Abstract
Myofibromas are rare benign tumors of myofibroblasts, seen more commonly in children. These tumors typically involve soft tissues with a predilection for the head and neck. Malignant neoplasia is often suspected for these rapidly growing tumors in early childhood. Clinical and radiological findings are not typical, and histopathological examination makes the definitive diagnosis. This pathology requires the intervention of a multidisciplinary team and regular follow-up. We report our experience with two children with myofibromas, one in the right arm of a 5-year-old girl and the other in the right axilla of a 9-year-old boy. Tumors were totally resected in both children, who are under follow-up with no adjuvant treatment free of disease after surgery. Myofibroma should be considered in the differential diagnosis of pediatric soft tissue tumors. Surgical resection is sufficient for treatment and patients should be followed regularly for possible recurrences.
Ethical Statement
Since our study was a case report, no application was made for ethics committee approval. However, parents and patients were informed about the purpose of the case report and informed consent was obtained from both families for this publication.
References
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- 2. Wu W, Chen J, Cao X, Yang M, Zhu J, Zhao G. Solitary infantile myofibromatosis in the bones of the upper extremities: Two rare cases and a review of the literature. Oncol Lett. 2013;6(5):1406-1408. doi: 10.3892/ol.2013.1584.
- 3. Abujarir R, Salama H, Alsulaiti G, et al. Congenital scalp myofibroma: a case report. J Neonatal Perinat Med 2011;4(1):75-78.
- 4. Choi JH, Ro JY. The 2020 WHO classification of tumors of soft tissue: selected changes and new entities. Adv Anat Pathol. 2021;28(1):44-58. doi: 10.1097/PAP.0000000000000284.
- 5. Ogita A, Ansai SI. Infantile myofibroma: case report and review of the literature. J Nippon Med Sch. 2021;87(6):355-358. doi: 10.1272/jnms.JNMS.2020_87-609.
- 6. Dhupar A, Carvalho K, Sawant P, Spadigam A, Syed S. Solitary intra-osseous myofibroma of the jaw: a case report and review of literature. Children (Basel). 2017;4(10):91. doi: 10.3390/children4100091.
- 7. Oudijk L, den Bakker MA, Hop WC, et al. Solitary, multifocal and generalized myofibromas: clinicopathological and immunohistochemical features of 114 cases. Histopathology. 2012;60(6B):E1-11. doi: 10.1111/j.1365-2559.2012.04221.x.
- 8. Oztürk O, Tutkun A. A case report of a malignant peripheral nerve sheath tumor of the oral cavity in neurofibromatosis type 1. Case Rep Otolaryngol. 2012;2012:936735. doi: 10.1155/2012/936735.
- 9. Davies BM, du Plessis D, Gnanalingham KK. Myofibroma of the cervical spine presenting as brachialgia. J Neurosurg Spine. 2014;21(6):916-918. doi: 10.3171/2014.8.SPINE131194.
- 10. Madhuri BK, Tripathy D, Mittal R. Solitary orbital myofibroma in a child: A rare case report with literature review. Indian J Ophthalmol. 2019;67(7):1240-1245. doi: 10.4103/ijo.IJO_1553_18.
Abstract
References
- 1. Mahajan P, Hicks J, Chintagumpala M, Venkatramani R. Myofibroma in infancy and childhood. J Pediatr Hematol Oncol. 2017;39(3):e136-e139. doi: 10.1097/MPH.0000000000000732.
- 2. Wu W, Chen J, Cao X, Yang M, Zhu J, Zhao G. Solitary infantile myofibromatosis in the bones of the upper extremities: Two rare cases and a review of the literature. Oncol Lett. 2013;6(5):1406-1408. doi: 10.3892/ol.2013.1584.
- 3. Abujarir R, Salama H, Alsulaiti G, et al. Congenital scalp myofibroma: a case report. J Neonatal Perinat Med 2011;4(1):75-78.
- 4. Choi JH, Ro JY. The 2020 WHO classification of tumors of soft tissue: selected changes and new entities. Adv Anat Pathol. 2021;28(1):44-58. doi: 10.1097/PAP.0000000000000284.
- 5. Ogita A, Ansai SI. Infantile myofibroma: case report and review of the literature. J Nippon Med Sch. 2021;87(6):355-358. doi: 10.1272/jnms.JNMS.2020_87-609.
- 6. Dhupar A, Carvalho K, Sawant P, Spadigam A, Syed S. Solitary intra-osseous myofibroma of the jaw: a case report and review of literature. Children (Basel). 2017;4(10):91. doi: 10.3390/children4100091.
- 7. Oudijk L, den Bakker MA, Hop WC, et al. Solitary, multifocal and generalized myofibromas: clinicopathological and immunohistochemical features of 114 cases. Histopathology. 2012;60(6B):E1-11. doi: 10.1111/j.1365-2559.2012.04221.x.
- 8. Oztürk O, Tutkun A. A case report of a malignant peripheral nerve sheath tumor of the oral cavity in neurofibromatosis type 1. Case Rep Otolaryngol. 2012;2012:936735. doi: 10.1155/2012/936735.
- 9. Davies BM, du Plessis D, Gnanalingham KK. Myofibroma of the cervical spine presenting as brachialgia. J Neurosurg Spine. 2014;21(6):916-918. doi: 10.3171/2014.8.SPINE131194.
- 10. Madhuri BK, Tripathy D, Mittal R. Solitary orbital myofibroma in a child: A rare case report with literature review. Indian J Ophthalmol. 2019;67(7):1240-1245. doi: 10.4103/ijo.IJO_1553_18.
Details
| Primary Language | English |
|---|---|
| Subjects | Pediatric Hematology and Oncology, Clinical Oncology |
| Journal Section | Case Reports |
| Authors | |
| Early Pub Date | January 1, 2024 |
| Publication Date | May 4, 2024 |
| Submission Date | November 9, 2023 |
| Acceptance Date | December 19, 2023 |
| Published in Issue | Year 2024 Volume: 10 Issue: 3 |
