Research Article
Year 2019,
Volume: 40 Issue: 2, 347 - 354, 30.06.2019
Abstract
SPECT çalışmalarının simülasyonları,
gelişen bilgisayar teknikleriyle birlikte tıbbi görüntülemede daha doğru
sonuçların elde edilebileceği gerçeğine dikkat çekmektedir. Sonuç olarak, canlı
dokulara zarar vermeden yüksek düzeyde istatistik elde etmek için gerçek
olaylara uygulanmadan önce tıbbi simülasyonların yardımıyla yeni fikirler veya
iyileştirmeler görselleştirilebilir. Bu çalışmada, GEANT4 simülasyonları
çerçevesinde geliştirilmiş GATE (a simulation toolkit for PET & SPECT)
yazılımının yetenekleri ile aktivite azalmaları, yer değiştirmeler ve dokuların
üst üste gelmeleri gibi etkilerin uygulamaları üzerine yoğunlaştık. Enerji
histogramları ve doz hesaplamaları, öntanımlı dokular kullanılarak ve ROOT
analiz yazılımı kullanılarak sanal verilerin analiz edilmesiyle elde edildi.
Sonuçlar, SPECT görüntülerde ve bunların spesifik parametrelere bağımlılıklarında
önemli bir bozulmaya neden olabilecek etkilerin büyüklüğünü göstermektedir.
References
- Buck K. A., Nekolla S., Ziegler S., Beer A., Krause A. J., Herrmann K., Scheidhauer K., Wester H., Rummeny E. J., Schwaiger M., Drzezga A., SPECT/CT , J. Nucl. Med., 49 (8) (2008), 1305-1319.
- Bybel B., Brunken R. C., DiFilippo F. P., Neumann D. R., Wu G., Cerqueira M. D., SPECT/CT Imaging: Clinical Utility of an Emerging Technology, Radiographics, 28(4) (2008), 1097-113.
- Madsen, M.T., Recent advances in SPECT imaging., J Nucl. Med., 48(4)(2007), 661–673.
- Groch, M.W., Erwin, W. D., SPECT in the year 2000: Basic Principles, J. Nucl. Med. Technol., 28 (4) (200), 233-44.
- Habib, Z., Hasegawa, B., Determination of the Attenuation Map in Emission Tomography, J. Nucl. Med., 44 (2) (2003), 291-315.
- Khalil M. M., Tremoleda J. L., Tamer B. Bayomy, and W. Gsell, Molecular SPECT Imaging: An Overview, International Journal of Molecular Imaging, 796025 (2011), 1-15
- Müller J., Putora P. M., Schneider T., Zeisel C., Brutsche M., Baty F., Markus A., Kick J., Handheld single photon emission computed tomography (handheld SPECT) navigated video-assisted thoracoscopic surgery of computer tomography-guided radioactively marked pulmonary lesions, Interactive CardioVascular and Thoracic Surgery, 23- 3, (2016), 345–350.
- Patton, J.A., Turkington T.G., SPECT/CT physical principles and attenuation correction., J. Nucl Med Technol., 36(1) (2008), 1-10.
- Keenan, M. A., Stabin M. G., Segars W. P., Fernald M. J., RADAR Realistic Animal Model Series for Dose Assessment, J. Nucl. Med., 51(3) (2010), 471-6.
- Jan, S., et. al., GATE - Geant4 Application for Tomographic Emission: a simulation toolkit for PET and SPECT, Phys Med Biol. , 49 (19) (2004), 4543–4561.
- Arce P., Mendes P. R., Lagares J. I., GAMOS: a GEANT4-based Easy and Flexible Framework for Nuclear Geant4 Simulations, IEEE Proc. Nuc. Sci. Symp. Conf. Rec., 1 (2008), 3162 - 3168.
- CERN-MEDICIS Collaboration, CERN-MEDICIS (Medical Isotopes Collected from ISOLDE): A New Facility, Appl. Sci., 4(2) (2014), 265-281.
- http://www.opengatecollaboration.org/sites/default/files/GATE-UsersGuideV8.0.pdf
Year 2019,
Volume: 40 Issue: 2, 347 - 354, 30.06.2019
Abstract
Simulations of SPECT studies have been taken attention with
the fact that more accurate results can be constructed in medical imaging with developing
computing techniques. As a result, one can visualize new ideas or improvements
with the help of medical simulations before applying on real incidents for
clinical purposes acquiring high level of statistics without harming live
tissues. In this study, we focused on the capability of GATE (a simulation
toolkit for PET & SPECT) that is developed under GEANT4 simulation
framework and applications on the effects such as activity degradations,
displacements and overlapping of the tissues. Energy histograms and dose
calculations are obtained by using built-in tissues and analyzing virtual data
using ROOT analysis software. Results show the magnitudes of effects that may
have a significant disturbance on SPECT images and their dependence on spesific
parameters.
the fact that more accurate results can be constructed in medical imaging with developing
computing techniques. As a result, one can visualize new ideas or improvements
with the help of medical simulations before applying on real incidents for
clinical purposes acquiring high level of statistics without harming live
tissues. In this study, we focused on the capability of GATE (a simulation
toolkit for PET & SPECT) that is developed under GEANT4 simulation
framework and applications on the effects such as activity degradations,
displacements and overlapping of the tissues. Energy histograms and dose
calculations are obtained by using built-in tissues and analyzing virtual data
using ROOT analysis software. Results show the magnitudes of effects that may
have a significant disturbance on SPECT images and their dependence on spesific
parameters.
References
- Buck K. A., Nekolla S., Ziegler S., Beer A., Krause A. J., Herrmann K., Scheidhauer K., Wester H., Rummeny E. J., Schwaiger M., Drzezga A., SPECT/CT , J. Nucl. Med., 49 (8) (2008), 1305-1319.
- Bybel B., Brunken R. C., DiFilippo F. P., Neumann D. R., Wu G., Cerqueira M. D., SPECT/CT Imaging: Clinical Utility of an Emerging Technology, Radiographics, 28(4) (2008), 1097-113.
- Madsen, M.T., Recent advances in SPECT imaging., J Nucl. Med., 48(4)(2007), 661–673.
- Groch, M.W., Erwin, W. D., SPECT in the year 2000: Basic Principles, J. Nucl. Med. Technol., 28 (4) (200), 233-44.
- Habib, Z., Hasegawa, B., Determination of the Attenuation Map in Emission Tomography, J. Nucl. Med., 44 (2) (2003), 291-315.
- Khalil M. M., Tremoleda J. L., Tamer B. Bayomy, and W. Gsell, Molecular SPECT Imaging: An Overview, International Journal of Molecular Imaging, 796025 (2011), 1-15
- Müller J., Putora P. M., Schneider T., Zeisel C., Brutsche M., Baty F., Markus A., Kick J., Handheld single photon emission computed tomography (handheld SPECT) navigated video-assisted thoracoscopic surgery of computer tomography-guided radioactively marked pulmonary lesions, Interactive CardioVascular and Thoracic Surgery, 23- 3, (2016), 345–350.
- Patton, J.A., Turkington T.G., SPECT/CT physical principles and attenuation correction., J. Nucl Med Technol., 36(1) (2008), 1-10.
- Keenan, M. A., Stabin M. G., Segars W. P., Fernald M. J., RADAR Realistic Animal Model Series for Dose Assessment, J. Nucl. Med., 51(3) (2010), 471-6.
- Jan, S., et. al., GATE - Geant4 Application for Tomographic Emission: a simulation toolkit for PET and SPECT, Phys Med Biol. , 49 (19) (2004), 4543–4561.
- Arce P., Mendes P. R., Lagares J. I., GAMOS: a GEANT4-based Easy and Flexible Framework for Nuclear Geant4 Simulations, IEEE Proc. Nuc. Sci. Symp. Conf. Rec., 1 (2008), 3162 - 3168.
- CERN-MEDICIS Collaboration, CERN-MEDICIS (Medical Isotopes Collected from ISOLDE): A New Facility, Appl. Sci., 4(2) (2014), 265-281.
- http://www.opengatecollaboration.org/sites/default/files/GATE-UsersGuideV8.0.pdf
There are 13 citations in total.
Details
| Primary Language | English |
|---|---|
| Journal Section | Natural Sciences |
| Authors | |
| Publication Date | June 30, 2019 |
| Submission Date | March 1, 2019 |
| Acceptance Date | March 27, 2019 |
| Published in Issue | Year 2019Volume: 40 Issue: 2 |