Research Article
Year 2024,
Volume: 3 Issue: 1, 21 - 30, 30.04.2024
Abstract
Lupeol compound is a cyclic triterpene alcohol that is widely found in plants. The compound lupeol has been reported to exhibit antitumor, anti-inflammatory, anxiolytic, neuroprotective and hepatoprotective effects. Recent research shows that lupeol could be a potential medicine for various diseases and also an adjuvant for intractable diseases. Cancer poses a health threat that is increasingly common around the world. Among new cancer cases, lung cancer is one of the most common and deadly cancers worldwide. In this study, the anticancer efficiency of lupeol on human lung adenocarcinoma A549 and glioma C6 cell lines were examined. Various concentrations of lupeol (500, 250, 125, 62.5, 31.25, 15.62, 7.81, 3.90 μM) effectually reduced cell viability in the A549 and C6 cell lines in a dose-dependent manner. These results showed that lupeol had selective anticancer activity against A549 and C6 cell lines.
Keywords
References
- Abdelrahim MS, Abdel-Baky AM, Bayoumi SAL, Mohamed SM, Abdel-Mageed WM, Backheet EY. Cytotoxic flavone-C-glycosides from the leaves of Dypsis pembana (H.E.Moore) Beentje & J.Dransf, Arecaceae: in vitro and molecular docking studies. BMC Complementary Medicine and Therapies. (2023); 23:214. https://doi.org/10.1186/s12906-023-04046-0
- Mattiuzzi C, Lippi G. Current cancer epidemiology, Journal of Epidemiology Global Health (2019);9(4):217–222. https://doi.org/10.2991/jegh.k.191008.001
- Lu J, Feng Y, Guo K, Sun L, Ruan S, Zhang K. Prognostic value of preoperative circulating tumor DNA in non-small cell lung cancer: a systematic review and meta-analysis. Journal of Cancer Research and Clinical Oncology. (2024);150(1):25. https://doi.org/10.1007/s00432-023-05550-z
- Zhu L, Qin J. Predictive biomarkers for immunotherapy response in extensive-stage SCLC, Journal of Cancer Research and Clinical Oncology. (2024);150(1):22. https://doi.org/10.1007/s00432-023-05544-x
- Islam A, Rahat I, Anurag, Rejeeth C, Sharma D, Sharma A. Recent advcances on plant-based bioengineered nanoparticles using secondary metabolites and their potential in lung cancer management. Journal of Future Foods. (2025);5(1):1–20. https://doi.org/10.1016/j.jfutfo.2024.01.001
- Giakoumettis D, Kritis A, Foroglou N. C6 cell line: the gold standard in glioma research. Hippokratia. (2018);22(3):105-112.
- Shao G, Liu Y, Lu L, Wang L, Ji G, Xu H. Therapeutic potential of traditional Chinese medicine in the prevention and treatment of digestive inflammatory cancer transformation: Portulaca oleracea L. as a promising drug. Journal of Ethnopharmacology. (2024);327:117999. https://doi.org/10.1016/j.jep.2024.117999
- Yan Y, Gagalova KK, Gerbrandt EM, Castellarin SD. Cuticular wax biosynthesis in blueberries (Vaccinium corymbosum L.): Transcript and metabolite changes during ripening and storage affect key fruit quality traits, Horticulture Research. (2024);11(3). https://doi.org/10.1093/hr/uhae004
- Jan S, et al. Unleashed Treasures of Solanaceae: Mechanistic Insights into Phytochemicals with Therapeutic Potential for Combatting Human Diseases. Plants. (2024);13(5):724. https://doi.org/10.3390/plants13050724
- Sun M, et al. Terpenoids derived from Semen Ziziphi Spinosae oil enhance sleep by modulating neurotransmitter signaling in mice. Heliyon. (2024);10(5):e26979. https://doi.org/10.1016/j.heliyon.2024.e26979
- Huang H, He X, Sun Q, Liu G, Tang Y, Sun J. Differential changes in cuticular wax affect the susceptibility to fruit decay in pitaya after harvest: A cultivar comparative study, Postharvest Biology and Technology (2024);210:112751.https://doi.org/10.1016/j.postharvbio.2023.112751
- Guo H, Chen T, Zhu H, Wang H, Huo YX. Engineering amino acid residues of pentacyclic triterpene synthases for improving the activity, Applied Microbiology and Biotechnology. (2024);108:195. https://doi.org/10.1007/s00253-024-13030-8
- Abdel Halim MB, et al. The study of wound healing activity of Thespesia populnea L. bark, an approach for accelerating healing through nanoparticles and isolation of main active constituents, BMC Complementary Medicine and Therapies. (2024);24:85. https://doi.org/10.1186/s12906-024-04343-2
- Ravichandran S, Kandaswamy K, Muthu K. Evaluation of lupeol-chitosan nanoparticles infused cellulose acetate membranes for enhanced in-vitro anticancer and antidiabetic activities. Chemosphere. (2024);351:141149.https://doi.org/10.1016/j.chemosphere.2024.141149
- Qin F, Zhang H, Zhang L, Yao C, Wang S, Zhang Z. Photoimmune synergistic inactivation of colon cancer cells using indocyanine green and lupeol composite liposomes. Zhongguo Jiguang/Chinese Journal of Lasers (2024);51(3). https://doi.org/10.3788/CJL231300
- Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immulogical Methods. (1983);65:55-63. https://doi.org/10.1016/0022-1759(83)90303-4
- Aborehab NM, Salama MM, Ezzat SM. A novel lupene derivative from Thymus capitatus possesses an apoptosis-inducing effect via Let-7 miRNA/Cyclin D1/VEGF cascade in the A549 cell line, BMC Complementary Medicine and Therapies.(2023);23:365. https://doi.org/10.1186/s12906-023-04201-7
- Li W, Hao J, Xiao Y. Synthesis and in vitro antitumor activities of lupeol dicarboxylic acid monoester derivatives. Archives of Pharmacal Research (2013);36(12):1447–1453.https://doi.org/10.1007/s12272-013-0155-x
- Lemes BB, et al. Two new prenylated isoflavones from Deguelia costata, Phytochemistry Letters. (2019);30:181–185. https://doi.org/10.1016/j.phytol.2019.02.018
- Jin Y, et al. Lupeol enhances radiosensitivity of human hepatocellular carcinoma cell line SMMC-7721 in vitro and in vivo. International Journal of Radiation Biology.(2015);91(2), 202–208. https://doi.org/10.3109/09553002.2015.966209
- Yuan Y, Wu J, Li B, Niu J, Tan H, Qiu S. Regulation of signaling pathways involved in the anti-proliferative and apoptosis-inducing effects of M22 against Non-small Cell Lung Adenocarcinoma A549 Cells. Scientific Reports. (2018);8(1):992. https://doi.org/10.1038/s41598-018-19368-0
Year 2024,
Volume: 3 Issue: 1, 21 - 30, 30.04.2024
Abstract
References
- Abdelrahim MS, Abdel-Baky AM, Bayoumi SAL, Mohamed SM, Abdel-Mageed WM, Backheet EY. Cytotoxic flavone-C-glycosides from the leaves of Dypsis pembana (H.E.Moore) Beentje & J.Dransf, Arecaceae: in vitro and molecular docking studies. BMC Complementary Medicine and Therapies. (2023); 23:214. https://doi.org/10.1186/s12906-023-04046-0
- Mattiuzzi C, Lippi G. Current cancer epidemiology, Journal of Epidemiology Global Health (2019);9(4):217–222. https://doi.org/10.2991/jegh.k.191008.001
- Lu J, Feng Y, Guo K, Sun L, Ruan S, Zhang K. Prognostic value of preoperative circulating tumor DNA in non-small cell lung cancer: a systematic review and meta-analysis. Journal of Cancer Research and Clinical Oncology. (2024);150(1):25. https://doi.org/10.1007/s00432-023-05550-z
- Zhu L, Qin J. Predictive biomarkers for immunotherapy response in extensive-stage SCLC, Journal of Cancer Research and Clinical Oncology. (2024);150(1):22. https://doi.org/10.1007/s00432-023-05544-x
- Islam A, Rahat I, Anurag, Rejeeth C, Sharma D, Sharma A. Recent advcances on plant-based bioengineered nanoparticles using secondary metabolites and their potential in lung cancer management. Journal of Future Foods. (2025);5(1):1–20. https://doi.org/10.1016/j.jfutfo.2024.01.001
- Giakoumettis D, Kritis A, Foroglou N. C6 cell line: the gold standard in glioma research. Hippokratia. (2018);22(3):105-112.
- Shao G, Liu Y, Lu L, Wang L, Ji G, Xu H. Therapeutic potential of traditional Chinese medicine in the prevention and treatment of digestive inflammatory cancer transformation: Portulaca oleracea L. as a promising drug. Journal of Ethnopharmacology. (2024);327:117999. https://doi.org/10.1016/j.jep.2024.117999
- Yan Y, Gagalova KK, Gerbrandt EM, Castellarin SD. Cuticular wax biosynthesis in blueberries (Vaccinium corymbosum L.): Transcript and metabolite changes during ripening and storage affect key fruit quality traits, Horticulture Research. (2024);11(3). https://doi.org/10.1093/hr/uhae004
- Jan S, et al. Unleashed Treasures of Solanaceae: Mechanistic Insights into Phytochemicals with Therapeutic Potential for Combatting Human Diseases. Plants. (2024);13(5):724. https://doi.org/10.3390/plants13050724
- Sun M, et al. Terpenoids derived from Semen Ziziphi Spinosae oil enhance sleep by modulating neurotransmitter signaling in mice. Heliyon. (2024);10(5):e26979. https://doi.org/10.1016/j.heliyon.2024.e26979
- Huang H, He X, Sun Q, Liu G, Tang Y, Sun J. Differential changes in cuticular wax affect the susceptibility to fruit decay in pitaya after harvest: A cultivar comparative study, Postharvest Biology and Technology (2024);210:112751.https://doi.org/10.1016/j.postharvbio.2023.112751
- Guo H, Chen T, Zhu H, Wang H, Huo YX. Engineering amino acid residues of pentacyclic triterpene synthases for improving the activity, Applied Microbiology and Biotechnology. (2024);108:195. https://doi.org/10.1007/s00253-024-13030-8
- Abdel Halim MB, et al. The study of wound healing activity of Thespesia populnea L. bark, an approach for accelerating healing through nanoparticles and isolation of main active constituents, BMC Complementary Medicine and Therapies. (2024);24:85. https://doi.org/10.1186/s12906-024-04343-2
- Ravichandran S, Kandaswamy K, Muthu K. Evaluation of lupeol-chitosan nanoparticles infused cellulose acetate membranes for enhanced in-vitro anticancer and antidiabetic activities. Chemosphere. (2024);351:141149.https://doi.org/10.1016/j.chemosphere.2024.141149
- Qin F, Zhang H, Zhang L, Yao C, Wang S, Zhang Z. Photoimmune synergistic inactivation of colon cancer cells using indocyanine green and lupeol composite liposomes. Zhongguo Jiguang/Chinese Journal of Lasers (2024);51(3). https://doi.org/10.3788/CJL231300
- Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immulogical Methods. (1983);65:55-63. https://doi.org/10.1016/0022-1759(83)90303-4
- Aborehab NM, Salama MM, Ezzat SM. A novel lupene derivative from Thymus capitatus possesses an apoptosis-inducing effect via Let-7 miRNA/Cyclin D1/VEGF cascade in the A549 cell line, BMC Complementary Medicine and Therapies.(2023);23:365. https://doi.org/10.1186/s12906-023-04201-7
- Li W, Hao J, Xiao Y. Synthesis and in vitro antitumor activities of lupeol dicarboxylic acid monoester derivatives. Archives of Pharmacal Research (2013);36(12):1447–1453.https://doi.org/10.1007/s12272-013-0155-x
- Lemes BB, et al. Two new prenylated isoflavones from Deguelia costata, Phytochemistry Letters. (2019);30:181–185. https://doi.org/10.1016/j.phytol.2019.02.018
- Jin Y, et al. Lupeol enhances radiosensitivity of human hepatocellular carcinoma cell line SMMC-7721 in vitro and in vivo. International Journal of Radiation Biology.(2015);91(2), 202–208. https://doi.org/10.3109/09553002.2015.966209
- Yuan Y, Wu J, Li B, Niu J, Tan H, Qiu S. Regulation of signaling pathways involved in the anti-proliferative and apoptosis-inducing effects of M22 against Non-small Cell Lung Adenocarcinoma A549 Cells. Scientific Reports. (2018);8(1):992. https://doi.org/10.1038/s41598-018-19368-0
There are 21 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Pharmacology and Pharmaceutical Sciences (Other) |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | April 30, 2024 |
| Submission Date | April 7, 2024 |
| Acceptance Date | April 22, 2024 |
| Published in Issue | Year 2024 Volume: 3 Issue: 1 |
