytical Chemistry, 736 (2015) 22-29.
  • [12] Gholivanda M.B., Jalalvanda A.R., Goicoechea H.C., Multivariate analysis for resolving interactions of carbidopa withdsDNA at a fullerene-C60, International Journal of Biological Macromolecules, 69 (2014) 369-381.
  • [13] Tajika, S., Taher, M.A., Beitollahi, H., 2013, Simultaneous determination of droxidopa and carbidopa using a carbon nanotubes paste electrode, Sensors and Actuators B: Chemical, 188 (2013) 923-930.
  • [14] Abdel-Ghany, M.F., Hussein, L.A., Ayad, M.F., Youssef, M.M., Investigation of different spectrophotometric and chemometric methods for determination of entacapone, levodopa and carbidopa in ternary mixture, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 171 (2017) 236-245.
  • [15] Mantena, B.P.V., Rao, S.V., Rao, K.M.C.A., Ramakrishna, K., Reddy, R.S., Rapid Separation Technique for the Determination of Potential Impurities Present in Levodopa, Carbidopa, and Entacapone in Fixed Dose Combination Drug Product Using Trifunctionally Bonded Phase Ethylene Bridged Sorbent Column with Smaller Ion-Pair Reagent, Journal of Liquid Chromatography & Related Technologies, 38 (2015) 1073–1087.
  • [16] Minitab, Available at: https://www.inovadanismanlik.com.tr/ , Retrieved: 21.08.2023.
  • [17] Dinç E., Kemometrik İşlem ve Yöntemlerin Analitik Kimyadaki Tipik Uygulamaları, Uygulamalı Kemometri Yaz Okulu Notları. (2009) 13‐17.
  • [18] Saganowska P., Wesolowski M., Principal Component and Cluster Analyses as Supporting Tools for Co‐CrystalsDetection, J.Therm.Anal.Calorim., (2017) 45‐55.
  • [19] Bajpai V., Kumar S., Singh A., Singh J., Negi M.P.S., Bag S.K., Kumar N., Konwar R., Kumar B., Chemometric based identification and validation of specific chemical markers for goegraphical, seasonal and gender variations in tinospora cordifolia stem using HPLC-ESI-QTOF-MS Analysis, Photochemical Analysis, 28(4), (2017) 277-288.
  • [20] Uyanık A., Analitik Kimyacılar İçin İstatistik ve Kemometri”, Pegem Akademi Yayıncılık, 6. Baskı (2012) 254-259.
  • [21] Bilgili A.V., Çullu M.A, Aydemir S., 2014, Tuzdan etkilenmiş toprakların yakın kızılötesi yansıma spektroradyometre ve elektromanyetik indüksiyon tekniği yardımıyla karakterize edilebilme potansiyelinin araştırılması , Harran Tarım ve Gıda Bilimleri Dergisi, 18(1) (2014) 32-45.
  • [22] A. Shrivastava, V.B. Gupta, Methods for the determination of limit of detection and limit of quantitation of tha analytical methods, Chronicles of Young Scientist, 2 (1), (2011) 21-25.
  • [23] Armbruster D.A., Pty T., Limit of blank, limit of detection and limit of quantitation, Clin Biochem Rev, 29 (2008) 49-52.
  • [24] Dinç E., Baleanu D., Spectrophotometric quantitative determination of cilazapril and hydrochlorothiazide in tablets by chemometric methods, Journal of Pharmaceutical and Biomedical Analysis, 30 (2002) 715-723.
  • [25] Dinç E., Özdemir A., Baleanu D., Comparative study of the continuous wavelent transform, derivative and partial least squares methods applied to the overlapping spectra for the simultaneous quantitative resolution of ascorbic acid and asetilsalicylic acid in effervescent tablets, , Journal of Pharmaceutical and Biomedical Analysis, 37 (2005) 715-723.
  • [26] Aktaş A.H., Sarıdağ A.M., Liquid chromatografic-chemometric tecnhniques for the simultaneous HPLC determination of lansoprazole, amoksisilin and clarithromisin in commercial preparation, Journal of Chromatografic Science, (2017) 1-7.
  • [27] Porfire A., Muntean D., Achim M., Vlase L., Tomuta I., Simultaneous Quantification of Simvastatin and Excipients in Liposomes Using Near Spectroscopy and Chemometry, Journal of Pharmaceutical and Biomedical Analysis, 107 (2015) 40-49.
  • [28] Tarhan I., Kara A.A.I.H, Quantitative Determination of Free Fatty Acids in Extra Virgin Olive Oils by Multivariate Methods and Fourier Transform Infrared Spectroscopy Considering Different Absorption Modes, International Journal of Food Properties, (2017) 1-8.
There are 28 citations in total.

Details

Primary Language English
Subjects Analytical Chemistry (Other)
Journal Section Natural Sciences
Authors

Ayşe Merve Arslan 0000-0001-6044-8403

Güzide Pekcan 0000-0001-9230-5634

Publication Date March 28, 2024
Submission Date August 29, 2023
Acceptance Date January 2, 2024
Published in Issue Year 2024Volume: 45 Issue: 1

Cite

APA Arslan, A. M., & Pekcan, G. (2024). Chemometric Determination of Parkinson’s Drugs Containing Multiple Active Substances. Cumhuriyet Science Journal, 45(1), 47-53. https://doi.org/10.17776/csj.1351879
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