Abstract
Sepsis is a life-threatening syndrome that may lead to multiple organ dysfunction with high mortality. A deformation or puncture in the intestinal barrier plays an important role in sepsis-induced multiple organ failure. The protective effects of 6-Shogaol (6-SHO) on renal injury caused by cecal ligation and puncture (CLP) was investigated. Experimental animals were divided into 4 groups and planned as follows; sham, CLP, CLP+DMSO, and CLP+6-SHO. In CLP + 6-SHO group, 20 mg/kg 6-SHO was administered intraperitoneally before the CLP model. The levels of antioxidant molecules (total antioxidant status (TAS) and superoxide dismutase (SOD)), oxidant molecules (total oxidant status (TOS), malondialdehyde (MDA) and myeloperoxidase (MPO)) and proinflammatory cytokines (tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β)) were measured by homogenizing in collected kidney tissues. Statistical analyzes were performed via ANOVA. In CLP groups, antioxidant molecule levels decreased while oxidant molecule values elevated. Similarly, proinflammatory cytokine levels were found high in CLP groups. In CLP+6-SHO group, oxidant molecules, MPO, and proinflammatory cytokine levels diminished, and antioxidant molecules increased. 6-SHO application has been shown to be effective against oxidative renal injury caused by the CLP-induced polymicrobial sepsis model.
Thanks
We would like to thanks all participants and also Kardelen Erdoğan and Yaylagülü Yaman, undergraduates of Atatürk University Nursing Faculty.