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Oküler Dokularda Oksidatif Stres ve Potasyum İyonunun (K+) Tetiklediği Hastalıklarda Erken Teşhis İmkâni Sağlayan Kontakt Lens

Year 2024, Volume: 12 Issue: 2, 631 - 641, 29.04.2024

Yaşar Şen

https://doi.org/10.29130/dubited.1352248

Abstract

Çalışmada, bir doktorun yerini alabilecek bir lens tasarlamak için sensör teknolojisi kullanıldı. Erken teşhis için silikon hidrojel lens olan Lotrafilcon A üzerine yerleştirilecek oksidatif stres sensörü, (K+) iyon sensörü ve basınç sensörünün yanı sıra kullanıcının kendi başına kullanabileceği bir kayıt ve görüntüleme cihazından oluşur, 24 saat kayıt yapar ve gerekirse uyarı verir. Ek olarak, harici bir kablosuz güç aktarım cihazı aracılığıyla veri iletimi için sensörlere güç sağlanacaktır. Kullanılan oksidatif stres sensörü ile göz yapılarında oksidatif stres saptanır, hastada diyabetik retinopati, glokom ve katarakt için anormal bir durumun ortaya çıkabileceği anlaşılır. Aynı şekilde (K +) iyon sensörü de oküler hücrelerdeki (K +) iyon konsantrasyonunu tespit eder, konsantrasyonun arttığı anormal durumları tespit eder. Kullanılacak basınç sensörü ile glokom tanısı alan hastaların basıncı kontrol altında tutulur. Oluşabilecek hastalıkların erken teşhisi, eğer bir hastalık varsa hastalığın sürekli izlenmesi ve kontrolü sağlanacaktır. Bu, kullanıcının sürekli hastaneye gitmesini önlerken aynı zamanda iş yükünü de azaltacaktır.

Keywords

Katarakt Kontakt lens Diyabetik retinopati Migren Oksidatif stres Potasyum iyon (K+) sensörü

References

  • [1] Hunkyu Seo, Won Gi Chung, Yong Won Kwon, Sumin Kim, Yeon-Mi Hong, Wonjung Park, Enji Kim, Jakyoung Lee, Sanghoon Lee, Moohyun Kim, Kyeonghee Lim, Inhea Jeong, Hayoung Song, and Jang-Ung Park, “Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management”, Chem. Rev. vol.123, no19, pp 11488−11558, 2023
  • [2] Shirzaei Sani, E. Xu, C. Wang, C. Song, Y. Min, J. Tu, J. Solomon, S. A. Li, J. Banks, J. L. Armstrong, D. G. Gao, W. “ A Stretchable Wireless Wearable Bioelectronic System for Multiplexed Monitoring and Combination Treatment of Infected Chronic Wounds”. Science Advances, 2023. 9 (12), No. eadf7388,
  • [3] Wang, M.; Yang, Y.; Min, J.; Song, Y.; Tu, J.; Mukasa, D.; Ye, C.; Xu, C.; Heflin, N.; McCune, J. S.; Hsiai, T. K.; Li, Z.; Gao, W. A “Wearable Electrochemical Biosensor for the Monitoring of Metabo-lites and Nutrients”. Nat. Biomed. Eng. 2022, 6 (11), 1225−1235.
  • [4] De la Paz, E.; Maganti, N. H.; Trifonov, A.; Jeerapan, I.; Mahato, K.; Yin, L.; Sonsa-ard, T.; Ma, N.; Jung, W.; Burns, R.; Zarrinpar, A.; Wang, J.; Mercier, P. P. A “Self-Powered Ingestible Wireless Biosensing System for Real-Time in Situ Monitoring of Gastrointestinal Tract Metabolites”. Nat. Commun. 2022, 13 (1), 7405.
  • [5] Song, J. W.; Ryu, H.; Bai, W.; Xie, Z.; Vázquez-Guardado, A.; Nandoliya, K.; Avila, R.; Lee, G.; Song, Z.; Kim, J.; Lee, M.-K.; Liu, Y.; Kim, M.; Wang, H.; Wu, Y.; Yoon, H.-J.; Kwak, S. S.; Shin, J.; Kwon, K.; Lu, W.; Chen, X.; Huang, Y.; Ameer, G. A.; Rogers, J. A. “Bioresorbable, Wireless, and Battery-Free System for Electrotherapy and Impedance Sensing at Wound Sites”. Science Advances 2023, 9 (8), No. eade4687.
  • [6] Jiang, Y.; Trotsyuk, A. A.; Niu, S.; Henn, D.; Chen, K.; Shih, C.-C.; Larson, M. R.; Mermin Bunnell, A. M.; Mittal, S.; Lai, J.-C.; Saberi, A.; Beard, E.; Jing, S.; Zhong, D.; Steele, S. R.; Sun, K.; Jain, T.; Zhao, E.; Neimeth, C. R.; Viana, W. G.; Tang, J.; Sivaraj, D.; Padmanabhan, J.; Rodrigues, M.; Perrault, D. P.; Chattopadhyay, A.; Maan, Z. N.; Leeolou, M. C.; Bonham, C. A.; Kwon, S. H.; Kussie, H. C.; Fischer, K. S.; Gurusankar, G.; Liang, K.; Zhang, K.; Nag, R.; Snyder, M. P.; Januszyk, M.; Gurtner, G. C.; Bao, Z. “Wireless, Closed-Loop, Smart Bandage with Integrated Sensors and Stimulators for Advanced Wound Care and Accelerated Healing”. Nat. Biotechnol. 2023, 41 (5), 652−662.
  • [7] An, B. W.; Shin, J. H.; Kim, S.-Y.; Kim, J.; Ji, S.; Park, J.; Lee, Y.; Jang, J.; Park, Y.-G.; Cho, E.; Jo, S.; Park, J.-U. “Smart Sensor Systems for Wearable Electronic Devices”. Polymers 2017, 9 (8), 303.
  • [8] Grace E Dunbar Bailey Yuguan Shen Ahmad A Aref . “The Sensimed Triggerfish contact lens sensor: efficacy, safety, and patient perspectives”. Clinical Ophthalmology 2017:11 875–882 8 May 2017
  • [9] Renu Agarwal, Igor Iezhitsa, Puneet Agarwal, Alexander Spasov, “Magnesium deficiency: Does it have a role to play in cataractogenesis?”, Experimental Eye Research 101 (2012) 82-89.
  • [10] Bara M, Guiet-Bara A, Durlach J (1993) “Regulation of sodium and potassium pathways by magnesium in cell membranes.” Magnes Res 6(2):167–177
  • [11] Iezhitsa IN (2005) “Potassium and magnesium depletions in congestive heart failure– pathophysiology, consequences and replenishment.” Clin Calcium 15(11):123–133
  • [12] Renu Agarwal, lgor Iezhitsa, Puneet Agarwal, “Pathogenetic role of magnesium deficiency in ophthalmic diseases”, Biometals (2014) 27:5–18
  • [13] Azza Dammak, Cristina Pastrana, Alba Martin-Gil, Carlos Carpena-Torres, Assumpta Peral Cerda, Mirjam Simovart, Pilar Alarma, Fernando Huete-Toral and Gonzalo Carracedo, “Oxidative Stress in the Anterior Ocular Diseases: Diagnostic and Treatment”, Biomedicines 2023, 11, 292.
  • [14] R. A. Moses, “The Goldmann applanation tonometer,” Amer. J. Ophthalmol., vol. 46, no. 6, pp. 865–869, Dec. 1958.
  • [15] K. C. Katuri, S. Asrani, and M. K. Ramasubramanian, “Intraocular pressure monitoring sensors,” IEEE Sensors 1., vol. 8, no. 1, pp. 12 - 19, Jan. 2008.
  • [16] L. Martinez, R. Giannetti, M. Rodriquez, “Design of a system for continuous intraocular pressure monitoring,” In: Instrumentation and Measurement Technology Conference, Como, Italy, 2004.
  • [17] K. C. Katuri, M K. Ramasubramanian, S. Asrani, “ A Surface Micromachined Capacitive Pressure Sensor for Intraocular Pressure Measurement, ” IEEE ASME Int. Conf. on Mechatronics and Embedded Systems and Applications , pp. 149-154, 2010.
  • [18] C. Collin, “Miniature passive pressure transensor for implanting in the eye,” IEEE Transactions on Biomedical Engineering ( Volume: BME-14, Issue: 2, April 1967) Page(s): 74 - 83
  • [19] P. Walter, U Schnakenberg, “Development of a completely encapsulated intraocular pressure sensor,” Ophthalmic Research, vol. 32, no. 26, pp. 278-284, 2000.
  • [20] Internet of Things in Eye Diseases, Introducing a New Smart Eyeglasses Designed for Probable Dangerous Pressure Changes in Human Eyes (2017 International Confarence on Computer and Applications)
  • [21] The National Eye Institute (NEI) (September 2015)
  • [22] Migren Hastalarında Merkezi Kornea Kalınlığın Değerlendirilmesi. Mehmet COŞKUN . Karabük Üniversitesi Göz Hastalıkları Anabilim Dalı, Karabük (Bozok Tıp Derg 2017;7(1):59-63)
  • [23] Coşkun, Mehmet. “Migren Hastalıklarında Merkezi Kornea Kalınlığının Değerlendirmesi ”.www.dergipark.gov.tr.dergipark.gov.tr/article-file/292642 Access Address on March 25, 2019
  • [24] Argus VA: Ocular hypertension and central corneal thickness.Ophthalmology. 1995;102:1810- 1812.
  • [25] Ventura AC, Bohnke M, Mojon DS: “Central corneal thickness measurements in patients with normal tension glaucoma, primary open angle glaucoma, pseudoexfolia tion glaucoma, or ocular hypertension”. Br J Ophthalmol. 2001;85:792-795.
  • [26] Ko Y-C, Liu CJ-I, Hsu W-M: “Varying effects of corneal thickness on intraocular pressure measurements with different tonometers”.Eye. 2005;19:327-332
  • [27] Brandt JD, Beiser JA, Kass MA, et al.: “Central corneal thickness in the Ocular Hypertension Treatment Study (OHTS)”. Ophthalmology. 2001;108:1779-1788.
  • [28] Gordon MO, Baiser JA, Brandt JE, et al.: T”he ocular hypertension treatment study: Baseline factors that predict the onset of primary open-angle glaucoma”. Arch Ophthalmol. 2002;120: 714-720.
  • [29] Hasim, Z,. Zarina, S,. “ Osmatik Stress induced oxidative damage; Possible machansim of cataract formation in diabetes ” Journal of Diabetes and its Compilcations, 2012

Contact Lens that Enabled Early Diagnosis for Diseases Induced by Oxidative Stress and Potassium Ion (K+) in Ocular Tissues

Year 2024, Volume: 12 Issue: 2, 631 - 641, 29.04.2024

Yaşar Şen

https://doi.org/10.29130/dubited.1352248

Abstract

The present study used sensor technology to design a lens that could replace a docto.r It consists of an oxidative stress sensor, a (K+) ion sensor and a pressure sensor placed on a Lotrafilcon A silicone hydrogel lens for early diagnosis, as well as a recording and display device that the user can use on their own, recording 24 hours a day and alerting when needed. Additionally, power will be provided to the sensors for data transmission via an external wireless power transfer device. The oxidative stress sensor detects oxidative stress in the structures of the eye and indicates that the patient may have an abnormal condition like diabetic retinopathy, glaucoma and cataracts. Likewise, the (K +) ion sensor detects the (K +) ion concentration in the ocular cells and detects abnormal conditions where the concentration is elevated. The pressure sensor allows the intraocular pressure of patients diagnosed with glaucoma to be kept under control. This way, diseases can be diagnosed early, and continuous monitoring and control of the disease will be ensured. This will prevent the user from having to make frequent visits to the hospital, while also reducing the workload.

Keywords

Cataract Contact lens Diabetic retinopathy Migraine Oxidative stress Potassium ion (K+) sensor

References

  • [1] Hunkyu Seo, Won Gi Chung, Yong Won Kwon, Sumin Kim, Yeon-Mi Hong, Wonjung Park, Enji Kim, Jakyoung Lee, Sanghoon Lee, Moohyun Kim, Kyeonghee Lim, Inhea Jeong, Hayoung Song, and Jang-Ung Park, “Smart Contact Lenses as Wearable Ophthalmic Devices for Disease Monitoring and Health Management”, Chem. Rev. vol.123, no19, pp 11488−11558, 2023
  • [2] Shirzaei Sani, E. Xu, C. Wang, C. Song, Y. Min, J. Tu, J. Solomon, S. A. Li, J. Banks, J. L. Armstrong, D. G. Gao, W. “ A Stretchable Wireless Wearable Bioelectronic System for Multiplexed Monitoring and Combination Treatment of Infected Chronic Wounds”. Science Advances, 2023. 9 (12), No. eadf7388,
  • [3] Wang, M.; Yang, Y.; Min, J.; Song, Y.; Tu, J.; Mukasa, D.; Ye, C.; Xu, C.; Heflin, N.; McCune, J. S.; Hsiai, T. K.; Li, Z.; Gao, W. A “Wearable Electrochemical Biosensor for the Monitoring of Metabo-lites and Nutrients”. Nat. Biomed. Eng. 2022, 6 (11), 1225−1235.
  • [4] De la Paz, E.; Maganti, N. H.; Trifonov, A.; Jeerapan, I.; Mahato, K.; Yin, L.; Sonsa-ard, T.; Ma, N.; Jung, W.; Burns, R.; Zarrinpar, A.; Wang, J.; Mercier, P. P. A “Self-Powered Ingestible Wireless Biosensing System for Real-Time in Situ Monitoring of Gastrointestinal Tract Metabolites”. Nat. Commun. 2022, 13 (1), 7405.
  • [5] Song, J. W.; Ryu, H.; Bai, W.; Xie, Z.; Vázquez-Guardado, A.; Nandoliya, K.; Avila, R.; Lee, G.; Song, Z.; Kim, J.; Lee, M.-K.; Liu, Y.; Kim, M.; Wang, H.; Wu, Y.; Yoon, H.-J.; Kwak, S. S.; Shin, J.; Kwon, K.; Lu, W.; Chen, X.; Huang, Y.; Ameer, G. A.; Rogers, J. A. “Bioresorbable, Wireless, and Battery-Free System for Electrotherapy and Impedance Sensing at Wound Sites”. Science Advances 2023, 9 (8), No. eade4687.
  • [6] Jiang, Y.; Trotsyuk, A. A.; Niu, S.; Henn, D.; Chen, K.; Shih, C.-C.; Larson, M. R.; Mermin Bunnell, A. M.; Mittal, S.; Lai, J.-C.; Saberi, A.; Beard, E.; Jing, S.; Zhong, D.; Steele, S. R.; Sun, K.; Jain, T.; Zhao, E.; Neimeth, C. R.; Viana, W. G.; Tang, J.; Sivaraj, D.; Padmanabhan, J.; Rodrigues, M.; Perrault, D. P.; Chattopadhyay, A.; Maan, Z. N.; Leeolou, M. C.; Bonham, C. A.; Kwon, S. H.; Kussie, H. C.; Fischer, K. S.; Gurusankar, G.; Liang, K.; Zhang, K.; Nag, R.; Snyder, M. P.; Januszyk, M.; Gurtner, G. C.; Bao, Z. “Wireless, Closed-Loop, Smart Bandage with Integrated Sensors and Stimulators for Advanced Wound Care and Accelerated Healing”. Nat. Biotechnol. 2023, 41 (5), 652−662.
  • [7] An, B. W.; Shin, J. H.; Kim, S.-Y.; Kim, J.; Ji, S.; Park, J.; Lee, Y.; Jang, J.; Park, Y.-G.; Cho, E.; Jo, S.; Park, J.-U. “Smart Sensor Systems for Wearable Electronic Devices”. Polymers 2017, 9 (8), 303.
  • [8] Grace E Dunbar Bailey Yuguan Shen Ahmad A Aref . “The Sensimed Triggerfish contact lens sensor: efficacy, safety, and patient perspectives”. Clinical Ophthalmology 2017:11 875–882 8 May 2017
  • [9] Renu Agarwal, Igor Iezhitsa, Puneet Agarwal, Alexander Spasov, “Magnesium deficiency: Does it have a role to play in cataractogenesis?”, Experimental Eye Research 101 (2012) 82-89.
  • [10] Bara M, Guiet-Bara A, Durlach J (1993) “Regulation of sodium and potassium pathways by magnesium in cell membranes.” Magnes Res 6(2):167–177
  • [11] Iezhitsa IN (2005) “Potassium and magnesium depletions in congestive heart failure– pathophysiology, consequences and replenishment.” Clin Calcium 15(11):123–133
  • [12] Renu Agarwal, lgor Iezhitsa, Puneet Agarwal, “Pathogenetic role of magnesium deficiency in ophthalmic diseases”, Biometals (2014) 27:5–18
  • [13] Azza Dammak, Cristina Pastrana, Alba Martin-Gil, Carlos Carpena-Torres, Assumpta Peral Cerda, Mirjam Simovart, Pilar Alarma, Fernando Huete-Toral and Gonzalo Carracedo, “Oxidative Stress in the Anterior Ocular Diseases: Diagnostic and Treatment”, Biomedicines 2023, 11, 292.
  • [14] R. A. Moses, “The Goldmann applanation tonometer,” Amer. J. Ophthalmol., vol. 46, no. 6, pp. 865–869, Dec. 1958.
  • [15] K. C. Katuri, S. Asrani, and M. K. Ramasubramanian, “Intraocular pressure monitoring sensors,” IEEE Sensors 1., vol. 8, no. 1, pp. 12 - 19, Jan. 2008.
  • [16] L. Martinez, R. Giannetti, M. Rodriquez, “Design of a system for continuous intraocular pressure monitoring,” In: Instrumentation and Measurement Technology Conference, Como, Italy, 2004.
  • [17] K. C. Katuri, M K. Ramasubramanian, S. Asrani, “ A Surface Micromachined Capacitive Pressure Sensor for Intraocular Pressure Measurement, ” IEEE ASME Int. Conf. on Mechatronics and Embedded Systems and Applications , pp. 149-154, 2010.
  • [18] C. Collin, “Miniature passive pressure transensor for implanting in the eye,” IEEE Transactions on Biomedical Engineering ( Volume: BME-14, Issue: 2, April 1967) Page(s): 74 - 83
  • [19] P. Walter, U Schnakenberg, “Development of a completely encapsulated intraocular pressure sensor,” Ophthalmic Research, vol. 32, no. 26, pp. 278-284, 2000.
  • [20] Internet of Things in Eye Diseases, Introducing a New Smart Eyeglasses Designed for Probable Dangerous Pressure Changes in Human Eyes (2017 International Confarence on Computer and Applications)
  • [21] The National Eye Institute (NEI) (September 2015)
  • [22] Migren Hastalarında Merkezi Kornea Kalınlığın Değerlendirilmesi. Mehmet COŞKUN . Karabük Üniversitesi Göz Hastalıkları Anabilim Dalı, Karabük (Bozok Tıp Derg 2017;7(1):59-63)
  • [23] Coşkun, Mehmet. “Migren Hastalıklarında Merkezi Kornea Kalınlığının Değerlendirmesi ”.www.dergipark.gov.tr.dergipark.gov.tr/article-file/292642 Access Address on March 25, 2019
  • [24] Argus VA: Ocular hypertension and central corneal thickness.Ophthalmology. 1995;102:1810- 1812.
  • [25] Ventura AC, Bohnke M, Mojon DS: “Central corneal thickness measurements in patients with normal tension glaucoma, primary open angle glaucoma, pseudoexfolia tion glaucoma, or ocular hypertension”. Br J Ophthalmol. 2001;85:792-795.
  • [26] Ko Y-C, Liu CJ-I, Hsu W-M: “Varying effects of corneal thickness on intraocular pressure measurements with different tonometers”.Eye. 2005;19:327-332
  • [27] Brandt JD, Beiser JA, Kass MA, et al.: “Central corneal thickness in the Ocular Hypertension Treatment Study (OHTS)”. Ophthalmology. 2001;108:1779-1788.
  • [28] Gordon MO, Baiser JA, Brandt JE, et al.: T”he ocular hypertension treatment study: Baseline factors that predict the onset of primary open-angle glaucoma”. Arch Ophthalmol. 2002;120: 714-720.
  • [29] Hasim, Z,. Zarina, S,. “ Osmatik Stress induced oxidative damage; Possible machansim of cataract formation in diabetes ” Journal of Diabetes and its Compilcations, 2012
There are 29 citations in total.

Details

Primary Language English
Subjects Mechanical Engineering (Other)
Journal Section Articles
Authors

Yaşar Şen 0000-0002-5292-9837

Publication Date April 29, 2024
Published in Issue Year 2024 Volume: 12 Issue: 2

Cite

APA Şen, Y. (2024). Contact Lens that Enabled Early Diagnosis for Diseases Induced by Oxidative Stress and Potassium Ion (K+) in Ocular Tissues. Düzce Üniversitesi Bilim Ve Teknoloji Dergisi, 12(2), 631-641. https://doi.org/10.29130/dubited.1352248
AMA Şen Y. Contact Lens that Enabled Early Diagnosis for Diseases Induced by Oxidative Stress and Potassium Ion (K+) in Ocular Tissues. DUBİTED. April 2024;12(2):631-641. doi:10.29130/dubited.1352248
Chicago Şen, Yaşar. “Contact Lens That Enabled Early Diagnosis for Diseases Induced by Oxidative Stress and Potassium Ion (K+) in Ocular Tissues”. Düzce Üniversitesi Bilim Ve Teknoloji Dergisi 12, no. 2 (April 2024): 631-41. https://doi.org/10.29130/dubited.1352248.
EndNote Şen Y (April 1, 2024) Contact Lens that Enabled Early Diagnosis for Diseases Induced by Oxidative Stress and Potassium Ion (K+) in Ocular Tissues. Düzce Üniversitesi Bilim ve Teknoloji Dergisi 12 2 631–641.
IEEE Y. Şen, “Contact Lens that Enabled Early Diagnosis for Diseases Induced by Oxidative Stress and Potassium Ion (K+) in Ocular Tissues”, DUBİTED, vol. 12, no. 2, pp. 631–641, 2024, doi: 10.29130/dubited.1352248.
ISNAD Şen, Yaşar. “Contact Lens That Enabled Early Diagnosis for Diseases Induced by Oxidative Stress and Potassium Ion (K+) in Ocular Tissues”. Düzce Üniversitesi Bilim ve Teknoloji Dergisi 12/2 (April 2024), 631-641. https://doi.org/10.29130/dubited.1352248.
JAMA Şen Y. Contact Lens that Enabled Early Diagnosis for Diseases Induced by Oxidative Stress and Potassium Ion (K+) in Ocular Tissues. DUBİTED. 2024;12:631–641.
MLA Şen, Yaşar. “Contact Lens That Enabled Early Diagnosis for Diseases Induced by Oxidative Stress and Potassium Ion (K+) in Ocular Tissues”. Düzce Üniversitesi Bilim Ve Teknoloji Dergisi, vol. 12, no. 2, 2024, pp. 631-4, doi:10.29130/dubited.1352248.
Vancouver Şen Y. Contact Lens that Enabled Early Diagnosis for Diseases Induced by Oxidative Stress and Potassium Ion (K+) in Ocular Tissues. DUBİTED. 2024;12(2):631-4.
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