Research Article
Comparison of Proton and Photon Radiotheraphy for Left-sided Breast Cancer via Dosimetric Calculations
Abstract
Breast cancer is the most common type of cancer in women. Today, the radiotherapy method is widely preferred to treat cancer patients where proton therapy is a radiotherapy method used to destroy cancerous cells using proton beams with unique characteristics. Photon therapy, on the other hand, is a classical radiotherapy method that treats cancerous cells by targeting ionizing radiation. In our study, a tumor was placed in the left breast in a water phantom with the help of the Geant4 simulation program and geometry with critical organs was modeled. With this simulation, the doses received by the organs were interpreted and comparisons were made using the chi-square method as the two different source beams, proton and photon deployed. When the percentile values in the dose table are normalized for 1 Gy, the test statistic obtained as 0.467, and the H0 hypothesis is rejected at the α=0.975 Statistically, we measured the significant differences between proton and photon dose values for tumors and other organs by Geant4 simulations.
References
- [1] Yeşil S., The Dosimetric Comparison of the Tomotherapy Helical and Tomotherapy Direct Treatment Techniques in the Radiotherapy of Bilateral Breast Cancer, M.Sc., Istanbul Aydin University, Undergraduate Education Institute, (2019).
- [2] Kumaş A., Radiation Physics and Medical Applications, 2nd ed. Ankara, (2006) 128-135.
- [3] Martin J. E., Physics for Radiation Protection, 2nd ed.Berlin, (2011) 251-330.
- [4] Karadeniz Yildirim A., Determination of Internal Dosimetry in Yttrium-90 Microsphere Treatment by Monte Carlo Method, Ph.D., Istanbul University, Institute of Science and Technology, (2019).
- [5] Krane K.S., Nuclear Physics 1, 1st ed, United States of America, (2001) 192-201.
- [6] Armutlu B., Proton Therapy with Gate Simulation in the Treatment of Non-Small Cell Lung Cancer, M.Sc., Istanbul Aydin University, Undergraduate Education Institute, (2020).
- [7] Panagiotis P., Dosimetry Applications in GATE Monte Carlo Toolkit, Physica Medica, 41 (2017) 136-140.
- [8] Shdeed T. A., Nahili M., Issa N. A., Bitar A., Study of absorbed dose in important organs during helical CT chest scan using MCNP code and MIRD phantom, The Egyptian Journal Of Radiology And Nuclear Medicine, 47(4) (2016) 1649-1663.
- [9] Maroufkhani F., Abtahi S.M.M., Kakavand T., Assessment of secondary particles in breast proton therapy by Monte Carlo simulation code using MCNPX, International Journal of Radiation Research, 19(1) (2020) 23-29.
- [10] Lilie L. L., Sabina V., Andreea D., Daniele Ravanelli K. S., Sonny B., Zelig T., Stefan B. & Gary F., Proton beam versus photon beam dose to the heart and left anterior descending artery for left-sided breast cancer, Acta Oncologica, 54(7) (2015) 1032-1039.
- [11] Raptis A., Jakab Ö., Oscar A., Anno M.F., Iuliana T.D., Alexandru D., Cancer risk after breast proton therapy considering physiological and radiobiological uncertainties, Physica Medica, 76 (2020) 1-6.
- [12] Mehrdad B., Dragana K., Dragoslav N., Kwan Y., A comparative study on dispersed doses during photon and proton radiation therapy in pediatric applications, Plos One, 16(3) (2021) 1-20.
Year 2023,
Volume: 44 Issue: 3, 590 - 594, 29.09.2023
Abstract
References
- [1] Yeşil S., The Dosimetric Comparison of the Tomotherapy Helical and Tomotherapy Direct Treatment Techniques in the Radiotherapy of Bilateral Breast Cancer, M.Sc., Istanbul Aydin University, Undergraduate Education Institute, (2019).
- [2] Kumaş A., Radiation Physics and Medical Applications, 2nd ed. Ankara, (2006) 128-135.
- [3] Martin J. E., Physics for Radiation Protection, 2nd ed.Berlin, (2011) 251-330.
- [4] Karadeniz Yildirim A., Determination of Internal Dosimetry in Yttrium-90 Microsphere Treatment by Monte Carlo Method, Ph.D., Istanbul University, Institute of Science and Technology, (2019).
- [5] Krane K.S., Nuclear Physics 1, 1st ed, United States of America, (2001) 192-201.
- [6] Armutlu B., Proton Therapy with Gate Simulation in the Treatment of Non-Small Cell Lung Cancer, M.Sc., Istanbul Aydin University, Undergraduate Education Institute, (2020).
- [7] Panagiotis P., Dosimetry Applications in GATE Monte Carlo Toolkit, Physica Medica, 41 (2017) 136-140.
- [8] Shdeed T. A., Nahili M., Issa N. A., Bitar A., Study of absorbed dose in important organs during helical CT chest scan using MCNP code and MIRD phantom, The Egyptian Journal Of Radiology And Nuclear Medicine, 47(4) (2016) 1649-1663.
- [9] Maroufkhani F., Abtahi S.M.M., Kakavand T., Assessment of secondary particles in breast proton therapy by Monte Carlo simulation code using MCNPX, International Journal of Radiation Research, 19(1) (2020) 23-29.
- [10] Lilie L. L., Sabina V., Andreea D., Daniele Ravanelli K. S., Sonny B., Zelig T., Stefan B. & Gary F., Proton beam versus photon beam dose to the heart and left anterior descending artery for left-sided breast cancer, Acta Oncologica, 54(7) (2015) 1032-1039.
- [11] Raptis A., Jakab Ö., Oscar A., Anno M.F., Iuliana T.D., Alexandru D., Cancer risk after breast proton therapy considering physiological and radiobiological uncertainties, Physica Medica, 76 (2020) 1-6.
- [12] Mehrdad B., Dragana K., Dragoslav N., Kwan Y., A comparative study on dispersed doses during photon and proton radiation therapy in pediatric applications, Plos One, 16(3) (2021) 1-20.
There are 12 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Classical Physics (Other) |
| Journal Section | Natural Sciences |
| Authors | |
| Publication Date | September 29, 2023 |
| Submission Date | January 21, 2022 |
| Acceptance Date | July 31, 2023 |
| Published in Issue | Year 2023Volume: 44 Issue: 3 |
