In this study, chlorpyrifos, catechin, quercetin and catechin- or quercetin+chlorpyrifos were given to Wistar rats for 4 weeks. Chlorpyrifos increased the levels of malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT); decreased glutathione peroxidase (GPx) and glutathione–S-transferase (GST) activities in heart compared to the control. In catechin- and quercetin+chlorpyrifos groups, we observed the protective effects of flavonoids on examining parameters. Light microscopic investigations revealed that chlorpyrifos induced histopathological alterations in heart. Milder histopathological changes were observed co-treated with catechin- or quercetin+chlorpyrifos. As a result, catechin and quercetin significantly reduce chlorpyrifos induced cardiotoxicity in rats, but they aren’t protect completely.
Primary Language | English |
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Subjects | Engineering |
Journal Section | Biology |
Authors | |
Publication Date | November 25, 2011 |
Published in Issue | Year 2011 Volume: 24 Issue: 3 |