Research Article
Parkinson Hastalığının Tedavisinde Kullanılan Levodopa ve Benserazid Etken Maddelerinin Kemometrik Tayini
Abstract
Bu çalışmada, Parkinson hastalığının tedavisinde kullanılan ilaç numunesindeki levodopa ve benserazid maddelerinin spektrofotometrik olarak kemometrik metotlarla tayini gerçekleştirilmiştir. Deneysel çalışmada maddelerin spektrofotometrik özellikleri belirlendikten sonra her bir maddenin uygun oranlarıyla karıştırılmasıyla yapay karışımların spektrum verileri incelenmiştir. En son aşamada tablet numunesi analizi yapılmıştır. Kemometrik yöntemlerden, temel bileşen regresyonu yöntemi (PCR) ve kısmi en küçük kareler yöntemi (PLS), sentetik karışım ve tablet numunesindeki miktar tayininde başarı ile uygulanmıştır. Hesaplanan veriler, istatistik olarak incelendiklerinde hem hesaplanan geri kazanım değerleri yüksek hem de standart sapmalar yeterince küçüktür. Uygulanan kemometrik yöntemler yardımıyla elde edilen sonuçlar son derece hızlı, basit ve güvenilir sonuçlardır.
Keywords
Supporting Institution
SÜLEYMAN DEMİREL ÜNİVERSİTESİ BİLİMSEL ARAŞTIRMA PROJELERİ
Project Number
FYL-2018-6859
Thanks
Bu çalışma, Süleyman Demirel Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi tarafından “FYL-2018-6859” kodlu proje ile desteklenmiştir.
References
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- Aktaş, A.H., Sarıdağ A.M. 2017. "Liquid chromatografic-chemometric tecnhniques for the simultaneous HPLC determination of lansoprazole, amoksisilin and clarithromisin in commercial preparation". Journal of Chromatografic Science, 1-7.
- Armbruster, D.A., Pty T. 2008." Limit of blank, limit of detection and limit of quantitation" . Clin Biochem Rev, 29, 49-52.
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- Dinç, E. 2009. "Kemometrik İşlem ve Yöntemlerin Analitik Kimyadaki Tipik Uygulamaları". Uygulamalı Kemometri Yaz Okulu Notları, 13-17.
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- Kaur, K., Malik, A.K., Singh, B., Godarzi, M. 2009. "Simultaneous spectrophotometric determination of carbidopa and levodopa by partial least squares regression, principal component regression and least squares support vector machine methods". Thai J.Pharm.Sci., 33, 123- 136.
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- Miao J., Forget, B., Smith, K. 2018. "Predicting Correlation Coefficients for Monte Carlo Eigenvalue Simulations With Multitype Branching Process" . Annals of Nuclear Energy, 112, 307-321.
- Muzzi, C., Bertocci, E., Terzuoli, L., Porcelli, B., Ciari, I., Pagani, R., Guerranti, R. 2008. "Simultaneous determination of serum concentration of levodopa, dopamine, 3-O-methyldopa and alpha-methyldopa by HPLC". Biomedicine & Pharmacotherapy, 62(4), 253-258.
- Nagaraja, P., Vasantha, R.A., Sunitha, K.R., 2001. "A sensitive and selective spectrophotometric estimation of catechol derivatives in pharmaceutical preparations". Talanta, 55, 1039- 1046.
- Porfire, A., Muntean D., Achim M, Vlase L, Tomuta I, 2015. Simultaneous Quantification of Simvastatin and Excipients in Liposomes Using Near Spectroscopy and Chemometry. Journal of Pharmaceutical and Biomedical Analysis, 107: 40-49.
- Rabinca AA, Bulendra M, Tache F, Mihailciuc C, Ciobanu AM, Stefanescu DC, Ciucu AA, 2017. Voltametric method for simultaneous determination of L-dopa and benserazide. Current Analytical Chemistry, 13(3): 218-224.
- Savan Kuyumcu E, Erdoğdu G, 2017. Simultaneous determination of levodopa and benserazide using poly(3-methylthiophene) and a multi-walled carbon nanotube sensor. Journal of Solid State Electrochemistry, 21(8): 2209-2217.
- Sharma D, Singh R, Garg R, 2017. Development and validation of stability indicating UV spectro-photometric method for the estimation of benzydamine hydrochloride in bulk and in pharmaceutical dosage form: a novel analytical technique for conducting in-vitro quality control tests. International Journal Of Pharmaceutical Sciences And Research, 9(2): 678-686.
- Shonhi-Kalkhoran M, Faridbod F, Norouzi P, Ganjali MR, 2018. Praseodymium molybdate nanoplates/reduced graphene oxide nanocomposite based electrode for simultaneous electrochemical determination of entacapone, levodopa and carbidopa. Journal of Materials Science: Materials in Electronics, 29(1): 20-31.
- Shrivastava A, Gupta VB, 2011. Methods for the determination of limit of detection and limit of quantitation of the analytical methods. Chronicles of Young Scientist, 2 (1): 21-25. Sima IA, Naşçu-Briciu RD, Sarbu C, 2013. Simultaneous determination of levodopa and carbidopa in pharmaceuticals by principal component regression. Revue Roumaine de Chimie, 58(7-8): 705-710.
- Tarhan I, Kara AAIH, 2017. Quantitative Determination of Free Fatty Acids in Extra Virgin Olive Oils by Multivariate Methods and Fourier Transform Infrared Spectroscopy Considering Different Absorption Modes. International Journal of Food Properties, 1-8.
- Uslu B, Özkan SA, 2002. Determination of binary mixtures of levodopa and benserazide in pharmaceuticals by ratio-spectra derivative spectrophotometry. Analytical Letters, 35(2): 303-314.
- Uyanık A, 2012. Analitik Kimyacılar İçin İstatistik ve Kemometri. Pegem Akademi Yayıncılık, 6. Baskı: 254-259.
- Wollmer E, Klein S, 2017. Development and validation of a robust and efficient HPLC method for the simultaneous quantificiation of levodopa, carbidopa, benserazide and entacapone in complex matrices. Journal of Pharmaceutical and Biomedical Analysis, 20: 258-269.
- Yongnian N, Gong X, 1997. Simultaneous Spectrophotometric Determination of Mixtures of Food Colorants. Analytica Chimica Acta, 354: 163-171.
- Zapata-Urzua C, Perez-Ortiz M, Bravo M, Olivieri AC, Alvarez-Lueje A, 2010. Simultaneous voltametric determination of levodopa, carbidopa and benserazide in pharmaceuticals using multivariate calibration. Talanta, 82: 962- 968.
Year 2020,
Volume: 13 Issue: 2, 669 - 676, 31.08.2020
Abstract
Project Number
FYL-2018-6859
References
- Ahmad, M.Z., Hamid K.A., Effendi T.J.B. 2012. "A validated high-performance liquid chromatgraphic method for the determination of levodopa in rat plasma & its application in pharmacokinetic studies". IEEE Symposium on Business, Engineering and Industrial Applications, 134-139.
- Aktaş, A.H., Sarıdağ A.M. 2017. "Liquid chromatografic-chemometric tecnhniques for the simultaneous HPLC determination of lansoprazole, amoksisilin and clarithromisin in commercial preparation". Journal of Chromatografic Science, 1-7.
- Armbruster, D.A., Pty T. 2008." Limit of blank, limit of detection and limit of quantitation" . Clin Biochem Rev, 29, 49-52.
- Aslan, S.N., Karahalil B. 2019. "Oksidatif stres ve Parkinson hastalığı". Ankara Ecz., Fak., Derg., 43(1), 94-116.
- Culzoni, M.J., Goicoechea, H.C., Ibanez, G.A., Lozano, V.A., Marsili, N.R., Olivieri, A.C., Pagani, A.P. 2008. "Second-order advantage from kinetic-spectroscopic data matrices in the presence of extreme spectral overlapping A multivariate curve resolution-Alternating least-squares approach". Analytica Chimica Acta, 614, 46-57.
- Demircigil, B.T., Doğan-Topal B., Özkan S.A. 2011. "Simultaneous determination of L-dopa and benserazide in binary mixtures using first derivative of the ratio-voltammetric methods based on their oxidation on solid electrode". Collect. Czech. Chem. Commun., 76, 1717-1736.
- Dinç, E. 2009. "Kemometrik İşlem ve Yöntemlerin Analitik Kimyadaki Tipik Uygulamaları". Uygulamalı Kemometri Yaz Okulu Notları, 13-17.
- Dinç, E., Kaya, S., Doğanay, T. 2007. "Continuous wavelet and derivative transforms for the simultaneous quantitative analysis and dissolution test of levodopa-benserazide tablets". Journal of Pharmaceutical and Biomedical Analysis, 44, 991- 995.
- Kaur, K., Malik, A.K., Singh, B., Godarzi, M. 2009. "Simultaneous spectrophotometric determination of carbidopa and levodopa by partial least squares regression, principal component regression and least squares support vector machine methods". Thai J.Pharm.Sci., 33, 123- 136.
- Madrakian, T., Mohammadnejad, M. 2007. "Simultaneous spectrophotometric determination of levodopa and carbidopa in pharmaceutical formulations and water samples by using mean centering of ratio spectra and H-point standard addition methods". Chem. Pharm. Bull., 55(6), 865-870.
- Miao J., Forget, B., Smith, K. 2018. "Predicting Correlation Coefficients for Monte Carlo Eigenvalue Simulations With Multitype Branching Process" . Annals of Nuclear Energy, 112, 307-321.
- Muzzi, C., Bertocci, E., Terzuoli, L., Porcelli, B., Ciari, I., Pagani, R., Guerranti, R. 2008. "Simultaneous determination of serum concentration of levodopa, dopamine, 3-O-methyldopa and alpha-methyldopa by HPLC". Biomedicine & Pharmacotherapy, 62(4), 253-258.
- Nagaraja, P., Vasantha, R.A., Sunitha, K.R., 2001. "A sensitive and selective spectrophotometric estimation of catechol derivatives in pharmaceutical preparations". Talanta, 55, 1039- 1046.
- Porfire, A., Muntean D., Achim M, Vlase L, Tomuta I, 2015. Simultaneous Quantification of Simvastatin and Excipients in Liposomes Using Near Spectroscopy and Chemometry. Journal of Pharmaceutical and Biomedical Analysis, 107: 40-49.
- Rabinca AA, Bulendra M, Tache F, Mihailciuc C, Ciobanu AM, Stefanescu DC, Ciucu AA, 2017. Voltametric method for simultaneous determination of L-dopa and benserazide. Current Analytical Chemistry, 13(3): 218-224.
- Savan Kuyumcu E, Erdoğdu G, 2017. Simultaneous determination of levodopa and benserazide using poly(3-methylthiophene) and a multi-walled carbon nanotube sensor. Journal of Solid State Electrochemistry, 21(8): 2209-2217.
- Sharma D, Singh R, Garg R, 2017. Development and validation of stability indicating UV spectro-photometric method for the estimation of benzydamine hydrochloride in bulk and in pharmaceutical dosage form: a novel analytical technique for conducting in-vitro quality control tests. International Journal Of Pharmaceutical Sciences And Research, 9(2): 678-686.
- Shonhi-Kalkhoran M, Faridbod F, Norouzi P, Ganjali MR, 2018. Praseodymium molybdate nanoplates/reduced graphene oxide nanocomposite based electrode for simultaneous electrochemical determination of entacapone, levodopa and carbidopa. Journal of Materials Science: Materials in Electronics, 29(1): 20-31.
- Shrivastava A, Gupta VB, 2011. Methods for the determination of limit of detection and limit of quantitation of the analytical methods. Chronicles of Young Scientist, 2 (1): 21-25. Sima IA, Naşçu-Briciu RD, Sarbu C, 2013. Simultaneous determination of levodopa and carbidopa in pharmaceuticals by principal component regression. Revue Roumaine de Chimie, 58(7-8): 705-710.
- Tarhan I, Kara AAIH, 2017. Quantitative Determination of Free Fatty Acids in Extra Virgin Olive Oils by Multivariate Methods and Fourier Transform Infrared Spectroscopy Considering Different Absorption Modes. International Journal of Food Properties, 1-8.
- Uslu B, Özkan SA, 2002. Determination of binary mixtures of levodopa and benserazide in pharmaceuticals by ratio-spectra derivative spectrophotometry. Analytical Letters, 35(2): 303-314.
- Uyanık A, 2012. Analitik Kimyacılar İçin İstatistik ve Kemometri. Pegem Akademi Yayıncılık, 6. Baskı: 254-259.
- Wollmer E, Klein S, 2017. Development and validation of a robust and efficient HPLC method for the simultaneous quantificiation of levodopa, carbidopa, benserazide and entacapone in complex matrices. Journal of Pharmaceutical and Biomedical Analysis, 20: 258-269.
- Yongnian N, Gong X, 1997. Simultaneous Spectrophotometric Determination of Mixtures of Food Colorants. Analytica Chimica Acta, 354: 163-171.
- Zapata-Urzua C, Perez-Ortiz M, Bravo M, Olivieri AC, Alvarez-Lueje A, 2010. Simultaneous voltametric determination of levodopa, carbidopa and benserazide in pharmaceuticals using multivariate calibration. Talanta, 82: 962- 968.
There are 25 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Engineering |
| Journal Section | Makaleler |
| Authors | |
| Project Number | FYL-2018-6859 |
| Publication Date | August 31, 2020 |
| Published in Issue | Year 2020 Volume: 13 Issue: 2 |