Research Article
SİKLOBÜTAN HALKALI TİYOSEMİKARBAZON TÜREVLİ SCHIFF BAZLARININ TAVŞAN KARACİĞERİNDEKİ YAĞ ASİTLERİNE ETKİSİNİN İNCELENMESİ
Abstract
Tiyosemikarbazonlu schiff
bazlarının türevleri ile metal komplekslerinin antitümör, antifungal ve
antibakteri-yel aktivitesi, olduğu bilinmektedir. Bu
çalışmada tiyosemikarbazon türevli l-(l-mesitil-l-metilsiklobütan-3-il)
- 2-suksinimido etanon tiyosemikarbazon (MSTSC) ve
l-(l-fenil-l-metilsiklobutan-3-il)-2-suksinimido etanon tiyosemikarbazon
(FSTSC) maddelerinin tavşan karaciğerlerindeki yağ asitleri üzerine etkileri araştırıldı.
Bu amaçla kontrol ve uygulama grupları oluşturuldu. Uygulama grubu olarak deri
altına, l-(l-mesitil-l-metilsiklo-bütan-3-il)-2-suksinimido etanon
tiyosemikarbazon (MSTSC) ve l-(l-fenil-l-metilsiklobutan-3-il)-2-suksini-mido
etanon tiyosemikarbazon (FSTSC) enjekte edilen tavşanlar kullanıldı. Tavşanların
karaciğer dokusun-daki yağ asitleri, gaz kromatoğrafisi ile tayin edildi.
Kontrol grubu ile deney grupları istatistiksel olarak karşılaştırıldığında; MSTSC
ve FSTSC grupları palmitik asit (C16:0), stearik asit (C18:0) miktarı azalırken
(p<0,01), ), oleik (C18:1) ve linoleik asidin (C18:2) miktarı artmıştır (p<0,001).
Sonuç
olarak uygulanan maddeler metabolizmada doymuş yağ asitleri düzeylerini
azaltarak, doymamış yağ asitleri düzeylerini artırabileceğini düşünülmektedir. TSC
türevlerinin araştırılan birçok farmakolojik özellik-lerine ilave olarak
araştırdığımız bu parametrelerin de literatür bilgisine katkıda bulunabileceği
söylenebilir.
Keywords
References
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- 15. Jain, S.K. and Palmer, M., 1997, The Effect of Oxygen Radicals Metabolites and Vitamin E on Glycosylation of Proteins, Free Radical Biology & Medicine, 22(4), 593-596.
- 16. Baumgart, J., Wisniewski, H.G., Amlacher, R., Zhukovaskaya, N.V., Rentz, E., 1989, Age De-pendent Antileukemic Action and Supression of Immune Respanse by 1,4-Benzoquinnone-Guanylhydrazone-Thiosemicarbazone (Ambazo-ne) in Mice, Neoplazma, 36 (4), 393-400.
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- 18. Turzicka E., Vecka M, Stankova B., Zak A., 2002 Analysis of Fatty Acids in Plasma Lipopro-teins by Gas Chromatography-flame ianization Decetron Quantitative Aspects, Analytica Che-mica Acta, 465:-337-50.
- 19. Ntambi JM., 1999. Regulation of Stearoyl-CoA Desaturase by Polyunsaturated Fatty Acids and cholesterol. Journal of Lipid Research 40 (9) : 1549-58.
Year 2008,
Volume: 7 Issue: 1, 183 - 186, 30.11.2008
Abstract
References
- 1. Sies, H., 1986, Biochemistry of Oxidative Stres, Angew, Chem. Int. Ed. Engl.; 25, 1058-1071.
- 2. Finch, R.A., Liu, M., Grill, S.P., Rose, W.C., Loomis, R., Vasquez, K.M., Cheng, Y., Sartorel-li, A.C., 2000, Triapine (3-Aminopyridine-2-Carboxaldehyde-Thiosemicarbazone): A Potent İnhibitor of Ribonucleotide Reductase Activity With Broad Spectrum Antitumor Activity. Bioc-hem. Pharmacol., 15-59(8):983-991.
- 3. Liu, M.C., Lin, T.S., Sartorelli, A.C., 1992, Synthesis And Antitumor Activity Of Amino Derivatives Of Pyridine-2-Carboxaldehyde Thiosemicarbazone, J. Med. Chem., 35 (20) : 3672-7.
- 4. Slater, T.F., 1982, Lipid Peroxidation. Bioche-mical Society Transactions, 10, 70-71.
- 5. Erden, M.,1992, Radyasyonun Bazı Eritrosit En-zimlerine Etkisi, Tr.J of Medical Sciences, 16, 55-66.
- 6. Masotti, L, Casali, E, Gesmundo N., Sartor, G, Cavatorta, P., Borello S., Galeotti, T., 1989, Li-pid Peroxidation and Physical Properties of Smooth and Rough Hepatoma Micromes., Celi. Biophys. 14 (l): 53-65.
- 7. Gözükara, E.M., 1994, Biyokimya 2, 2. Baskı, Evin Matbaası, Malatya.
- 8. Clemens, M.R., 1991, Free Radicals in Chemical Carcinogenesis, Klin Wochenshr; 69, 1123-1134.
- 9. Chapman, J.M., Delucy, P., Wong, O.T., Hail, I.H., 1990, Lipids, 25 (7), 391-397.
- 10. Papageorgiou, Z-, lakovidou, D.M., Mioglou, E. ve diğ., 1997, Anticancer Research, 17,247-252.
- 11. Liu, C.M., Lin, T.S., Sartorelli, A.C., 1992, J. Med. Chem., 35, 3672-3677.
- 12. Çukurovali, A., Yılmaz, İ., Polish J. of Che-mistry., 74, 147 (2000).
- 13. Christie, W.W., 1990, Gas Chromatography and Lipids, The Oil Press, Glasgow., 302-320.
- 14. Machlin L. Bendich A., 1987, Free Radical Tissue Damage: Protective Role of Antioxidant Nutrients, FASEB J. 1:441-45.
- 15. Jain, S.K. and Palmer, M., 1997, The Effect of Oxygen Radicals Metabolites and Vitamin E on Glycosylation of Proteins, Free Radical Biology & Medicine, 22(4), 593-596.
- 16. Baumgart, J., Wisniewski, H.G., Amlacher, R., Zhukovaskaya, N.V., Rentz, E., 1989, Age De-pendent Antileukemic Action and Supression of Immune Respanse by 1,4-Benzoquinnone-Guanylhydrazone-Thiosemicarbazone (Ambazo-ne) in Mice, Neoplazma, 36 (4), 393-400.
- 17. Kostner, G., Ott, I.K., Jauhiainen, M., Enholm, C., Esterbaver, H., 1995, Human Plasma Phospholipids Transfer Protein Accellerates, Biochem.J., 305;659-667.
- 18. Turzicka E., Vecka M, Stankova B., Zak A., 2002 Analysis of Fatty Acids in Plasma Lipopro-teins by Gas Chromatography-flame ianization Decetron Quantitative Aspects, Analytica Che-mica Acta, 465:-337-50.
- 19. Ntambi JM., 1999. Regulation of Stearoyl-CoA Desaturase by Polyunsaturated Fatty Acids and cholesterol. Journal of Lipid Research 40 (9) : 1549-58.
There are 19 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | November 30, 2008 |
| Published in Issue | Year 2008 Volume: 7 Issue: 1 |