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Antibacterial and Anti-Urease Activities of Chloropheniramine maleat, Paracetamol and Clarithromycine

Year 2019, Volume: 7 Issue: 1, 194 - 200, 31.01.2019
https://doi.org/10.29130/dubited.432506

Abstract

This paper presents anti-urease and antibacterial activities of chloropheniramine maleat, paracetamol and
clarithromycine. Antibacterial activity of the compounds was investigated against Salmonella enterica,
Enterobacter aerogenes, Bacillus subtilis, Proteus vulgaris, Gordonia rubripertincta, Klebsiella pneumoniae and
Enterococcus faecalis. Moreover, anti-urease activity of the compounds was searched. All tested compounds
demonstrated antibacterial action with varying degree except for chloropheniramine maleat. Chloropheniramine
maleat, paracetamol and chlarithromycine exhibited higher activity than thiourea. The data obtained from the
study, chloropheniramine maleate, paracetamol and clarithromycin are thought to be useful as new urease
inhibitors and the present study should be supported by further studies. Furthermore, it is thought that paracetamol
has antibacterial properties and therefore can be used as an alternative to antibiotics

References

  • [1] R. Dabur, A. Gupta, T. K. Mandal, D. D. Singh, V. Bajpai, A. M. Guray and G. S. Lavekar, “Antimicrobial activity of some Indian medicinal plants,” African Journal of Traditional, Complementary and Alternative Medicine, vol. 4, no. 3, pp. 313-318, 2007.
  • [2] R. C. Moellering, “Discovering new antimicrobial agents,” International Journal of Antimicrobial Agents, vol. 37, no. 1, pp. 2-9, 2011.
  • [3] S. Mahernia, K. Bagherzadeh, F. Molab and M. Amaniou, “Urease inhibitory activities of some commonly consumed herbal medicines,” Iran Journal of Pharmaceutical Research, vol. 14, no. 3, pp. 943-947, 2015.
  • [4] B. B. Sökmen, H. Ç. Onar, A. Yusufoğlu and R. Yanardağ, “Anti-elastase, anti-urease and antioxidant activities of (3–13)-monohydroxyeicosanoic acid isomers,” Journal of The Serbian Chemical Society, vol. 77, no. 10, pp. 1353-1361, 2012.
  • [5] G. P. Chan, B. Y. Garcia-Ignacio, V. E. Chavez, J. B. Livelo, C. L. Jimenez, M. L. R. Parrilla and S. G. Franzblau, “Clinical trial of clarithromycin for lepromatous leprosy,” Antimicrobial Agents and Chemotheraphy, vol. 38, no 3, pp. 515-517, 1994.
  • [6] M. Lebel, “Pharmacokinetic properties of clarithromycin: a comparison with erythromycin and azithromycin,” Canadian Journal of Infectious Disease and Medicine, vol. 4, no. 3, pp. 148-152, 1993.
  • [7] T. A. Saleh, “Sensing of chloropheniramine in Pharmaceutical applications by sequential injector coupled with potentiometer,” International Journal of Pharmaceuticals Analysis, vol. 1, no. 4, pp. 246-250, 2011.
  • [8] A. Wilcock and R. Twycross, “Therapeutic reviews,” Journal of Pain and Symptom Management, vol. 46, no. 5, pp. 747-755, 2013.
  • [9] M. Güllüce, A. Adıgüzel, H. Öğütçü, M. Şengül, I. Karaman and F. Şahin, “Antimicrobial effects of Quercus ilex L. extract,” Phytotheraphy Research, vol. 18, pp. 208-211, 2004.
  • [10] D. D. E Van Slyke and R. M. Archibald, “Manometric, titrimetric and colorimetric methods for measurement of urease activity,” The Journal of Biological Chemistry, vol. 154, pp. 623-642, 1944.
  • [11] A. A. Mostafa, A. A., Al-Askar K. S. Almaary, T. M. Dawoud, E. N. Sholkamy and M. M. Bakri, “Antimicrobial activity of some plant extracts against bacterial strains causing food poisoning diseases,” Saudi Journal of Biological Sciences, vol. 25, no. 2, pp. 361-366, 2018.
  • [12] D. E. Djeussi, J. A. K. Noumedem, J. A. Seukep, A. G. Fankam, I. K. Voukeng, S. B. Tankeo, A. H. L. Nkuete and V. Kuete, “Antibacterial activities of selected edible plant extracts against multi-drg resistant Gram-negative bacteria,” BMC Complementary and Alternative Medicine, vol. 13, pp. 164-172, 2013.
  • [13] P. Zimmermann and N. Curtis, “Antimicrobial effects of antipyretics,” Antimicrobial Agents and Chemotheraphy, vol. 61, no. 4, pp. 1-12, 2017.
  • [14] A. A. Hussein and S. Al-Janabi, “In vitro antibacterial activity of ibuprofen and acetaminophen,” Journal of Global Infectious Disease, vol. 2, no. 2, pp. 105-108, 2010.
  • [15] A. Ferrera, C. D. Santos, M. Cimbro and G. G. Grassi, “Comparative antimicrobial activity and post- antibiotic effect of azithromycine, clarithromycine and roxithromycin against some respiratory pathogens,” International Journal of Antimicrobial Agents, vol. 7, pp. 181-186, 1996.
  • [16] K. L. Bergman, K. M. Olsen, T. E. Peddicord, P. D. Fey and M. E. Rupp, “Antimicrobial activities and postantibiotic effects of clarithromycin, 14-hydroxy-clarithromycin, and azithromycin in epithelial cell lining fluid against clinical isolates of Haemophilus influenzae and Streptococcus pneumoniae,” Antimicrobial Agents and Chemotheraphy, vol. 43, no. 5, pp. 1291-1293, 1999.
  • [17] S. T. S. Hassan, E. Svajdlenka and K. Berchova-Bimova, “Hibiscus sabdariffa L. and its bioactive constituents exhibit antiviral activity against HSV-2 and anti-enzymatic properties against urease by an ESI-MS based assay,” Molecules, vol. 22, no. 5, pp. 702-734, 2017.

Klorofeniramin Maleat, Parasetamol ve Klaritromisin’in Antibakteriyal ve Anti-Ureaz Aktiviteleri

Year 2019, Volume: 7 Issue: 1, 194 - 200, 31.01.2019
https://doi.org/10.29130/dubited.432506

Abstract

Bu çalışmada klorofeniramin maleat, parasetamol ve klaritromisin’in antibakteriyal ve anti-üreaz aktiviteleri ile
ilgilenmektedir. Maddelerin antibakteriyal aktiviteleri Salmonella enterica, Enterobacter aerogenes, Bacillus
subtilis, Proteus vulgaris, Gordonia rubripertincta, Klebsiella pneumoniae, Bacillus megaterium ve Enterococcus
faecalis’e karşı araştırıldı. Bu maddelerin anti-üreaz aktiviteleri de incelendi. Klorofeniramin maleat dışında, test
edilen tüm bileşikler değişik oranlarda antibakteriyal etki gösterdi. Klorofeniramin maleat, parasetamol ve
klaritromisin tiyoüreden daha yüksek aktivite gösterdi. Çalışmadan elde edilen veriler, klorofeniramin maleat,
parasetamol ve klaritromisin yeni üreaz inhibitörü olarak kullanılabileceğini düşünülmüş olup mevcut çalışma
daha ileri çalışmalar ile de desteklenmelidir. Ayrıca, parasetamolün antibakteriyel özelliklere sahip olduğu ve bu
nedenle antibiyotiklere alternatif olarak kullanılabileceği düşünülmektedir.

References

  • [1] R. Dabur, A. Gupta, T. K. Mandal, D. D. Singh, V. Bajpai, A. M. Guray and G. S. Lavekar, “Antimicrobial activity of some Indian medicinal plants,” African Journal of Traditional, Complementary and Alternative Medicine, vol. 4, no. 3, pp. 313-318, 2007.
  • [2] R. C. Moellering, “Discovering new antimicrobial agents,” International Journal of Antimicrobial Agents, vol. 37, no. 1, pp. 2-9, 2011.
  • [3] S. Mahernia, K. Bagherzadeh, F. Molab and M. Amaniou, “Urease inhibitory activities of some commonly consumed herbal medicines,” Iran Journal of Pharmaceutical Research, vol. 14, no. 3, pp. 943-947, 2015.
  • [4] B. B. Sökmen, H. Ç. Onar, A. Yusufoğlu and R. Yanardağ, “Anti-elastase, anti-urease and antioxidant activities of (3–13)-monohydroxyeicosanoic acid isomers,” Journal of The Serbian Chemical Society, vol. 77, no. 10, pp. 1353-1361, 2012.
  • [5] G. P. Chan, B. Y. Garcia-Ignacio, V. E. Chavez, J. B. Livelo, C. L. Jimenez, M. L. R. Parrilla and S. G. Franzblau, “Clinical trial of clarithromycin for lepromatous leprosy,” Antimicrobial Agents and Chemotheraphy, vol. 38, no 3, pp. 515-517, 1994.
  • [6] M. Lebel, “Pharmacokinetic properties of clarithromycin: a comparison with erythromycin and azithromycin,” Canadian Journal of Infectious Disease and Medicine, vol. 4, no. 3, pp. 148-152, 1993.
  • [7] T. A. Saleh, “Sensing of chloropheniramine in Pharmaceutical applications by sequential injector coupled with potentiometer,” International Journal of Pharmaceuticals Analysis, vol. 1, no. 4, pp. 246-250, 2011.
  • [8] A. Wilcock and R. Twycross, “Therapeutic reviews,” Journal of Pain and Symptom Management, vol. 46, no. 5, pp. 747-755, 2013.
  • [9] M. Güllüce, A. Adıgüzel, H. Öğütçü, M. Şengül, I. Karaman and F. Şahin, “Antimicrobial effects of Quercus ilex L. extract,” Phytotheraphy Research, vol. 18, pp. 208-211, 2004.
  • [10] D. D. E Van Slyke and R. M. Archibald, “Manometric, titrimetric and colorimetric methods for measurement of urease activity,” The Journal of Biological Chemistry, vol. 154, pp. 623-642, 1944.
  • [11] A. A. Mostafa, A. A., Al-Askar K. S. Almaary, T. M. Dawoud, E. N. Sholkamy and M. M. Bakri, “Antimicrobial activity of some plant extracts against bacterial strains causing food poisoning diseases,” Saudi Journal of Biological Sciences, vol. 25, no. 2, pp. 361-366, 2018.
  • [12] D. E. Djeussi, J. A. K. Noumedem, J. A. Seukep, A. G. Fankam, I. K. Voukeng, S. B. Tankeo, A. H. L. Nkuete and V. Kuete, “Antibacterial activities of selected edible plant extracts against multi-drg resistant Gram-negative bacteria,” BMC Complementary and Alternative Medicine, vol. 13, pp. 164-172, 2013.
  • [13] P. Zimmermann and N. Curtis, “Antimicrobial effects of antipyretics,” Antimicrobial Agents and Chemotheraphy, vol. 61, no. 4, pp. 1-12, 2017.
  • [14] A. A. Hussein and S. Al-Janabi, “In vitro antibacterial activity of ibuprofen and acetaminophen,” Journal of Global Infectious Disease, vol. 2, no. 2, pp. 105-108, 2010.
  • [15] A. Ferrera, C. D. Santos, M. Cimbro and G. G. Grassi, “Comparative antimicrobial activity and post- antibiotic effect of azithromycine, clarithromycine and roxithromycin against some respiratory pathogens,” International Journal of Antimicrobial Agents, vol. 7, pp. 181-186, 1996.
  • [16] K. L. Bergman, K. M. Olsen, T. E. Peddicord, P. D. Fey and M. E. Rupp, “Antimicrobial activities and postantibiotic effects of clarithromycin, 14-hydroxy-clarithromycin, and azithromycin in epithelial cell lining fluid against clinical isolates of Haemophilus influenzae and Streptococcus pneumoniae,” Antimicrobial Agents and Chemotheraphy, vol. 43, no. 5, pp. 1291-1293, 1999.
  • [17] S. T. S. Hassan, E. Svajdlenka and K. Berchova-Bimova, “Hibiscus sabdariffa L. and its bioactive constituents exhibit antiviral activity against HSV-2 and anti-enzymatic properties against urease by an ESI-MS based assay,” Molecules, vol. 22, no. 5, pp. 702-734, 2017.
There are 17 citations in total.

Details

Primary Language English
Subjects Engineering
Journal Section Articles
Authors

Sinem Aydın

Publication Date January 31, 2019
Published in Issue Year 2019 Volume: 7 Issue: 1

Cite

APA Aydın, S. (2019). Antibacterial and Anti-Urease Activities of Chloropheniramine maleat, Paracetamol and Clarithromycine. Düzce Üniversitesi Bilim Ve Teknoloji Dergisi, 7(1), 194-200. https://doi.org/10.29130/dubited.432506
AMA Aydın S. Antibacterial and Anti-Urease Activities of Chloropheniramine maleat, Paracetamol and Clarithromycine. DUBİTED. January 2019;7(1):194-200. doi:10.29130/dubited.432506
Chicago Aydın, Sinem. “Antibacterial and Anti-Urease Activities of Chloropheniramine Maleat, Paracetamol and Clarithromycine”. Düzce Üniversitesi Bilim Ve Teknoloji Dergisi 7, no. 1 (January 2019): 194-200. https://doi.org/10.29130/dubited.432506.
EndNote Aydın S (January 1, 2019) Antibacterial and Anti-Urease Activities of Chloropheniramine maleat, Paracetamol and Clarithromycine. Düzce Üniversitesi Bilim ve Teknoloji Dergisi 7 1 194–200.
IEEE S. Aydın, “Antibacterial and Anti-Urease Activities of Chloropheniramine maleat, Paracetamol and Clarithromycine”, DUBİTED, vol. 7, no. 1, pp. 194–200, 2019, doi: 10.29130/dubited.432506.
ISNAD Aydın, Sinem. “Antibacterial and Anti-Urease Activities of Chloropheniramine Maleat, Paracetamol and Clarithromycine”. Düzce Üniversitesi Bilim ve Teknoloji Dergisi 7/1 (January 2019), 194-200. https://doi.org/10.29130/dubited.432506.
JAMA Aydın S. Antibacterial and Anti-Urease Activities of Chloropheniramine maleat, Paracetamol and Clarithromycine. DUBİTED. 2019;7:194–200.
MLA Aydın, Sinem. “Antibacterial and Anti-Urease Activities of Chloropheniramine Maleat, Paracetamol and Clarithromycine”. Düzce Üniversitesi Bilim Ve Teknoloji Dergisi, vol. 7, no. 1, 2019, pp. 194-00, doi:10.29130/dubited.432506.
Vancouver Aydın S. Antibacterial and Anti-Urease Activities of Chloropheniramine maleat, Paracetamol and Clarithromycine. DUBİTED. 2019;7(1):194-200.