Research Article
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Year 2022, Volume: 3 Issue: 2, 64 - 70, 05.08.2022
https://doi.org/10.53811/ijtcmr.1040648

Abstract

References

  • Hackett GS, Hemwall GA MG. Ligaments and Tendon Relaxation Treated by Prolotherapy. 5th ed. Hackett Hemwall Foundation; 2008.
  • Carayannopoulos A, Borg-Stein J, Sokolof J, Meleger A, Rosenberg D. Prolotherapy Versus Corticosteroid Injections for the Treatment of Lateral Epicondylosis: A Randomized Controlled Trial. PM R 2011;3(8):706-715.
  • Rabago D, Lee KS, Ryan M, Chourasia AO, Sesto ME, Zgierska A, Kijowski R, Grettie J, Wilson J, Miller D. Hypertonic dextrose and morrhuate sodium injections (prolotherapy) for lateral epicondylosis (tennis elbow): Results of a single-blind, pilot-level, randomized controlled trial. Am J Phys Med Rehabil 2013;92(7):587-596.
  • Solmaz I, Orscelik A. Features and Clinical Effectiveness of the Regenerative Injection Treatments: Prolotherapy and Platelet-Rich Plasma for Musculoskeletal Pain Management. In: Cascella M, ed. From Conventional to Innovative Approaches for Pain Treatment. 1st ed. IntechOpen; 2019:73-86.
  • Ersen O, Koca K, Akpancar S, Seven MM, Akyıldız F, Yıldız Y, Ozkan H. A randomized-controlled trial of prolotherapy injections in the treatment of plantar fasciitis. Turkish J Phys Med Rehabil 2018;64(1):59-65.
  • Yıldız Y, Apaydın AH, Seven MM, Orscelik A. The Effects of Prolotherapy (Hypertonic Dextrose) in Recreational Athletes with Patellofemoral Pain Syndrome. J Exp Integr Med 2016;6(2):53.
  • Orscelik A, Akpancar S, Seven MM, Erdem Y, Koca K. The Efficacy of Platelet Rich Plasma and Prolotherapy in Chondromalacia Patella Treatment. Turkish J Sport Med 2020;55(1):28-37.
  • Solmaz I, Akpancar S, Orscelik A, Yener-Karasimav O, Gül D. Dextrose injections for failed back surgery syndrome: a consecutive case series. Eur Spine J 2019;28(7):1610-1617.
  • Akpancar S, Orscelik A, Murat SM, Kenan K. The effectiveness of prolotherapy on failed rotator cuff repair surgery. Turkish J Phys Med Rehabil 2019;65(4):394-401.
  • Güran Ş, Dilşad çoban Z, Karasimav Ö, Demirhan S, Karaağaç N, Örsçelik A, Altayli E, Yildiz Y. Dextrose solution used for prolotherapy decreases cell viability and increases gene expressions of angiogenic and apopitotic factors. Gulhane Med J 2018;60(2):42-46.
  • Rabago D, Reeves KD, Doherty MP, Fleck M. Prolotherapy for Musculoskeletal Pain and Disability in Low- and Middle-Income Countries. Phys Med Rehabil Clin N Am 2019;30(4):775-786.
  • Solmaz I, Orscelik A, Karasimav Ö, Akpancar S. Is prolotherapy effective in the treatment of avascular necrosis of the femoral head? Altern Ther Health Med 2019;25(5):54-56.
  • Erdem Y, Gul D, Akpancar S. Comparison of Intraarticular Injections of Hyaluronic Acid versus Dextrose Applied with Periarticular Prolotherapy in the Treatment of Recreational Athletes with Knee Osteoarthritis. Turkish J Sport Med 2020;55(1):6-13.
  • Apaydin AH, Orscelik A, Yildiz Y. The Effects of Prolotherapy in Recreational Athletes with Plantar Fasciitis. Turkish J Sport Med 2018;53(1):37-46.
  • Köroğlu O, Orscelik A, Karasimav Ö, Demir Y, Solmaz I. Is 5% dextrose prolotherapy effective for radicular low back pain? Gulhane Med J 2019;61(3):123.
  • Gül D, Orscelik A, Akpancar S. Treatment of Osteoarthritis Secondary to Developmental Dysplasia of the Hip with Prolotherapy Injection versus a Supervised Progressive Exercise Control. Med Sci Monit 2020;26:e919166-1–e919166-8.
  • Fleming S, Rabago DP, Mundt MP, Fleming MF. CAM therapies among primary care patients using opioid therapy for chronic pain. BMC Complement Altern Med 2007;7(1):15.
  • Dagenais S, Jaime C, Scott H. A systematic review of low back pain cost of illness studies in the United States and internationally. Spine J 2008;8(1):8-20.
  • Dagenais S, Yelland MJ, Del Mar C, Schoene ML. Prolotherapy injections for chronic low-back pain. Cochrane Database Syst Rev 2007;18(2).
  • Yelland MJ, Glasziou PP, Bogduk N, Schluter PJ, McKernon M. Prolotherapy Injections, Saline Injections, and Exercises for Chronic Low-Back Pain: A Randomized Trial. Spine (Phila Pa 1976) 2004;29(1):9-16.
  • Kim WM, Lee HG, Won Jeong C, Kim CM, Yoon MH. A Randomized Controlled Trial of Intra-Articular Prolotherapy Versus Steroid Injection for Sacroiliac Joint Pain. J Altern Complement Med 2010;16(12):1285-1290.
  • Dechow E, Davies RK, Carr AJ, Thompson PW. A randomized, double-blind, placebo-controlled trial of sclerosing injections in patients with chronic low back pain. Rheumatology 1999;38(12):1255-1259.
  • Solmaz İ, Orscelik A, Köroğlu Ö. Modified Prolotherapy by 5% Dextrose. Two Years Experıences Of A Traditional and Complementary Medicine Practıce Center. J Back Musculoskelet Rehabil. 2022;35(4):763-770.
  • Dagenais S, Haldeman S, Wooley JR. Intraligamentous injection of sclerosing solutions (prolotherapy) for spinal pain: a critical review of the literature. Spine J 2005;5(3):310-328.
  • Reeves KD, Klein RG DW. Prolotherapy injections, saline injections, and exercises for chronic low-back pain: a randomized study. Spine (Phila Pa 1976) 2004;29:1839-1840.
  • Miller, Matthew R, Matthews, Robert S RKD. Treatment of painful advanced internal lumbar disc derangement with intradiscal injection of hypertonic dextrose. Pain Physician, 2006;9(2):115-121.

Approximately Three Years of Prolotherapy Experience of a Traditional and Complementary Medicine Center: An Epidemiologic Study

Year 2022, Volume: 3 Issue: 2, 64 - 70, 05.08.2022
https://doi.org/10.53811/ijtcmr.1040648

Abstract

Objective: Prolotherapy is a regenerative injection-based treatment which is increasingly using in musculoskeletal disorders. There are studies about the usage of prolotherapy in diseases but there is not an epidemiological study in the literature. The aim of this study is to resolve the lack of epidemiological studies about prolotherapy.
Materials-Methods: Ten-thousand-three-hundred-nineteen patients who were applied to our outpatient clinic between January 1, 2017 and 2021 were included in the study.
Results: The number of patients’ injured area was 10319 with the mean age of 54.2±13.8. 2886 male (28.0%) and 7433 females (72.0%) were evaluated, and 844 of these patients (8.2%) did not receive the treatment. The reasons for admission / treatment of the patients were 35.3% (3647) low back and hip pain, 33.9% (3503) osteoarthritis of the knee, 13.3% (1369) neck pain. The number of sessions was 3.90±2.0 for completed treatments. Treatment results of the patients showed a significant difference according to gender (p<0.001). There was a statistically significant difference between the mean number of sessions according to the gender of the patients (p<0.001). There was a significant relationship between the age of the patients and the treatment results according to the results of the one-way analysis of variance (Anova) (p<0.001). There is a significant difference between the mean of sessions according to the diagnosis distribution of patients (p<0.001).
Conclusions: Better results can be obtained with the right patient selection and informing the patient correctly. Epidemiological studies are of great importance to learn these.

References

  • Hackett GS, Hemwall GA MG. Ligaments and Tendon Relaxation Treated by Prolotherapy. 5th ed. Hackett Hemwall Foundation; 2008.
  • Carayannopoulos A, Borg-Stein J, Sokolof J, Meleger A, Rosenberg D. Prolotherapy Versus Corticosteroid Injections for the Treatment of Lateral Epicondylosis: A Randomized Controlled Trial. PM R 2011;3(8):706-715.
  • Rabago D, Lee KS, Ryan M, Chourasia AO, Sesto ME, Zgierska A, Kijowski R, Grettie J, Wilson J, Miller D. Hypertonic dextrose and morrhuate sodium injections (prolotherapy) for lateral epicondylosis (tennis elbow): Results of a single-blind, pilot-level, randomized controlled trial. Am J Phys Med Rehabil 2013;92(7):587-596.
  • Solmaz I, Orscelik A. Features and Clinical Effectiveness of the Regenerative Injection Treatments: Prolotherapy and Platelet-Rich Plasma for Musculoskeletal Pain Management. In: Cascella M, ed. From Conventional to Innovative Approaches for Pain Treatment. 1st ed. IntechOpen; 2019:73-86.
  • Ersen O, Koca K, Akpancar S, Seven MM, Akyıldız F, Yıldız Y, Ozkan H. A randomized-controlled trial of prolotherapy injections in the treatment of plantar fasciitis. Turkish J Phys Med Rehabil 2018;64(1):59-65.
  • Yıldız Y, Apaydın AH, Seven MM, Orscelik A. The Effects of Prolotherapy (Hypertonic Dextrose) in Recreational Athletes with Patellofemoral Pain Syndrome. J Exp Integr Med 2016;6(2):53.
  • Orscelik A, Akpancar S, Seven MM, Erdem Y, Koca K. The Efficacy of Platelet Rich Plasma and Prolotherapy in Chondromalacia Patella Treatment. Turkish J Sport Med 2020;55(1):28-37.
  • Solmaz I, Akpancar S, Orscelik A, Yener-Karasimav O, Gül D. Dextrose injections for failed back surgery syndrome: a consecutive case series. Eur Spine J 2019;28(7):1610-1617.
  • Akpancar S, Orscelik A, Murat SM, Kenan K. The effectiveness of prolotherapy on failed rotator cuff repair surgery. Turkish J Phys Med Rehabil 2019;65(4):394-401.
  • Güran Ş, Dilşad çoban Z, Karasimav Ö, Demirhan S, Karaağaç N, Örsçelik A, Altayli E, Yildiz Y. Dextrose solution used for prolotherapy decreases cell viability and increases gene expressions of angiogenic and apopitotic factors. Gulhane Med J 2018;60(2):42-46.
  • Rabago D, Reeves KD, Doherty MP, Fleck M. Prolotherapy for Musculoskeletal Pain and Disability in Low- and Middle-Income Countries. Phys Med Rehabil Clin N Am 2019;30(4):775-786.
  • Solmaz I, Orscelik A, Karasimav Ö, Akpancar S. Is prolotherapy effective in the treatment of avascular necrosis of the femoral head? Altern Ther Health Med 2019;25(5):54-56.
  • Erdem Y, Gul D, Akpancar S. Comparison of Intraarticular Injections of Hyaluronic Acid versus Dextrose Applied with Periarticular Prolotherapy in the Treatment of Recreational Athletes with Knee Osteoarthritis. Turkish J Sport Med 2020;55(1):6-13.
  • Apaydin AH, Orscelik A, Yildiz Y. The Effects of Prolotherapy in Recreational Athletes with Plantar Fasciitis. Turkish J Sport Med 2018;53(1):37-46.
  • Köroğlu O, Orscelik A, Karasimav Ö, Demir Y, Solmaz I. Is 5% dextrose prolotherapy effective for radicular low back pain? Gulhane Med J 2019;61(3):123.
  • Gül D, Orscelik A, Akpancar S. Treatment of Osteoarthritis Secondary to Developmental Dysplasia of the Hip with Prolotherapy Injection versus a Supervised Progressive Exercise Control. Med Sci Monit 2020;26:e919166-1–e919166-8.
  • Fleming S, Rabago DP, Mundt MP, Fleming MF. CAM therapies among primary care patients using opioid therapy for chronic pain. BMC Complement Altern Med 2007;7(1):15.
  • Dagenais S, Jaime C, Scott H. A systematic review of low back pain cost of illness studies in the United States and internationally. Spine J 2008;8(1):8-20.
  • Dagenais S, Yelland MJ, Del Mar C, Schoene ML. Prolotherapy injections for chronic low-back pain. Cochrane Database Syst Rev 2007;18(2).
  • Yelland MJ, Glasziou PP, Bogduk N, Schluter PJ, McKernon M. Prolotherapy Injections, Saline Injections, and Exercises for Chronic Low-Back Pain: A Randomized Trial. Spine (Phila Pa 1976) 2004;29(1):9-16.
  • Kim WM, Lee HG, Won Jeong C, Kim CM, Yoon MH. A Randomized Controlled Trial of Intra-Articular Prolotherapy Versus Steroid Injection for Sacroiliac Joint Pain. J Altern Complement Med 2010;16(12):1285-1290.
  • Dechow E, Davies RK, Carr AJ, Thompson PW. A randomized, double-blind, placebo-controlled trial of sclerosing injections in patients with chronic low back pain. Rheumatology 1999;38(12):1255-1259.
  • Solmaz İ, Orscelik A, Köroğlu Ö. Modified Prolotherapy by 5% Dextrose. Two Years Experıences Of A Traditional and Complementary Medicine Practıce Center. J Back Musculoskelet Rehabil. 2022;35(4):763-770.
  • Dagenais S, Haldeman S, Wooley JR. Intraligamentous injection of sclerosing solutions (prolotherapy) for spinal pain: a critical review of the literature. Spine J 2005;5(3):310-328.
  • Reeves KD, Klein RG DW. Prolotherapy injections, saline injections, and exercises for chronic low-back pain: a randomized study. Spine (Phila Pa 1976) 2004;29:1839-1840.
  • Miller, Matthew R, Matthews, Robert S RKD. Treatment of painful advanced internal lumbar disc derangement with intradiscal injection of hypertonic dextrose. Pain Physician, 2006;9(2):115-121.
There are 26 citations in total.

Details

Primary Language English
Subjects Traditional, Complementary and Integrative Medicine
Journal Section Research Articles
Authors

İlker Solmaz 0000-0002-1959-8159

Aydan Örsçelik 0000-0002-8610-8869

Early Pub Date August 5, 2022
Publication Date August 5, 2022
Submission Date December 23, 2021
Published in Issue Year 2022 Volume: 3 Issue: 2

Cite

APA Solmaz, İ., & Örsçelik, A. (2022). Approximately Three Years of Prolotherapy Experience of a Traditional and Complementary Medicine Center: An Epidemiologic Study. International Journal of Traditional and Complementary Medicine Research, 3(2), 64-70. https://doi.org/10.53811/ijtcmr.1040648

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