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İlaç Formülasyonundaki Asetilsalisilik Asit, Parasetamol ve Kafeinin Kemometrik Metotlarla Tayini

Year 2019, Volume: 21 Issue: 61, 185 - 194, 15.01.2019

Güzide Pekcan Ertokuş Ayşe Merve Akkaya Ziya Mermertaş Reciye Kurşunlu

Abstract

Bu çalışmada,  tablet ilaç numunesinde bulunan parasetamol,
asetilsalisilik asit ve kafein etken maddelerinin ultraviyole
spektrofotometrisi yöntemi ile elde edilen sonuçlarının kemometrik metotlarla
birlikte değerlendirilmesi ile tayini gerçekleştirilmiştir. Deneysel çalışmada
maddelerin tek tek saf haldeki spektrumları elde edildikten sonra her bir ilaç
etken maddesinden alınarak sentetik karışım hazırlanmıştır. Bir sonraki aşamada
tablet numunesi analizi yapılmıştır. Kemometrik yöntemlerden, temel bileşen
regresyonu yöntemi (PCR) ve kısmi en küçük kareler yöntemi (PLS), sentetik
karışım ve tablet numunesindeki miktar tayininde başarı ile uygulanmıştır. Elde
edilen veriler, istatistik olarak incelendiklerinde hem hesaplanan geri kazanım
değerleri yüksek hem de standart sapmalar yeterince küçüktür. Ayrıca yöntemin
uygunluğu açısından F-testi uygulanmış ve sonuçlar uyumlu bulunmuştur.
Uygulanan kemometrik yöntemler yardımıyla elde edilen sonuçlar son derece
hızlı, basit ve güvenilir sonuçlardır.

Keywords

Asetilsalisilik asit Parasetamol Kafein Kemometri

References

  • [1] Issa, Y.M., Zayed, S.I.M., Habib, I.H.I. 2011. Simultaneous determination of ibuprofen and paracetamol using derivatives of the ratio spectra method, Arabian Journal Of Chemistry, 4(3), s. 259-263.
  • [2] Khoshayand, M.R., Abdollahi, H., Shariatpanahi, M., Saadatfard, A., Mohammadi, A. 2008. Simultaneous spectrophotometric determination of paracetamol, ibuprofen and caffeine in pharmaceuticals by chemometric methods, Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy,70(3), s. 491-499,
  • [3] Dinç, E. 2003. Linear regression analysis and its application to the multivariate spectral calibrations fort he multiresolution of a ternary mixture of caffeine, paracetamol and metamizol in tablets, Journal of pharmaceutical and biomedical analysis, 33, s. 605-615.
  • [4] Glavanovic, S., Glavanovic, M., Tomisic V. 2016. Simultaneous quantitative determination of paracetamol and tramadol in tablet formulation using UV spectrophotometry and chemometric methods, Spectrochimica Acta PartA:Molecular and Biomolecular Spectroscopy,157, s. 258-264.
  • [5] Hajian R., Afshari N. 2012. The spectrophotometric multicomponent analysis of a ternary mixture of ibuprofen, caffeine and paracetamol bu the combination of double divisor-ratio spectra derivative and H-point standard addition method, E-journal of chemistry, 9(3), s. 1153-1164.
  • [6] Saraan S.M.D., Sinaga S.M., Muchlisyam 2015. Development method for the determination of ternary mixture of paracetamol, ibuprofen and caffeine in tablet dosage form using zero-crossing derivative spectrophotometric, International journal of pharmtach research, 7(2), 349-353, s. 2014-2015.
  • [7] Wedian F. 2016. Bivariate analysis for the determination of paracetamol and caffeine in drug formulations, Jordan journal of chemistry, 11(4), s. 217-225.
  • [8] Muntean D.M., Alecu C., Tomuta I. 2017. Simultaneous quantification of paracetamol and caffeine in powder blends for tableting by NIR-Chemometry, Journal of spectroscopy, s. 1-8.
  • [9] Prado T.M., Cincotto F.H., Machado S.A.S. 2017. Spectroelectrochemical study of acetylsalicylic acid in neutral medium and its quantification in clinical and environmental samples, Electrochimica Acta,233, s. 105-112.
  • [10] Shervani Z., Ikushima Y. 2001. Hydrolysis of acetylsalicylic acid in AOT/near-critical propane microemılsion:A model hydrolysis reaction in high pressure microemulsion as investigated by in situ UV-vis spectroscopy, The American Chemical Society, 222, U332.
  • [11] Neuberger S., Jooss K., Flottmann D. 2017. Raman spectroscopy and capillary zone electrophoresis for the analysis of degradation processes in commercial effervescent tablets containing acetylsalicylic acid and ascorbic acid, Journal of pharmaceutical and biomedical analysis, 134, s. 122-129.
  • [12] Panahi H.A., Rahimi A., Moniri E., Izadi A., Parvin M.M. 2010. HPTLC separation and quantitative analysis of aspirin, salicylic acid and sulfosalicyclic acid, Journal of planar chromatography-modern TLC, 23(2), s. 137-140.
  • [13] Novikova A., Carstensen J.M., Rades T., Leopold C.S. 2017. UV imaging of multiple unit pellet system (MUPS) tablets: a case study of acetylsalicylic acid stability, European journal of pharmaceutics and biopharmaceutics, 119, s. 447-453.
  • [14] Souri E., Nasab S.A.M., Amanlou M., Tehrani M.B. 2015. Development and validation of a rapid derivative spectrophotometric method for simultaneous determination of acetaminophen, ibuprofen and caffeine, Journal of analytical chemistry, 70(3), s. 333-338.
  • [15] Aktaş A.H., Pekcan H. 2013. Chemometric methods for the simultaneous spectrophotometric determination of caffeine, theobromine and theophylline in tea, Asian journal of chemistry, 25(15), s. 8333-8338.
  • [16] Dinç E., Baleanu D., Onur F. 2001. Spectrophotometric multicomponent analysis of a mixture of metamizol, acetaminophen and caffeine in pharmaceutical formulations by two chemometric tchniques, Journal of pharmaceutical and biomedical analysis, 26, s. 949-957.
  • [17] Pereira V.P., Knor F.J., Vellosa J.C.R., Beltrame F.L. 2014. Determination of phenolic compounds and antioxidant activity of green, black and white teas of Camellia sinensis (L.) Kuntze, Theaceae, Campinas, 16(3), s. 490-498.
  • [18] Srdjenovic B., Djordjevic-Milic V., Grujic N., Injac R., Lepojevic Z. 2008. Journal of chromatographic science, 46, s. 144-149.
  • [19] Shehata A.B., Rizk M.S., Rend E.A. 2016, Journal of food and drug analysis, 24, s. 703-715.
  • [20] Frizzarin R.M., Maya F., Estela J.M., Cerda V. 2016. Fully-automated in-syringe dispersive liquid-liquid microextraction for the determination of caffeine in coffee beverages, Food chemistry, 212, s. 759-767.
  • [21] Dinç E., Baleanu D. 2002. Spectrophotometric quantitative determination of cilazapril and hydrochlorothiazide in tablets by chemometric methods, Journal of pharmaceutical and biomedical analysis, 30, s. 715-723.
  • [22] Dinç E.,Özdemir A., Baleanu D. 2005. Comparative study of the continuous wavelet transform, derivative and partial least squares methods applied to the overlapping spectra for the simultaneous quantitative resolution of ascorbic acid and acetylsalicylic acid in effervescent tablets, Journal of pharmaceutical and biomedical analysis, 37(3), s. 569-575.
  • [23] Uyanık A. 2008. Analitik Kimyacılar için İstatistik ve Kemometri, 5. Baskı, s. 254-259.
  • [24] Dinç,E. 2009. Kemometrik İşlem ve Yöntemlerin Analitik Kimyadaki Tipik Uygulamaları, Kemometri Yaz Okulu Notları, s. 13-17.
  • [25] Kaba, A., Aktaş A.H. 2014. Çeşitli Ligandları Kullanarak Fe3+, Al3+ ve Cu2+ nin Bir Arada Spektrofotometrik Tayinleri İçin Yöntem Geliştirilmesi ve Elde Edilen Verilerin En Küçük Kareler Kalibrasyon Yöntemi (PLS) ve Temel Bileşen Regresyon (PCR) Yöntemi ile Değerlendirilmesi, SAUFBE, Cilt 18, Sayı 1, s. 71-79.
  • [26] Aktaş AH, Mutlutürk B. 2014. Demir ve Alüminyumun Doğal Sularda UV Spektrofotometrik Tayini için Yöntem Geliştirilmesi ve Elde Edilen Verilerin Kemometrik Kalibrasyon Yöntemleriyle Değerlendirilmesi, Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, vol. 18(3), s.52-59.
  • [27]Minitab 17 Statistical Programme: http://www.inovadanismanlik.com.tr (30.11.2017)
  • [28] Ershov, B.G., Panich, N.M. 2018. Chemical and Spectral Behavior of Nitric Acid in Aqueous Sulfuric Acid Solutions: Absorption Spectrum and Molar Absorption Coefficient of Nitronium Ion, Spectrochimica Acta Part A, Molecular And Biomolecular Spectroscopy, vol.188, s. 179-182.
  • [29] Eissler, S., Kley, M., Bachle, D., Loidl, G., Meier, T., Samson, D. 2017. Substitution Determination of Fmoc-Substituted Resins at Different Wavelengths, Journal of Peptide Science, vol.23, s. 757-762.
  • [30] Miao, J., Forget, B., Smith, K. 2018. Predicting Correlation Coefficients for Monte Carlo Eigenvalue Simulations With Multitype Branching Process, Annals of Nuclear Energy, vol.112, s. 307-321.
  • [31] Saganowska, P., Wesolowski, M. 2017. Principal Component and Cluster Analyses as Supporting Tools for Co-Crystals Detection”, J.Therm.Anal.Calorim., vol.130, s. 45-55.
  • [32] Porfire, A., Muntean, D., Achim, M., Vlase, L., Tomuta, I. 2015. Simultaneous Quantification of Simvastatin and Excipients in Liposomes Using Near Spectroscopy and Chemometry, Journal of Pharmaceutical and Biomedical Analysis, vol.107, s. 40-49.
  • [33] Tarhan, I., Kara, A.A.I.H. 2017. Quantitative Determination of Free Fatty Acids in Extra Virgin Olive Oils by Multivariate Methods and Fourier Transform Infrared Spectroscopy Considering Different Absorption Modes, International Journal of Food Properties, s. 1-8.

Determination of Acetylsalicylic Acid, Paracetamol and Caffeine in Drug Formulation with Chemometric Methods

Year 2019, Volume: 21 Issue: 61, 185 - 194, 15.01.2019

Güzide Pekcan Ertokuş Ayşe Merve Akkaya Ziya Mermertaş Reciye Kurşunlu

Abstract

In this study, the results of
ultraviolet spectrophotometry of paracetamol, acetylsalicylic acid and caffeine
active substances in tablet drug sample were evaluated together with
chemometric methods. In the experimental study, the synthetic mixtures were
prepared by taking each drug from the active ingredient after obtaining the
individual pure spectra of the substances. At the next stage, a tablet sample
analysis was performed. From the chemometric methods, the principle component
regression method (PCR) and the partial least squares method (PLS) have been
successfully applied in the quantification of the synthetic mixtures and the
tablet sample. When the data obtained are statistically analyzed, both the
calculated recovery values ​​are high and the standard deviations are small
enough. In addition, F-test was applied in terms of the suitability of the
method and the results were found to be compatible. The results obtained with
the help of applied chemometric methods are very fast, simple and reliable
results.

Keywords

Acetylsalicylic acid Paracetamol Cafffeine Chemometry

References

  • [1] Issa, Y.M., Zayed, S.I.M., Habib, I.H.I. 2011. Simultaneous determination of ibuprofen and paracetamol using derivatives of the ratio spectra method, Arabian Journal Of Chemistry, 4(3), s. 259-263.
  • [2] Khoshayand, M.R., Abdollahi, H., Shariatpanahi, M., Saadatfard, A., Mohammadi, A. 2008. Simultaneous spectrophotometric determination of paracetamol, ibuprofen and caffeine in pharmaceuticals by chemometric methods, Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy,70(3), s. 491-499,
  • [3] Dinç, E. 2003. Linear regression analysis and its application to the multivariate spectral calibrations fort he multiresolution of a ternary mixture of caffeine, paracetamol and metamizol in tablets, Journal of pharmaceutical and biomedical analysis, 33, s. 605-615.
  • [4] Glavanovic, S., Glavanovic, M., Tomisic V. 2016. Simultaneous quantitative determination of paracetamol and tramadol in tablet formulation using UV spectrophotometry and chemometric methods, Spectrochimica Acta PartA:Molecular and Biomolecular Spectroscopy,157, s. 258-264.
  • [5] Hajian R., Afshari N. 2012. The spectrophotometric multicomponent analysis of a ternary mixture of ibuprofen, caffeine and paracetamol bu the combination of double divisor-ratio spectra derivative and H-point standard addition method, E-journal of chemistry, 9(3), s. 1153-1164.
  • [6] Saraan S.M.D., Sinaga S.M., Muchlisyam 2015. Development method for the determination of ternary mixture of paracetamol, ibuprofen and caffeine in tablet dosage form using zero-crossing derivative spectrophotometric, International journal of pharmtach research, 7(2), 349-353, s. 2014-2015.
  • [7] Wedian F. 2016. Bivariate analysis for the determination of paracetamol and caffeine in drug formulations, Jordan journal of chemistry, 11(4), s. 217-225.
  • [8] Muntean D.M., Alecu C., Tomuta I. 2017. Simultaneous quantification of paracetamol and caffeine in powder blends for tableting by NIR-Chemometry, Journal of spectroscopy, s. 1-8.
  • [9] Prado T.M., Cincotto F.H., Machado S.A.S. 2017. Spectroelectrochemical study of acetylsalicylic acid in neutral medium and its quantification in clinical and environmental samples, Electrochimica Acta,233, s. 105-112.
  • [10] Shervani Z., Ikushima Y. 2001. Hydrolysis of acetylsalicylic acid in AOT/near-critical propane microemılsion:A model hydrolysis reaction in high pressure microemulsion as investigated by in situ UV-vis spectroscopy, The American Chemical Society, 222, U332.
  • [11] Neuberger S., Jooss K., Flottmann D. 2017. Raman spectroscopy and capillary zone electrophoresis for the analysis of degradation processes in commercial effervescent tablets containing acetylsalicylic acid and ascorbic acid, Journal of pharmaceutical and biomedical analysis, 134, s. 122-129.
  • [12] Panahi H.A., Rahimi A., Moniri E., Izadi A., Parvin M.M. 2010. HPTLC separation and quantitative analysis of aspirin, salicylic acid and sulfosalicyclic acid, Journal of planar chromatography-modern TLC, 23(2), s. 137-140.
  • [13] Novikova A., Carstensen J.M., Rades T., Leopold C.S. 2017. UV imaging of multiple unit pellet system (MUPS) tablets: a case study of acetylsalicylic acid stability, European journal of pharmaceutics and biopharmaceutics, 119, s. 447-453.
  • [14] Souri E., Nasab S.A.M., Amanlou M., Tehrani M.B. 2015. Development and validation of a rapid derivative spectrophotometric method for simultaneous determination of acetaminophen, ibuprofen and caffeine, Journal of analytical chemistry, 70(3), s. 333-338.
  • [15] Aktaş A.H., Pekcan H. 2013. Chemometric methods for the simultaneous spectrophotometric determination of caffeine, theobromine and theophylline in tea, Asian journal of chemistry, 25(15), s. 8333-8338.
  • [16] Dinç E., Baleanu D., Onur F. 2001. Spectrophotometric multicomponent analysis of a mixture of metamizol, acetaminophen and caffeine in pharmaceutical formulations by two chemometric tchniques, Journal of pharmaceutical and biomedical analysis, 26, s. 949-957.
  • [17] Pereira V.P., Knor F.J., Vellosa J.C.R., Beltrame F.L. 2014. Determination of phenolic compounds and antioxidant activity of green, black and white teas of Camellia sinensis (L.) Kuntze, Theaceae, Campinas, 16(3), s. 490-498.
  • [18] Srdjenovic B., Djordjevic-Milic V., Grujic N., Injac R., Lepojevic Z. 2008. Journal of chromatographic science, 46, s. 144-149.
  • [19] Shehata A.B., Rizk M.S., Rend E.A. 2016, Journal of food and drug analysis, 24, s. 703-715.
  • [20] Frizzarin R.M., Maya F., Estela J.M., Cerda V. 2016. Fully-automated in-syringe dispersive liquid-liquid microextraction for the determination of caffeine in coffee beverages, Food chemistry, 212, s. 759-767.
  • [21] Dinç E., Baleanu D. 2002. Spectrophotometric quantitative determination of cilazapril and hydrochlorothiazide in tablets by chemometric methods, Journal of pharmaceutical and biomedical analysis, 30, s. 715-723.
  • [22] Dinç E.,Özdemir A., Baleanu D. 2005. Comparative study of the continuous wavelet transform, derivative and partial least squares methods applied to the overlapping spectra for the simultaneous quantitative resolution of ascorbic acid and acetylsalicylic acid in effervescent tablets, Journal of pharmaceutical and biomedical analysis, 37(3), s. 569-575.
  • [23] Uyanık A. 2008. Analitik Kimyacılar için İstatistik ve Kemometri, 5. Baskı, s. 254-259.
  • [24] Dinç,E. 2009. Kemometrik İşlem ve Yöntemlerin Analitik Kimyadaki Tipik Uygulamaları, Kemometri Yaz Okulu Notları, s. 13-17.
  • [25] Kaba, A., Aktaş A.H. 2014. Çeşitli Ligandları Kullanarak Fe3+, Al3+ ve Cu2+ nin Bir Arada Spektrofotometrik Tayinleri İçin Yöntem Geliştirilmesi ve Elde Edilen Verilerin En Küçük Kareler Kalibrasyon Yöntemi (PLS) ve Temel Bileşen Regresyon (PCR) Yöntemi ile Değerlendirilmesi, SAUFBE, Cilt 18, Sayı 1, s. 71-79.
  • [26] Aktaş AH, Mutlutürk B. 2014. Demir ve Alüminyumun Doğal Sularda UV Spektrofotometrik Tayini için Yöntem Geliştirilmesi ve Elde Edilen Verilerin Kemometrik Kalibrasyon Yöntemleriyle Değerlendirilmesi, Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, vol. 18(3), s.52-59.
  • [27]Minitab 17 Statistical Programme: http://www.inovadanismanlik.com.tr (30.11.2017)
  • [28] Ershov, B.G., Panich, N.M. 2018. Chemical and Spectral Behavior of Nitric Acid in Aqueous Sulfuric Acid Solutions: Absorption Spectrum and Molar Absorption Coefficient of Nitronium Ion, Spectrochimica Acta Part A, Molecular And Biomolecular Spectroscopy, vol.188, s. 179-182.
  • [29] Eissler, S., Kley, M., Bachle, D., Loidl, G., Meier, T., Samson, D. 2017. Substitution Determination of Fmoc-Substituted Resins at Different Wavelengths, Journal of Peptide Science, vol.23, s. 757-762.
  • [30] Miao, J., Forget, B., Smith, K. 2018. Predicting Correlation Coefficients for Monte Carlo Eigenvalue Simulations With Multitype Branching Process, Annals of Nuclear Energy, vol.112, s. 307-321.
  • [31] Saganowska, P., Wesolowski, M. 2017. Principal Component and Cluster Analyses as Supporting Tools for Co-Crystals Detection”, J.Therm.Anal.Calorim., vol.130, s. 45-55.
  • [32] Porfire, A., Muntean, D., Achim, M., Vlase, L., Tomuta, I. 2015. Simultaneous Quantification of Simvastatin and Excipients in Liposomes Using Near Spectroscopy and Chemometry, Journal of Pharmaceutical and Biomedical Analysis, vol.107, s. 40-49.
  • [33] Tarhan, I., Kara, A.A.I.H. 2017. Quantitative Determination of Free Fatty Acids in Extra Virgin Olive Oils by Multivariate Methods and Fourier Transform Infrared Spectroscopy Considering Different Absorption Modes, International Journal of Food Properties, s. 1-8.
There are 33 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Güzide Pekcan Ertokuş 0000-0001-9230-5634

Ayşe Merve Akkaya This is me

Ziya Mermertaş This is me

Reciye Kurşunlu This is me

Publication Date January 15, 2019
Published in Issue Year 2019 Volume: 21 Issue: 61

Cite

APA Pekcan Ertokuş, G., Akkaya, A. M., Mermertaş, Z., Kurşunlu, R. (2019). İlaç Formülasyonundaki Asetilsalisilik Asit, Parasetamol ve Kafeinin Kemometrik Metotlarla Tayini. Dokuz Eylül Üniversitesi Mühendislik Fakültesi Fen Ve Mühendislik Dergisi, 21(61), 185-194.
AMA Pekcan Ertokuş G, Akkaya AM, Mermertaş Z, Kurşunlu R. İlaç Formülasyonundaki Asetilsalisilik Asit, Parasetamol ve Kafeinin Kemometrik Metotlarla Tayini. DEUFMD. January 2019;21(61):185-194.
Chicago Pekcan Ertokuş, Güzide, Ayşe Merve Akkaya, Ziya Mermertaş, and Reciye Kurşunlu. “İlaç Formülasyonundaki Asetilsalisilik Asit, Parasetamol Ve Kafeinin Kemometrik Metotlarla Tayini”. Dokuz Eylül Üniversitesi Mühendislik Fakültesi Fen Ve Mühendislik Dergisi 21, no. 61 (January 2019): 185-94.
EndNote Pekcan Ertokuş G, Akkaya AM, Mermertaş Z, Kurşunlu R (January 1, 2019) İlaç Formülasyonundaki Asetilsalisilik Asit, Parasetamol ve Kafeinin Kemometrik Metotlarla Tayini. Dokuz Eylül Üniversitesi Mühendislik Fakültesi Fen ve Mühendislik Dergisi 21 61 185–194.
IEEE G. Pekcan Ertokuş, A. M. Akkaya, Z. Mermertaş, and R. Kurşunlu, “İlaç Formülasyonundaki Asetilsalisilik Asit, Parasetamol ve Kafeinin Kemometrik Metotlarla Tayini”, DEUFMD, vol. 21, no. 61, pp. 185–194, 2019.
ISNAD Pekcan Ertokuş, Güzide et al. “İlaç Formülasyonundaki Asetilsalisilik Asit, Parasetamol Ve Kafeinin Kemometrik Metotlarla Tayini”. Dokuz Eylül Üniversitesi Mühendislik Fakültesi Fen ve Mühendislik Dergisi 21/61 (January 2019), 185-194.
JAMA Pekcan Ertokuş G, Akkaya AM, Mermertaş Z, Kurşunlu R. İlaç Formülasyonundaki Asetilsalisilik Asit, Parasetamol ve Kafeinin Kemometrik Metotlarla Tayini. DEUFMD. 2019;21:185–194.
MLA Pekcan Ertokuş, Güzide et al. “İlaç Formülasyonundaki Asetilsalisilik Asit, Parasetamol Ve Kafeinin Kemometrik Metotlarla Tayini”. Dokuz Eylül Üniversitesi Mühendislik Fakültesi Fen Ve Mühendislik Dergisi, vol. 21, no. 61, 2019, pp. 185-94.
Vancouver Pekcan Ertokuş G, Akkaya AM, Mermertaş Z, Kurşunlu R. İlaç Formülasyonundaki Asetilsalisilik Asit, Parasetamol ve Kafeinin Kemometrik Metotlarla Tayini. DEUFMD. 2019;21(61):185-94.

Dokuz Eylül Üniversitesi, Mühendislik Fakültesi Dekanlığı Tınaztepe Yerleşkesi, Adatepe Mah. Doğuş Cad. No: 207-I / 35390 Buca-İZMİR.