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Düşük-Orta İrtifaya Aklimatize Sporcularda Egzersiz Öncesi ve Sonrası HIF-1⍺ ve EPO Düzeylerinin Karşılaştırılması

Year 2023, Volume: 6 Issue: 1-Cumhuriyet'in 100. Yılı Özel Sayısı, 958 - 971, 29.10.2023

Mehmet Kuzucu Sibel Tetik Dündar Murat Özdal

https://doi.org/10.38021/asbid.1373832

Abstract

Bu çalışma, düşük-orta irtifaya uyum sağlamış, iyi antrenmanlı erkek kayakçılarda akut egzersizin HIF-1⍺ ve EPO serum düzeylerine etkisini incelemek amacıyla yapıldı. Çalışma, yaş ortalaması 20.33±1.91yıl, boy ortalaması 170.93±10.62cm, vücut kütle ortalaması 62.80±11.00kg olan 15 erkek kayakçı ile yapıldı. Katılımcıların, VO2max için Bruce treadmill testi yapıldı. Seçilmiş kan hücreleri, HIF-1α ve EPO düzeylerinin belirlenmesi; 1000m rakım düzeyinde katılımcılardan kan alımı, aynı gün içerisinde 2000m rakımlı kayak merkezinde egzersiz testi ve 2 saat sonrasında tekrar kan alımı, ertesi sabah yine kan alımı şeklinde üç tekrarlı olarak yapıldı. Normal antrenman döngülerine devam eden kayakçılar, tek tekrarlı egzersiz protokolüne tabi tutularak, öncesi-sonrası yapılan kan testleriyle, ilgili markerlerin düzeyi belirlendi. Sonuç olarak, seçilmiş kan parametrelerinde en yüksek düzeye son testte (24 saat sonra) ulaşıldı (WBC hariç). WBC, RBC, HGB, HCT parametrelerinde testler arası farkın anlamlı olduğu (p<0.05) görüldü (PLT hariç). HIF-1α düzeyinde testler arasındaki farkın anlamlı olmadığı (p>0.05) görülürken, EPO düzeyinde anlamlı olduğu (p<0.05) belirlendi. Bu tip çalışmalarda, sedanter-sporcu karşılaştırması, kronik egzersiz testlerinin yapılması ve zamansal takibin daha geniş saatlere/günlere yayılmasının daha nitelikli sonuçlarla literatüre katkı sağlayacağı düşünülmektedir.

Keywords

Hif-1 Alfa Epo İrtifa Hipoksi Aerobik Egzersiz

References

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Comparison of HIF-1⍺ and EPO Levels Before and After Exercise in Athletes Acclimatized to Low-Middle Altitude

Year 2023, Volume: 6 Issue: 1-Cumhuriyet'in 100. Yılı Özel Sayısı, 958 - 971, 29.10.2023

Mehmet Kuzucu Sibel Tetik Dündar Murat Özdal

https://doi.org/10.38021/asbid.1373832

Abstract

This study was conducted to examine the effect of acute exercise on HIF-1⍺ and EPO serum levels in well-trained male skiers adapted to low-medium altitude. The study was conducted with 15 male skiers with an average age of 20.33±1.91 years, average height of 170.93±10.62cm, and average body mass of 62.80±11.00kg. Bruce Treadmill test was performed to determine the participants' maximum oxygen consumption and to interpret their aerobic power levels. Determination of levels of selected blood cells, HIF-1α and EPO; Blood was taken from the participants at an altitude of 1000m, an exercise test was performed at the ski resort at an altitude of 2000m on the same day, blood was taken again 2 hours later, and blood was taken again the next morning, three times. Skiers who continued their normal training cycles were subjected to a single-repetition exercise protocol and the levels of relevant markers were determined with before and after blood tests. As a result, the highest level in selected blood parameters was reached at the last test (after 24 hours) (except WBC). It was observed that the difference between the tests was significant (p<0.05) in WBC, RBC, HGB, HCT parameters (except PLT). While the difference between the tests at the HIF-1α level was not significant (p>0.05), it was determined to be significant at the EPO level (p<0.05). In such studies, it is thought that sedentary-athlete comparison, chronic exercise tests and temporal follow-up spread over wider hours/days will contribute to the literature with more qualified results.

Keywords

Hif-1 Alpha Epo Altitude Hypoxia Aerobic Exercise

References

  • Amaro-Gahete F.J., de-la-O, A., Jurado-Fasoli, L., Gutiérrez, Á., Ruiz, J.R. ve Castillo, M.J. (2019). Association of physical activity and fitness with S-Klotho plasma levels in middle-aged sedentary adults. the FIT-AGEING study. Maturitas, 123,25-31. DOI: 10.1016/j.maturitas.2019.02.001
  • Baygutalp, F., Buzdağlı, Y., Ozan, M., Koz, M., Kılıç Baygutalp, N. ve Atasever, G. (2021). Impacts of different intensities of exercise on inflammation and hypoxia markers in low altitude, BMC Sports Sci Med Rehabil. Nov 22;13(1):145. DOI: 10.1186/s13102-021-00375-0
  • Bruce, R.A., Kusumi, F. ve Hosmer, D. (1973): Maximal oxygen intake and nomographic assessment of functional aerobic impairment in cardiovascular disease. Am Heart J 85:546-551. DOI: 10.1016/0002-8703(73)90502-4
  • Budak, C., Uçan, İ., Dündar, S.T. ve Mertoğlu, C. (2023). Sstudy on vitamin d, cortisol and testosterone values in male skiers by seasonal cycles, The Online Journal of Recreation and Sports (TOJRAS), 12(3), 270-278.DOI: 10.22282/tojras.1275508
  • Chapman, R.F., Stray-Gundersen, J. ve Levine, B.D. (1998). Individual variation in response to altitude training. Journal of Applied Physiology 85, 1448-1456. DOI: 10.1152/jappl.1998.85.4.1448
  • Chavez, J.C., Baranova, O., Lin, J. ve Pichiule, P. (2006). The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes. J Neurosci, 26(37):9471-9481. DOI: 10.1523/JNEUROSCI.2838-06.2006
  • Chen, C.D., Podvin, S., Gillespie, E., Leeman, S.E. ve Abraham, C.R. (2007). Insulin stimulates the cleavage and release of the extra-cellular domain of Klotho by adaM10 and adaM17. procNatl Acad Sci USA,104:19796-801. DOI: 10.1073/pnas.0709805104
  • Czuba, M., Fidos-Czuba, O., Płoszczyca, K., Zając, A. ve Langfort, J. (2018). Comparison of the effect of intermittent hypoxic training vs. the live high, train low strategy on aerobic capacity and sports performance in cyclists in normoxia. Biol Sport. 35(1): 39–48. DOI: 10.5114/biolsport.2018.70750
  • Czuba, M., Maszczyk, A., Gerasimuk, D., Roczniok, R., Fidos-Czuba, O., Zając, A., Gołaś, A., Mostowik, A. ve Langfort, J. (2014). The effects of hypobaric hypoxia on erythropoiesis, maximal oxygen uptake and energy cost of exercise under normoxia in elite biathletes. J Sports Sci Med. Dec 1;13(4): 912-20.
  • Eltzschig, H.K. ve Carmeliet, P. (2011). Hypoxia and inflammation. N. Engl. J. Med. 364, 656–665. DOI: 10.1056/NEJMra0910283
  • Ericsson, K.A., Nandagopal, K. ve Roring, R.W. (2009). Toward a science of exceptional achievement: attaining superior performance through deliberate practice. Ann N Y Acad. Sci, 1172, 199–217. DOI: 10.1196/annals.1393.001
  • Foley, R.N. (2008). Erythropoietin: physiology and molecular mechanisms, Heart Fail Rev 13:405–414. DOI: 10.1007/s10741-008-9083-0
  • Foster, C., Jackson, A. S., Pollock, M. L., Taylor, M. M., Hare, J., Sennett, S. M., Rod, J. L., Sarwar, M. ve Schmidt, D. H. (1984) Generalized Equations For Predicting Functional Capacity From Treadmill Performance. American Heart Journal 107: 1229: 1234. DOI: 10.1016/0002-8703(84)90282-5
  • Girginer, F., Büyükyazı, G., Ulman, C., Doğru, Y., Taneli, F., Yıldız, R., Taş, M. ve Keskinoğlu, P. (2019). Comparison of Some Plasma InflammationMarkers in Elite Master Athletes, Recreational Athletes andSedentary Males. Türkiye Klinikleri J Med Sci, 39(2), (s. 202-11). DOI: 10.5336/medsci.2018-63235
  • Gruber, M., Hu, C.J., Johnson, R.S., Brown, E.J., Keith, B. ve Simon, M.C. (2007). Acute postnatal ablation of Hif-2alpha results in anemia. Proc Natl Acad Sci USA, 104(7):2301-2306. DOI: 10.1073/pnas.0608382104
  • Haase, V.H. (2013). Regulation of Erythropoiesis by Hypoxia-Inducible Factors. Blood Rev. 27, 41–53. DOI: 10.1016/j.blre.2012.12.003
  • Hawley, J.A., Lundby, C., Cotter, J.D. ve Burke, L.M. (2018). Maximizing Cellular Adaptation to Endurance Exercise in Skeletal Muscle, Cell Metabolism 27(5):962-976. DOI: 10.1016/j.cmet.2018.04.014
  • Hirota, K. ve Semenza, GL. (2006). Regulation of angiogenesis by hypoxia-inducible factor 1. Crit Rev Oncol Hematol, 59(19):15-26. DOI: 10.1016/j.critrevonc.2005.12.003
  • Hu, C.J., Wang, L.Y., Chodosh, L.A., Keith, B. ve Simon, M.C. (2003). Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol. Cell. Biol. 23, 9361–9374. DOI: 10.1128/MCB.23.24.9361-9374.2003
  • Kalinowski, L., Janaszak-Jasiecka, A., Siekierzycka, A., Bartoszewska, S., Wo´zniak, M., Lejnowski, D., Collawn, J.F. ve Bartoszewska, R. (2016) Posttranscriptional and transcriptional regulation of endothelial nitric-oxide synthase during hypoxia: the role ofmicroRNAs. Cell. Mol. Biol. Lett. 21, 16. DOI: 10.1186/s11658-016-0017-x
  • Keith, B., Johnson, R.S. ve Simon, M.C. (2011). HIF1a andHIF2a: sibling rivalry in hypoxic tumour growth and progression. Nat. Rev.Cancer, 12, 9–22. DOI: 10.1038/nrc3183
  • Koh, M.Y. ve Powis, G. (2012). Passing the button: the HIF swich. Trends in Biochemical Sciences; 37(9):364-372. DOI: 10.1016/j.tibs.2012.06.004
  • Li, J., Li, Y., Atakan, M.M., Kuang, J., Hu, Y., Bishop, D.J. ve Yan, X. (2020). The Molecular Adaptive Responses of Skeletal Muscle to High-Intensity Exercise/Training and Hypoxia, Antioxidants, 9(8):656. DOI: 10.3390/antiox9080656
  • McArdle, A., Pattwell, D., Vasilaki ,A., Griffiths, R.D. ve Jackson M.J. (2001). Contractile activity-induced oxidative stress: cellu-lar origin and adaptive responses. Am J Physiol Cell Physiol, 280:C621-7. DOI: 10.1152/ajpcell.2001.280.3.C621
  • Mostafidi, E., Moeen, A., Nasri, H., Ghorbani, Hagjo. ve A, Ardalan M. (2016). Serum klotho levels in trained athletes. Nephrourol Mon,8:e30245. DOI: 10.5812/numonthly.30245
  • Park, HY., Jung, WS., Kim, SW., Kim, J. ve Lim, K. (2022). Effects of Interval Training Under Hypoxia on Hematological Parameters, Hemodynamic Function, and Endurance Exercise Performance in Amateur Female Runners in Korea, Physiol, May 18; 13: 919008. DOI: 10.3389/fphys.2022.919008
  • Pedersen, L., Pedersen, S.M., Brasen, C.L. ve Rasmussen LM. (2013). Soluble serum Klotho levels in healthy subjects.comparison of two different immunoassays. Clin Biochem, 46:1079-83. DOI: 10.1016/j.clinbiochem.2013.05.046
  • Pramkratok, W., Songsupap, T. ve Yimlamai, T. (2022). Repeated sprint training under hypoxia improves aerobic performance and repeated sprint ability by enhancing muscle deoxygenation and markers of angiogenesis in rugby sevens, Eur J Appl Physiol, Mar;122(3):611-622. DOI: 10.1007/s00421-021-04861-8
  • Rankin, E.B., Biju, M.P., Liu, Q., Unger, T.L., Rha, J., Johnson, R.S., Simon, M.C., Keith, B ve Haase, V.H.(2007). Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest, 117(4):1068-1077. DOI: 10.1172/JCI30117
  • Saghiv MS, Ben-Sira D, Goldhammer E ve Sagiv M. (2019). Are s-klotho’s maximal concentrations dependent on exercise in-tensity and time in young adult males? J cardiol cardiovasc Med, 4:6-11. DOI: 10.29328/journal.jccm.1001033
  • Semenza, G.L. (1999). Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu. Rev. Cell Dev. Biol, 15, 551–578. DOI: 10.1146/annurev.cellbio.15.1.551
  • Semenza, G.L. (2001) HIF-1, O (2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell 107:1–3. DOI: 10.1016/s0092-8674(01)00518-9
  • Semenza, G.L., Nejfelt, M.K., Chi, S.M. ve Antonarakis, S.E. (1991). Hypoxia-inducible nuclear factors bind to an enhancer element located 3’ to the human erythropoietin gene. Proc. Natl. Acad. Sci. USA 88, 5680–5684. DOI: 10.1073/pnas.88.13.5680
  • Teti̇k Dündar, S., Akcan, İ.O, ve Ağgön, E. (2023a). Investigation of some physical parameters and aerobic–anaerobic power outcomes in mountain skiers. Research in Sport Education and Sciences, 25(1), 1-6.
  • Tetik Dündar, S., Kuzucu, M. ve Varol, S.R. (2023b). Effect of the aerobic power test performed at low-medium altitude on the myostatin, pgc-1 alpha and klotho levels. Gazz Med Ital-Arch Sci Med, 182:342-51.
  • Tomc, J. ve Debeljak, N. (2021). Molecular Insights into the Oxygen-Sensing Pathway and Erythropoietin Expression Regulation in Erythropoiesis, Int. J. Mol. Sci. 22, 7074. DOI: 10.3390/ijms22137074
  • Tucker, R. ve Collins, M. (2012). What makes champions? A review of the relative contribution of genes and training to sporting success. Br. J. Sports Med. 46, 555–561. DOI: 10.1136/bjsports-2011-090548
  • Van Thienen, R., Masschelein, E., D’Hulst, G., Thomis, M. ve Hespel, P. (2016). Twin Resemblance in Muscle HIF-1alpha Responses to Hypoxia and Exercise. Front. Physiol. 7, 676. DOI: 10.3389/fphys.2016.00676
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There are 43 citations in total.

Details

Primary Language Turkish
Subjects Sports Nutrition
Journal Section Arşiv
Authors

Mehmet Kuzucu 0000-0002-7786-7687

Sibel Tetik Dündar 0000-0001-6813-0969

Murat Özdal 0009-0002-3746-1436

Early Pub Date October 25, 2023
Publication Date October 29, 2023
Submission Date October 10, 2023
Acceptance Date October 20, 2023
Published in Issue Year 2023 Volume: 6 Issue: 1-Cumhuriyet'in 100. Yılı Özel Sayısı

Cite

APA Kuzucu, M., Tetik Dündar, S., & Özdal, M. (2023). Düşük-Orta İrtifaya Aklimatize Sporcularda Egzersiz Öncesi ve Sonrası HIF-1⍺ ve EPO Düzeylerinin Karşılaştırılması. Akdeniz Spor Bilimleri Dergisi, 6(1-Cumhuriyet’in 100. Yılı Özel Sayısı), 958-971. https://doi.org/10.38021/asbid.1373832
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